C8 complex

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High Resolution Crystal Structure of Human Complement Component 8[1]
complement component 8, alpha polypeptide
Identifiers
SymbolC8A
NCBI gene731
HGNC1352
OMIM120950
RefSeqNM_000562
UniProtP07357
Other data
LocusChr. 1 p36.2-22.1
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StructuresSwiss-model
DomainsInterPro
complement component 8, beta polypeptide
Identifiers
SymbolC8B
NCBI gene732
HGNC1353
OMIM1209660
RefSeqNM_000066
UniProtP073o58
Other data
LocusChr. 1 p36.2-22.1
Search for
StructuresSwiss-model
DomainsInterPro
complement component 8, gamma polypeptide
Identifiers
SymbolC8G
NCBI gene733
HGNC1354
OMIM120930
RefSeqNM_000606
UniProtP07360
Other data
LocusChr. 9 q34.3
Search for
StructuresSwiss-model
DomainsInterPro
Membrane attack complex. Some labels are in Polish.

Structure

C8 is a heterotrimer; it consists of three different subunits. These are called C8 alpha, beta and gamma chains, encoded by the genes C8A, C8B and C8G respectively.

References

  1. ^ PDB: 3OJY​; Lovelace LL, Cooper CL, Sodetz JM, Lebioda L (May 2011). "Structure of human C8 protein provides mechanistic insight into membrane pore formation by complement". The Journal of Biological Chemistry. 286 (20): 17585–92. doi:10.1074/jbc.M111.219766. PMC 3093833. PMID 21454577.{{cite journal}}: CS1 maint: unflagged free DOI (link)

External links