ADCY10

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ADCY10
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases ADCY10, HCA2, SAC, SACI, Sacy, hsAC, HEL-S-7a, adenylate cyclase 10 (soluble)
External IDs MGI: 2660854 HomoloGene: 10188 GeneCards: ADCY10
RNA expression pattern
PBB GE SAC 214547 at fs.png

PBB GE SAC 217305 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001167749
NM_001297772
NM_018417

NM_173029

RefSeq (protein)

NP_001161221
NP_001284701
NP_060887

NP_766617.2
NP_766617

Location (UCSC) Chr 1: 167.81 – 167.91 Mb Chr 1: 165.49 – 165.58 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Adenylyl cyclase 10 also known as ADCY10 is an enzyme that, in humans, is encoded by the ADCY10 gene.[3]

Function[edit]

The protein encoded by this gene belongs to a distinct class of mammalian adenylyl cyclase that is soluble and insensitive to G protein or forskolin regulation. It is localized in the cytoplasm and is thought to function as a general bicarbonate sensor throughout the body. It may also play an important role in the generation of cAMP in spermatozoa, implying possible roles in sperm maturation through the epididymis, capacitation, hypermotility, and/or the acrosome reaction.[4]

Clinical significance[edit]

Mutations in the ADCY10 gene are associated with an increased risk of adsorptive hypercalciuria.[3]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ a b Reed BY, Heller HJ, Gitomer WL, Pak CY (November 1999). "Mapping a gene defect in absorptive hypercalciuria to chromosome 1q23.3-q24". J. Clin. Endocrinol. Metab. 84 (11): 3907–13. doi:10.1210/jc.84.11.3907. PMID 10566627. 
  4. ^ "Entrez Gene: ADCY10". 

External links[edit]

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.