Bromide peroxidase

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Bromide peroxidase
EC number
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Bromide peroxidase (EC, bromoperoxidase, haloperoxidase (ambiguous), eosinophil peroxidase) is an enzyme with systematic name bromide:hydrogen-peroxide oxidoreductase.[1][2][3][4][5] This enzyme catalyses the following chemical reaction

RH + HBr + H2O2 RBr + 2 H2O

Bromo peroxidases of red and brown marine algae (Rhodophyta and Phaeophyta) contain vanadate.


  1. ^ De Boer, E.; Tromp, M.G.M.; Plat, H.; Krenn, G.E.; Wever, R (1986). "Vanadium(v) as an essential element for haloperoxidase activity in marine brown-algae - purification and characterization of a vanadium(V)-containing bromoperoxidase from Laminaria saccharina". Biochim. Biophys. Acta. 872: 104–115. doi:10.1016/0167-4838(86)90153-6. 
  2. ^ Tromp, M.G.; Olafsson, G.; Krenn, B.E.; Wever, R. (1990). "Some structural aspects of vanadium bromoperoxidase from Ascophyllum nodosum". Biochim. Biophys. Acta. 1040 (2): 192–198. PMID 2400770. doi:10.1016/0167-4838(90)90075-q. 
  3. ^ Isupov, M.N.; Dalby, A.R.; Brindley, A.A.; Izumi, Y.; Tanabe, T.; Murshudov, G.N.; Littlechild, J.A. (2000). "Crystal structure of dodecameric vanadium-dependent bromoperoxidase from the red algae Corallina officinalis". J. Mol. Biol. 299: 1035–1049. PMID 10843856. doi:10.1006/jmbi.2000.3806. 
  4. ^ Carter-Franklin, J.N.; Butler, A. (2004). "Vanadium bromoperoxidase-catalyzed biosynthesis of halogenated marine natural products". J. Am. Chem. Soc. 126: 15060–15066. PMID 15548002. doi:10.1021/ja047925p. 
  5. ^ Ohshiro, T.; Littlechild, J.; Garcia-Rodriguez, E.; Isupov, M.N.; Iida, Y.; Kobayashi, T.; Izumi, Y. (2004). "Modification of halogen specificity of a vanadium-dependent bromoperoxidase". Protein Sci. 13: 1566–1571. PMC 2279980Freely accessible. PMID 15133166. doi:10.1110/ps.03496004. 

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