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CD59 molecule, complement regulatory protein
Protein CD59 PDB 1cdq.png
PDB rendering based on 1cdq.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols CD59 ; 16.3A5; 1F5; EJ16; EJ30; EL32; G344; HRF-20; HRF20; MAC-IP; MACIF; MEM43; MIC11; MIN1; MIN2; MIN3; MIRL; MSK21; p18-20
External IDs OMIM107271 MGI1888996 HomoloGene56386 GeneCards: CD59 Gene
RNA expression pattern
PBB GE CD59 200984 s at tn.png
PBB GE CD59 200983 x at tn.png
PBB GE CD59 200985 s at tn.png
More reference expression data
Species Human Mouse
Entrez 966 333883
Ensembl ENSG00000085063 ENSMUSG00000068686
UniProt P13987 P58019
RefSeq (mRNA) NM_000611 NM_181858
RefSeq (protein) NP_000602 NP_862906
Location (UCSC) Chr 11:
33.7 – 33.74 Mb
Chr 2:
104.07 – 104.09 Mb
PubMed search [1] [2]

CD59 glycoprotein also known as MAC-inhibitory protein (MAC-IP), membrane inhibitor of reactive lysis (MIRL), or protectin, is a protein that in humans is encoded by the CD59 gene.[1]

CD59 attaches to host cells via a glycophosphatidylinositol (GPI) anchor. When complement activation leads to deposition of C5b678 on host cells, CD59 can prevent C9 from polymerizing and forming the complement membrane attack complex.[2] Mutations affecting GPI that reduce expression of CD59 and decay-accelerating factor on red blood cells result in paroxysmal nocturnal hemoglobinuria.[3]

Viruses such as HIV, human cytomegalovirus and vaccinia incorporate host cell CD59 into their own viral envelope to prevent lysis by complement.[4]


  1. ^ "Entrez Gene: CD59 molecule, complement regulatory protein". 
  2. ^ Huang Y, Qiao F, Abagyan R, Hazard S, Tomlinson S (September 2006). "Defining the CD59-C9 binding interaction". J. Biol. Chem. 281 (37): 27398–27404. doi:10.1074/jbc.M603690200. PMID 16844690. 
  3. ^ Parker C, Omine M, Richards S; et al. (2005). "Diagnosis and management of paroxysmal nocturnal hemoglobinuria". Blood 106 (12): 3699–709. doi:10.1182/blood-2005-04-1717. PMC 1895106. PMID 16051736. 
  4. ^ Bohana-Kashtan O, Ziporen L, Donin N, Kraus S, Fishelson Z (July 2004). "Cell signals transduced by complement". Mol. Immunol. 41 (6–7): 583–597. doi:10.1016/j.molimm.2004.04.007. PMID 15219997. 

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