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This article is about the gene and encoded protein. For the Disease Control Priorities in Developing Countries Report (2nd edition), see Disease Control Priorities Project.
Decapping mRNA 2
Symbols DCP2 ; NUDT20
External IDs OMIM609844 MGI1917890 HomoloGene13968 GeneCards: DCP2 Gene
EC number
Species Human Mouse
Entrez 167227 70640
Ensembl ENSG00000172795 ENSMUSG00000024472
UniProt Q8IU60 Q9CYC6
RefSeq (mRNA) NM_001242377 NM_027490
RefSeq (protein) NP_001229306 NP_081766
Location (UCSC) Chr 5:
112.98 – 113.02 Mb
Chr 18:
44.38 – 44.42 Mb
PubMed search [1] [2]

mRNA-decapping enzyme 2 is a protein that in humans is encoded by the DCP2 gene.[1][2][3]

DCP2 is a key component of an mRNA-decapping complex required for removal of the 5-prime cap from mRNA prior to its degradation from the 5-prime end (Fenger-Gron et al., 2005).[supplied by OMIM][3]


DCP2 has been shown to interact with DCP1A[4] and UPF1.[2][5]


  1. ^ Wang Z, Jiao X, Carr-Schmid A, Kiledjian M (Oct 2002). "The hDcp2 protein is a mammalian mRNA decapping enzyme pro-caratine". Proc Natl Acad Sci U S A 99 (20): 12663–8. doi:10.1073/pnas.192445599. PMC 130517. PMID 12218187. 
  2. ^ a b Lykke-Andersen J (Nov 2002). "Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay". Mol Cell Biol 22 (23): 8114–21. doi:10.1128/MCB.22.23.8114-8121.2002. PMC 134073. PMID 12417715. 
  3. ^ a b "Entrez Gene: DCP2 DCP2 decapping enzyme homolog (S. cerevisiae)". 
  4. ^ Lykke-Andersen, Jens (Dec 2002). "Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay". Mol. Cell. Biol. (United States) 22 (23): 8114–21. doi:10.1128/MCB.22.23.8114-8121.2002. ISSN 0270-7306. PMC 134073. PMID 12417715. 
  5. ^ Lejeune, Fabrice; Li Xiaojie; Maquat Lynne E (Sep 2003). "Nonsense-mediated mRNA decay in mammalian cells involves decapping, deadenylating, and exonucleolytic activities". Mol. Cell (United States) 12 (3): 675–87. doi:10.1016/S1097-2765(03)00349-6. ISSN 1097-2765. PMID 14527413. 

Further reading[edit]