Sphinganine C4-monooxygenase
| Sphinganine C4-monooxygenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.14.13.169 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Sphinganine C4-monooxygenase (EC 1.14.13.169, sphingolipid C4-hydroxylase, SUR2 (gene), SBH1 (gene), SBH2 (gene)) is an enzyme with systematic name sphinganine,NADPH:oxygen oxidoreductase (C4-hydroxylating).[1][2][3] This enzyme catalyses the following chemical reaction
- sphinganine + NADPH + H+ + O2 phytosphingosine + NADP+ + H2O
Sphinganine C4-monooxygenase is involved in the biosynthesis of sphingolipids in yeast and plants.
References
- ^ Haak D, Gable K, Beeler T, Dunn T (November 1997). "Hydroxylation of Saccharomyces cerevisiae ceramides requires Sur2p and Scs7p". The Journal of Biological Chemistry. 272 (47): 29704–10. doi:10.1074/jbc.272.47.29704. PMID 9368039.
- ^ Grilley MM, Stock SD, Dickson RC, Lester RL, Takemoto JY (May 1998). "Syringomycin action gene SYR2 is essential for sphingolipid 4-hydroxylation in Saccharomyces cerevisiae". The Journal of Biological Chemistry. 273 (18): 11062–8. doi:10.1074/jbc.273.18.11062. PMID 9556590.
- ^ Sperling P, Ternes P, Moll H, Franke S, Zähringer U, Heinz E (April 2001). "Functional characterization of sphingolipid C4-hydroxylase genes from Arabidopsis thaliana". FEBS Letters. 494 (1–2): 90–4. doi:10.1016/s0014-5793(01)02332-8. PMID 11297741.
External links
- Sphinganine+C4-monooxygenase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
