Integrin, alpha M (complement component 3 receptor 3 subunit)
rendering based on 1bho.
PDB Ortholog search:
List of PDB id codes
, 1A8X , 1BHO , 1BHQ , 1IDN , 1IDO , 1JLM , 1M1U , 1MF7 , 1N9Z , 1NA5 , 2LKE , 2LKJ , 3Q3G , 3QA3 4M76
; CD11B; CR3A; MAC-1; MAC1A; MO1A; SLEB6 ITGAM
OMIM: 120980 MGI: 96607 HomoloGene: 526 IUPHAR: 2452 ChEMBL: 3826 GeneCards: ITGAM Gene
RNA expression pattern
More reference expression data
31.27 – 31.34 Mb
128.06 – 128.13 Mb
Integrin alpha M (ITGAM) is one protein subunit that forms the heterodimeric integrin alpha-M beta-2 (α Mβ 2) molecule, also known as (Mac-1) or macrophage-1 antigen (CR3). complement receptor 3 ITGAM is also known as CR3A, and [1 ] cluster of differentiation molecule 11B (CD11B). The second chain of α Mβ 2 is the common integrin β 2 subunit known as CD18, and integrin α Mβ 2 thus belongs to the β 2 subfamily (or leukocyte) integrins. [2 ]
Mβ 2 is expressed on the surface of many leukocytes involved in the innate immune system, including monocytes, granulocytes, macrophages, and natural killer cells. It mediates inflammation by regulating leukocyte [1 ] adhesion and migration and has been implicated in several immune processes such as phagocytosis, cell-mediated cytotoxicity, chemotaxis and cellular activation. It is involved in the [1 ] complement system due to its capacity to bind inactivated complement component 3b (iC3b). The ITGAM (alpha) subunit of integrin α [3 ] Mβ 2 is directly involved in causing the adhesion and spreading of cells but cannot mediate cellular migration without the presence of the β2 (CD18) subunit. [1 ]
In genomewide association studies, single nucleotide polymorphisms in ITGAM had the strongest association with
systemic lupus erythematosus, with an odds ratio of 1.65 for the T allele of rs9888739 and lupus. [4 ] [5 ]
histopathology, immunohistochemistry with antibodies against CD11B is frequently used to identify macrophages and microglia.
See also [ edit ]
References [ edit ]
^ a b c d Solovjov D, Pluskota E, Plow E (2005). "Distinct roles for the alpha and beta subunits in the functions of integrin alphaMbeta2". J Biol Chem 280 (2): 1336–45. doi: 10.1074/jbc.M406968200. PMID 15485828.
^ Larson R, Springer T (1990). "Structure and function of leukocyte integrins". Immunol Rev 114: 181–217. doi: 10.1111/j.1600-065X.1990.tb00565.x. PMID 2196220.
^ Arnaout M, Todd R, Dana N, Melamed J, Schlossman S, Colten H (1983). "Inhibition of phagocytosis of complement C3- or immunoglobulin G-coated particles and of C3bi binding by monoclonal antibodies to a monocyte-granulocyte membrane glycoprotein (Mol)". J Clin Invest 72 (1): 171–9. doi: 10.1172/JCI110955. PMC 1129172. PMID 6874946.
^ Mary K. Crow (February 28, 2008). "Collaboration, Genetic Associations, and Lupus Erythematosus". N Engl J Med 358 (9): 956–961. doi: 10.1056/NEJMe0800096. PMID 18204099.
^ Geoffrey Hom, Robert R. Graham, Barmak Modrek et al. (February 28, 2008). "Association of Systemic Lupus Erythematosus with C8orf13–BLK and ITGAM–ITGAX". N Engl J Med 358 (9): 900–909. doi: 10.1056/NEJMoa0707865. PMID 18204098.
Further reading [ edit ]
1bho: MAC-1 I DOMAIN MAGNESIUM COMPLEX
1bhq: MAC-1 I DOMAIN CADMIUM COMPLEX
1idn: MAC-1 I DOMAIN METAL FREE
1ido: I-DOMAIN FROM INTEGRIN CR3, MG2+ BOUND
1jlm: I-DOMAIN FROM INTEGRIN CR3, MN2+ BOUND
1m1u: AN ISOLEUCINE-BASED ALLOSTERIC SWITCH CONTROLS AFFINITY AND SHAPE SHIFTING IN INTEGRIN CD11B A-DOMAIN
1mf7: INTEGRIN ALPHA M I DOMAIN
1n9z: INTEGRIN ALPHA M I DOMAIN MUTANT
1na5: INTEGRIN ALPHA M I DOMAIN
External links [ edit ]