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ADCY1

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ADCY1
Identifiers
AliasesADCY1, AC1, DFNB44, adenylate cyclase 1 (brain), adenylate cyclase 1
External IDsOMIM: 103072; MGI: 99677; HomoloGene: 41419; GeneCards: ADCY1; OMA:ADCY1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001281768
NM_021116

NM_009622

RefSeq (protein)

NP_001268697
NP_066939

NP_033752

Location (UCSC)Chr 7: 45.57 – 45.72 MbChr 11: 7.01 – 7.13 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Adenylyl cyclase type 1 is an enzyme that in humans is encoded by the ADCY1 gene.[5][6]

This gene encodes a form of adenylyl cyclase expressed in the brain. A similar protein in mice is involved in pattern formation of the brain.[6]

Function

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ADCY1 is a calmodulin-sensitive adenylyl cyclase. In terms of function, It may be involved in regulatory processes in the central nervous system; specifically, it may play a role in memory acquisition and learning. It is inhibited by the G protein beta and gamma subunit complex.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000164742Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020431Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Villacres EC, Xia Z, Bookbinder LH, Edelhoff S, Disteche CM, Storm DR (May 1993). "Cloning, chromosomal mapping, and expression of human fetal brain type I adenylyl cyclase". Genomics. 16 (2): 473–8. doi:10.1006/geno.1993.1213. PMID 8314585.
  6. ^ a b "Entrez Gene: ADCY1 adenylyl cyclase 1 (brain)".
  7. ^ "Gene Cards: ADCY1 Gene". Retrieved 2012-12-30.
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Further reading

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