Cardiaxx was developed by David Mariner and Jon Mitchell of Eclipse Design, with Joe Karthouser later joining them. The game's original publisher, Electronic Zoo, failed to release funds owed to Eclipse Design for its development shortly after its public release in 1991. As a result, the Atari ST version was never released, and legal action followed. However, Electronic Zoo closed down during the legal proceedings. The game was later released by Team17, but again no funds beyond the initial signing fee were ever released. Therefore, Mariner and Mitchell still retain all rights to Cardiaxx to this day.