List of investigational anxiolytics
This is a list of investigational anxiolytics, or anxiolytics that are currently under development for clinical use but are not yet approved. Chemical/generic names are listed first, with developmental code names, synonyms, and brand names in parentheses.
Generalized anxiety disorder
- Agomelatine (AGO-178; Valdoxan) – melatonin MT1 and MT2 receptor agonist, 5-HT2C receptor antagonist[1]
- Riluzole sublingual (BHV-0223) – undefined mechanism of action[2]
- TGFK08AA – 5-HT1A receptor modulator[3]
- TGW00AA (FKW00GA) – 5-HT1A receptor agonist, 5-HT2A receptor antagonist [4]
- Vilazodone (EMD-68843, SB-659746A; Viibryd) – 5-HT1A receptor partial agonist and serotonin reuptake inhibitor[5]
- Vortioxetine (LU-AA21004; Brintellix, Trintellix) – serotonin reuptake inhibitor, 5-HT1A receptor agonist, and 5-HT3 and 5-HT7 receptor antagonist [6]
Panic disorder
- NBTX-001 (Xenon) – NMDA receptor antagonist [7]
Post-traumatic stress disorder
- 7-Oxoprasterone (7-keto-DHEA; HBL-9001) – "immunomodulator" / undefined mechanism of action [8]
- Acamprosate (SNC-102) – undefined mechanism of action [9]
- BNC-210 (IW-2143) – "GABA modulator"[1] / undefined mechanism of action[2][10]
- Brexpiprazole (Lu AF41156, OPC-34712; Rexulti) – atypical antipsychotic / 5-HT1A, D2 and D3 receptor partial agonist and 5-HT2A, 5-HT2B, 5-HT7, α1-adrenergic, α2-adrenergic, and H1 receptor antagonist [11]
- Cyclobenzaprine (TNX-102) – undefined mechanism of action [12]
- Iloperidone (HP-873, ILO-522; Fanapt, Fiapta, Zomaril) – atypical antipsychotic / 5-HT2A, 5-HT6, 5-HT7, D2, D3, D4, and α1-adrenergic receptor antagonist [13]
- MDMA (Midomafetamine, 3,4-methylenedioxymethamphetamine, "ecstasy") – serotonin–norepinephrine–dopamine releasing agent and 5-HT1 and 5-HT2 receptor agonist – specifically under development as an aid to psychotherapy for post-traumatic stress disorder[3][4]
- NBTX-001 (Xenon) – NMDA receptor antagonist [14]
- Pomaglumetad methionil (DB-103, LY-2140023) – mGluR2 and mGluR3 agonist [15]
- Tianeptine oxalate (TNX-601) – atypical μ-opioid receptor agonist [16]
- Verucerfont (GSK-561679, NBI-77860) – CRF1 receptor antagonist [17]
Social anxiety disorder
- 4-Androstadienol (Aloradine; PH94B) – vomeropherine / neurosteroid[18]
- Fluvoxamine extended release - Serotonin uptake inhibitors. [5]
- Riluzole sublingual (BHV-0223) – "glutamate modulator" / undefined mechanism of action [19]
- TGW00AA (FKW00GA) – 5-HT1A receptor agonist, 5-HT2A receptor antagonist [20]
- Verucerfont (GSK-561679, NBI-77860) – CRF1 receptor antagonist [21]
- Vilazodone (EMD-68843, SB-659746A; Viibryd) – 5-HT1A receptor partial agonist and serotonin reuptake inhibitor [22]
- Vortioxetine (LU-AA21004; Brintellix, Trintellix) – serotonin reuptake inhibitor, 5-HT1A receptor agonist, and 5-HT3 and 5-HT7receptor antagonist [6]
- JNJ-42165279 - FAAH inhibitor[7][8]
unspecified
- AVN-101 – 5-HT6 receptor antagonist [23]
- BNC-210 (IW-2143) – "GABA modulator"[1] / undefined mechanism of action[2][24]
- JNJ-42165279 – FAAH inhibitor[25]
- MP-20X – CB1 and 5-HT1A receptor modulator [26]
- SRX-246 – vasopressin V1A receptor antagonist [27]
See also
References
- ^ a b Garakani, Amir; Murrough, James W.; Iosifescu, Dan V. (2014). "Advances in Psychopharmacology for Anxiety Disorders". FOCUS. 12 (2): 152–162. doi:10.1176/appi.focus.12.2.152. ISSN 1541-4094.
- ^ a b Doggrell, S. A. (2007). Novel drugs and products in neuroscience. Drugs of the Future, 32(11), 1007-1017. https://journals.prous.com/journals/servlet/xmlxsl/pk_journals.xml_summary_pr?p_JournalId=2&p_RefId=3853&p_IsPs=Y
- ^ Sessa B (2017). "MDMA and PTSD treatment: "PTSD: From novel pathophysiology to innovative therapeutics"". Neurosci. Lett. 649: 176–180. doi:10.1016/j.neulet.2016.07.004. PMID 27394687.
- ^ Philipps, Dave (29 November 2016). "F.D.A. Agrees to New Trials for Ecstasy as Relief for PTSD Patients". Retrieved 1 June 2017.
- ^ "Fluvoxamine extended release - Beijing CoSci Med Tech - AdisInsight". adisinsight.springer.com. Retrieved 2019-08-06.
- ^ "Vortioxetine - Lundbeck A/S - AdisInsight". adisinsight.springer.com. Retrieved 2019-03-02.
- ^ "JNJ 42165279 - AdisInsight". adisinsight.springer.com. Retrieved 2019-03-02.
- ^ "A Safety and Efficacy Study of JNJ-42165279 in Participants With Social Anxiety Disorder | Clinical Research Trial Listing ( Claustrophobia ) ( NCT02432703 )". www.centerwatch.com. Retrieved 2019-03-02.