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Glutathione peroxidase 6
Symbols GPX6 ; GPX5p; GPXP3; GPx-6; GSHPx-6; dJ1186N24; dJ1186N24.1
External IDs OMIM607913 MGI1922762 HomoloGene130008 GeneCards: GPX6 Gene
EC number
Species Human Mouse
Entrez 257202 75512
Ensembl ENSG00000198704 ENSMUSG00000004341
UniProt P59796 Q91WR8
RefSeq (mRNA) NM_182701 NM_145451
RefSeq (protein) NP_874360 NP_663426
Location (UCSC) Chr 6:
28.5 – 28.53 Mb
Chr 13:
21.31 – 21.32 Mb
PubMed search [1] [2]

Glutathione peroxidase 6 (GPx-6) is an enzyme that in humans is encoded by the GPX6 gene.[1][2]

This gene product belongs to the glutathione peroxidase family, which functions in the detoxification of hydrogen peroxide. It contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Expression of this gene is restricted to embryos and adult olfactory epithelium.[1]


  1. ^ a b "Entrez Gene: glutathione peroxidase 6 (olfactory)". 
  2. ^ Kryukov GV, Castellano S, Novoselov SV, Lobanov AV, Zehtab O, Guigó R, Gladyshev VN (May 2003). "Characterization of mammalian selenoproteomes". Science 300 (5624): 1439–43. doi:10.1126/science.1083516. PMID 12775843. 

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