C5a receptor

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Complement component 5a receptor 1
Identifiers
Symbols C5AR1 ; C5A; C5AR; C5R1; CD88
External IDs OMIM113995 MGI88232 HomoloGene20413 IUPHAR: 32 ChEMBL: 2373 GeneCards: C5AR1 Gene
RNA expression pattern
PBB GE C5AR1 220088 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 728 12273
Ensembl ENSG00000197405 ENSMUSG00000049130
UniProt P21730 P30993
RefSeq (mRNA) NM_001736 NM_001173550
RefSeq (protein) NP_001727 NP_001167021
Location (UCSC) Chr 19:
47.29 – 47.32 Mb
Chr 7:
16.25 – 16.26 Mb
PubMed search [1] [2]

The C5a receptor also known as complement component 5a receptor 1 (C5AR1) or CD88 (Cluster of Differentiation 88) is a G protein-coupled receptor for C5a. It functions as a complement receptor.[1]

C5a receptor structure and its residues possessing role in ligand binding or signaling.

Cells[edit]

The C5a receptor is expressed on:[2]

See also[edit]

References[edit]

  1. ^ Gerard C, Gerard NP (1994). "C5A anaphylatoxin and its seven transmembrane-segment receptor". Annual Review of Immunology 12: 775–808. doi:10.1146/annurev.iy.12.040194.004015. PMID 8011297. 
  2. ^ Klos A, Wende E, Wareham KJ, Monk PN (Jan 2013). "International Union of Basic and Clinical Pharmacology. [corrected]. LXXXVII. Complement peptide C5a, C4a, and C3a receptors". Pharmacological Reviews 65 (1): 500–43. doi:10.1124/pr.111.005223. PMID 23383423. 

Further reading[edit]

