C5a receptor

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Complement component 5a receptor 1
Symbols C5AR1 ; C5A; C5AR; C5R1; CD88
External IDs OMIM113995 MGI88232 HomoloGene20413 IUPHAR: 32 ChEMBL: 2373 GeneCards: C5AR1 Gene
RNA expression pattern
PBB GE C5AR1 220088 at tn.png
More reference expression data
Species Human Mouse
Entrez 728 12273
Ensembl ENSG00000197405 ENSMUSG00000049130
UniProt P21730 P30993
RefSeq (mRNA) NM_001736 NM_001173550
RefSeq (protein) NP_001727 NP_001167021
Location (UCSC) Chr 19:
47.29 – 47.32 Mb
Chr 7:
16.25 – 16.26 Mb
PubMed search [1] [2]

The C5a receptor also known as complement component 5a receptor 1 (C5AR1) or CD88 (Cluster of Differentiation 88) is a G protein-coupled receptor for C5a. It functions as a complement receptor.[1]

C5a receptor structure and its residues possessing role in ligand binding or signaling.


The C5a receptor is expressed on:[2]

See also[edit]


  1. ^ Gerard C, Gerard NP (1994). "C5A anaphylatoxin and its seven transmembrane-segment receptor". Annu. Rev. Immunol. 12: 775–808. doi:10.1146/annurev.iy.12.040194.004015. PMID 8011297. 
  2. ^ Klos A, Wende E, Wareham KJ, Monk PN. (2013). "International Union of Pharmacology. LXXXVII. Complement peptide C5a, C4a, and C3a receptors". Pharmacol. Rev. 65 (1): 500–43. doi:10.1124/pr.111.005223. PMID 23383423. 

Further reading[edit]

  • Sengeløv H (1996). "Complement receptors in neutrophils.". Crit. Rev. Immunol. 15 (2): 107–31. doi:10.1615/critrevimmunol.v15.i2.10. PMID 8573284. 
  • Beil WJ, Schulz M, Wefelmeyer U (2001). "Mast cell granule composition and tissue location--a close correlation.". Histol. Histopathol. 15 (3): 937–46. PMID 10963136. 
  • Yamamoto T (2007). "Roles of the ribosomal protein S19 dimer and the C5a receptor in pathophysiological functions of phagocytic leukocytes.". Pathol. Int. 57 (1): 1–11. doi:10.1111/j.1440-1827.2007.02049.x. PMID 17199736. 
  • Bao L, Gerard NP, Eddy RL; et al. (1992). "Mapping of genes for the human C5a receptor (C5AR), human FMLP receptor (FPR), and two FMLP receptor homologue orphan receptors (FPRH1, FPRH2) to chromosome 19.". Genomics 13 (2): 437–40. doi:10.1016/0888-7543(92)90265-T. PMID 1612600. 
  • Gerard NP, Gerard C (1991). "The chemotactic receptor for human C5a anaphylatoxin.". Nature 349 (6310): 614–7. doi:10.1038/349614a0. PMID 1847994. 
  • Boulay F, Mery L, Tardif M; et al. (1991). "Expression cloning of a receptor for C5a anaphylatoxin on differentiated HL-60 cells.". Biochemistry 30 (12): 2993–9. doi:10.1021/bi00226a002. PMID 2007135. 
  • Wahl SM, Allen JB, Gartner S; et al. (1989). "HIV-1 and its envelope glycoprotein down-regulate chemotactic ligand receptors and chemotactic function of peripheral blood monocytes.". J. Immunol. 142 (10): 3553–9. PMID 2541200. 
  • Foreman KE, Vaporciyan AA, Bonish BK; et al. (1994). "C5a-induced expression of P-selectin in endothelial cells.". J. Clin. Invest. 94 (3): 1147–55. doi:10.1172/JCI117430. PMC 295185. PMID 7521884. 
  • Giannini E, Brouchon L, Boulay F (1995). "Identification of the major phosphorylation sites in human C5a anaphylatoxin receptor in vivo.". J. Biol. Chem. 270 (32): 19166–72. doi:10.1074/jbc.270.32.19166. PMID 7642584. 
  • Buhl AM, Osawa S, Johnson GL (1995). "Mitogen-activated protein kinase activation requires two signal inputs from the human anaphylatoxin C5a receptor.". J. Biol. Chem. 270 (34): 19828–32. doi:10.1074/jbc.270.34.19828. PMID 7649993. 
  • Wennogle LP, Conder L, Winter C; et al. (1994). "Stabilization of C5a receptor--G-protein interactions through ligand binding.". J. Cell. Biochem. 55 (3): 380–8. doi:10.1002/jcb.240550316. PMID 7962171. 
  • Gerard NP, Bao L, Xiao-Ping H; et al. (1993). "Human chemotaxis receptor genes cluster at 19q13.3-13.4. Characterization of the human C5a receptor gene.". Biochemistry 32 (5): 1243–50. doi:10.1021/bi00056a007. PMID 8383526. 
  • Ames RS, Li Y, Sarau HM; et al. (1996). "Molecular cloning and characterization of the human anaphylatoxin C3a receptor.". J. Biol. Chem. 271 (34): 20231–4. doi:10.1074/jbc.271.34.20231. PMID 8702752. 
  • Werfel T, Zwirner J, Oppermann M; et al. (1996). "CD88 antibodies specifically bind to C5aR on dermal CD117+ and CD14+ cells and react with a desmosomal antigen in human skin.". J. Immunol. 157 (4): 1729–35. PMID 8759762. 
  • Höpken UE, Lu B, Gerard NP, Gerard C (1996). "The C5a chemoattractant receptor mediates mucosal defence to infection.". Nature 383 (6595): 86–9. doi:10.1038/383086a0. PMID 8779720. 
  • Chen Z, Zhang X, Gonnella NC; et al. (1998). "Residues 21-30 within the extracellular N-terminal region of the C5a receptor represent a binding domain for the C5a anaphylatoxin.". J. Biol. Chem. 273 (17): 10411–9. doi:10.1074/jbc.273.17.10411. PMID 9553099. 
  • Floreani AA, Heires AJ, Welniak LA; et al. (1998). "Expression of receptors for C5a anaphylatoxin (CD88) on human bronchial epithelial cells: enhancement of C5a-mediated release of IL-8 upon exposure to cigarette smoke.". J. Immunol. 160 (10): 5073–81. PMID 9590258. 
  • Ottonello L, Corcione A, Tortolina G; et al. (1999). "rC5a directs the in vitro migration of human memory and naive tonsillar B lymphocytes: implications for B cell trafficking in secondary lymphoid tissues.". J. Immunol. 162 (11): 6510–7. PMID 10352266. 
  • Kohleisen B, Shumay E, Sutter G; et al. (2000). "Stable expression of HIV-1 Nef induces changes in growth properties and activation state of human astrocytes.". AIDS 13 (17): 2331–41. doi:10.1097/00002030-199912030-00004. PMID 10597774. 
  • Monk PN, Scola A-M, Madala P, Fairlie DP (2007). "Function, structure and therapeutic potential of complement C5a receptors". British Journal of Pharmacology 152 (4): 429–48. doi:10.1038/sj.bjp.0707332. PMC 2050825. PMID 17603557. 

External links[edit]