CRLF2

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Cytokine receptor-like factor 2
Identifiers
Symbols CRLF2 ; CRL2; CRLF2Y; TSLPR
External IDs OMIM400023 MGI1889506 HomoloGene49476 IUPHAR: 1704 GeneCards: CRLF2 Gene
Orthologs
Species Human Mouse
Entrez 64109 57914
Ensembl ENSG00000205755 ENSMUSG00000033467
UniProt Q9HC73 Q8CII9
RefSeq (mRNA) NM_001012288 NM_001164735
RefSeq (protein) NP_001012288 NP_001158207
Location (UCSC) Chr X:
1.31 – 1.33 Mb
Chr 5:
109.55 – 109.56 Mb
PubMed search [1] [2]

Cytokine receptor-like factor 2 is a protein that in humans is encoded by the CRLF2 gene.[1][2][3]

Cytokine signals are mediated through specific receptor complexes, the components of which are mostly members of the type I cytokine receptor family. Type I cytokine receptors share conserved structural features in their extracellular domain. Receptor complexes are typically heterodimeric, consisting of alpha chains, which provide ligand specificity, and beta (or gamma) chains, which are required for the formation of high-affinity binding sites and signal transduction.[supplied by OMIM][3]

References[edit]

  1. ^ Zhang W, Wang J, Wang Q, Chen G, Zhang J, Chen T, Wan T, Zhang Y, Cao X (Mar 2001). "Identification of a novel type I cytokine receptor CRL2 preferentially expressed by human dendritic cells and activated monocytes". Biochem Biophys Res Commun 281 (4): 878–83. doi:10.1006/bbrc.2001.4432. PMID 11237741. 
  2. ^ Tonozuka Y, Fujio K, Sugiyama T, Nosaka T, Hirai M, Kitamura T (Jul 2001). "Molecular cloning of a human novel type I cytokine receptor related to delta1/TSLPR". Cytogenet Cell Genet 93 (1–2): 23–5. doi:10.1159/000056941. PMID 11474172. 
  3. ^ a b "Entrez Gene: CRLF2 cytokine receptor-like factor 2". 

Further reading[edit]

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
  • Hiroyama T, Iwama A, Morita Y et al. (2000). "Molecular cloning and characterization of CRLM-2, a novel type I cytokine receptor preferentially expressed in hematopoietic cells". Biochem. Biophys. Res. Commun. 272 (1): 224–9. doi:10.1006/bbrc.2000.2764. PMID 10872831. 
  • Reche PA, Soumelis V, Gorman DM et al. (2001). "Human thymic stromal lymphopoietin preferentially stimulates myeloid cells". J. Immunol. 167 (1): 336–43. doi:10.4049/jimmunol.167.1.336. PMID 11418668. 
  • Blagoev B, Nielsen MM, Angrist M et al. (2002). "Cloning of rat thymic stromal lymphopoietin receptor (TSLPR) and characterization of genomic structure of murine Tslpr gene". Gene 284 (1–2): 161–8. doi:10.1016/S0378-1119(02)00380-3. PMID 11891057. 
  • Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Rochman I, Watanabe N, Arima K et al. (2007). "Cutting edge: direct action of thymic stromal lymphopoietin on activated human CD4+ T cells". J. Immunol. 178 (11): 6720–4. doi:10.4049/jimmunol.178.11.6720. PMID 17513717.