  • Sengeløv H (1996). "Complement receptors in neutrophils". Critical Reviews in Immunology 15 (2): 107–31. doi:10.1615/critrevimmunol.v15.i2.10. PMID 8573284. 
  • Beil WJ, Schulz M, Wefelmeyer U (Jul 2000). "Mast cell granule composition and tissue location--a close correlation". Histology and Histopathology 15 (3): 937–46. PMID 10963136. 
  • Yamamoto T (Jan 2007). "Roles of the ribosomal protein S19 dimer and the C5a receptor in pathophysiological functions of phagocytic leukocytes". Pathology International 57 (1): 1–11. doi:10.1111/j.1440-1827.2007.02049.x. PMID 17199736. 
  • Bao L, Gerard NP, Eddy RL, Shows TB, Gerard C (Jun 1992). "Mapping of genes for the human C5a receptor (C5AR), human FMLP receptor (FPR), and two FMLP receptor homologue orphan receptors (FPRH1, FPRH2) to chromosome 19". Genomics 13 (2): 437–40. doi:10.1016/0888-7543(92)90265-T. PMID 1612600. 
  • Gerard NP, Gerard C (Feb 1991). "The chemotactic receptor for human C5a anaphylatoxin". Nature 349 (6310): 614–7. doi:10.1038/349614a0. PMID 1847994. 
  • Boulay F, Mery L, Tardif M, Brouchon L, Vignais P (Mar 1991). "Expression cloning of a receptor for C5a anaphylatoxin on differentiated HL-60 cells". Biochemistry 30 (12): 2993–9. doi:10.1021/bi00226a002. PMID 2007135. 
  • Wahl SM, Allen JB, Gartner S, Orenstein JM, Popovic M, Chenoweth DE, Arthur LO, Farrar WL, Wahl LM (May 1989). "HIV-1 and its envelope glycoprotein down-regulate chemotactic ligand receptors and chemotactic function of peripheral blood monocytes". Journal of Immunology 142 (10): 3553–9. PMID 2541200. 
  • Foreman KE, Vaporciyan AA, Bonish BK, Jones ML, Johnson KJ, Glovsky MM, Eddy SM, Ward PA (Sep 1994). "C5a-induced expression of P-selectin in endothelial cells". The Journal of Clinical Investigation 94 (3): 1147–55. doi:10.1172/JCI117430. PMC 295185. PMID 7521884. 
  • Giannini E, Brouchon L, Boulay F (Aug 1995). "Identification of the major phosphorylation sites in human C5a anaphylatoxin receptor in vivo". The Journal of Biological Chemistry 270 (32): 19166–72. doi:10.1074/jbc.270.32.19166. PMID 7642584. 
  • Buhl AM, Osawa S, Johnson GL (Aug 1995). "Mitogen-activated protein kinase activation requires two signal inputs from the human anaphylatoxin C5a receptor". The Journal of Biological Chemistry 270 (34): 19828–32. doi:10.1074/jbc.270.34.19828. PMID 7649993. 
  • Wennogle LP, Conder L, Winter C, Braunwalder A, Vlattas S, Kramer R, Cioffi C, Hu SI (Jul 1994). "Stabilization of C5a receptor--G-protein interactions through ligand binding". Journal of Cellular Biochemistry 55 (3): 380–8. doi:10.1002/jcb.240550316. PMID 7962171. 
  • Gerard NP, Bao L, Xiao-Ping H, Eddy RL, Shows TB, Gerard C (Feb 1993). "Human chemotaxis receptor genes cluster at 19q13.3-13.4. Characterization of the human C5a receptor gene". Biochemistry 32 (5): 1243–50. doi:10.1021/bi00056a007. PMID 8383526. 
  • Ames RS, Li Y, Sarau HM, Nuthulaganti P, Foley JJ, Ellis C, Zeng Z, Su K, Jurewicz AJ, Hertzberg RP, Bergsma DJ, Kumar C (Aug 1996). "Molecular cloning and characterization of the human anaphylatoxin C3a receptor". The Journal of Biological Chemistry 271 (34): 20231–4. doi:10.1074/jbc.271.34.20231. PMID 8702752. 
  • Werfel T, Zwirner J, Oppermann M, Sieber A, Begemann G, Drommer W, Kapp A, Götze O (Aug 1996). "CD88 antibodies specifically bind to C5aR on dermal CD117+ and CD14+ cells and react with a desmosomal antigen in human skin". Journal of Immunology 157 (4): 1729–35. PMID 8759762. 
  • Höpken UE, Lu B, Gerard NP, Gerard C (Sep 1996). "The C5a chemoattractant receptor mediates mucosal defence to infection". Nature 383 (6595): 86–9. doi:10.1038/383086a0. PMID 8779720. 
  • Chen Z, Zhang X, Gonnella NC, Pellas TC, Boyar WC, Ni F (Apr 1998). "Residues 21-30 within the extracellular N-terminal region of the C5a receptor represent a binding domain for the C5a anaphylatoxin". The Journal of Biological Chemistry 273 (17): 10411–9. doi:10.1074/jbc.273.17.10411. PMID 9553099. 
  • Floreani AA, Heires AJ, Welniak LA, Miller-Lindholm A, Clark-Pierce L, Rennard SI, Morgan EL, Sanderson SD (May 1998). "Expression of receptors for C5a anaphylatoxin (CD88) on human bronchial epithelial cells: enhancement of C5a-mediated release of IL-8 upon exposure to cigarette smoke". Journal of Immunology 160 (10): 5073–81. PMID 9590258. 
  • Ottonello L, Corcione A, Tortolina G, Airoldi I, Albesiano E, Favre A, D'Agostino R, Malavasi F, Pistoia V, Dallegri F (Jun 1999). "rC5a directs the in vitro migration of human memory and naive tonsillar B lymphocytes: implications for B cell trafficking in secondary lymphoid tissues". Journal of Immunology 162 (11): 6510–7. PMID 10352266. 
  • Kohleisen B, Shumay E, Sutter G, Foerster R, Brack-Werner R, Nuesse M, Erfle V (Dec 1999). "Stable expression of HIV-1 Nef induces changes in growth properties and activation state of human astrocytes". Aids 13 (17): 2331–41. doi:10.1097/00002030-199912030-00004. PMID 10597774. 
  • Monk PN, Scola AM, Madala P, Fairlie DP (Oct 2007). "Function, structure and therapeutic potential of complement C5a receptors". British Journal of Pharmacology 152 (4): 429–48. doi:10.1038/sj.bjp.0707332. PMC 2050825. PMID 17603557. 

External links[edit]