DCP2

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This article is about the gene and encoded protein. For the Disease Control Priorities in Developing Countries Report (2nd edition), see Disease Control Priorities Project.
DCP2
Identifiers
Aliases DCP2, NUDT20, decapping mRNA 2
External IDs MGI: 1917890 HomoloGene: 13968 GeneCards: 167227
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001242377
NM_152624

NM_027490

RefSeq (protein)

NP_001229306.1
NP_689837.2

NP_081766.1

Location (UCSC) Chr 5: 112.98 – 113.02 Mb Chr 18: 44.38 – 44.42 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

mRNA-decapping enzyme 2 is a protein that in humans is encoded by the DCP2 gene.[1][2][3]

DCP2 is a key component of an mRNA-decapping complex required for removal of the 5-prime cap from mRNA prior to its degradation from the 5-prime end (Fenger-Gron et al., 2005).[supplied by OMIM][3]

Interactions[edit]

DCP2 has been shown to interact with DCP1A[4] and UPF1.[2][5]

References[edit]

  1. ^ Wang Z, Jiao X, Carr-Schmid A, Kiledjian M (Oct 2002). "The hDcp2 protein is a mammalian mRNA decapping enzyme pro-caratine". Proc Natl Acad Sci U S A 99 (20): 12663–8. doi:10.1073/pnas.192445599. PMC 130517. PMID 12218187. 
  2. ^ a b Lykke-Andersen J (Nov 2002). "Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay". Mol Cell Biol 22 (23): 8114–21. doi:10.1128/MCB.22.23.8114-8121.2002. PMC 134073. PMID 12417715. 
  3. ^ a b "Entrez Gene: DCP2 DCP2 decapping enzyme homolog (S. cerevisiae)". 
  4. ^ Lykke-Andersen, Jens (Dec 2002). "Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay". Mol. Cell. Biol. (United States) 22 (23): 8114–21. doi:10.1128/MCB.22.23.8114-8121.2002. ISSN 0270-7306. PMC 134073. PMID 12417715. 
  5. ^ Lejeune, Fabrice; Li Xiaojie; Maquat Lynne E (Sep 2003). "Nonsense-mediated mRNA decay in mammalian cells involves decapping, deadenylating, and exonucleolytic activities". Mol. Cell (United States) 12 (3): 675–87. doi:10.1016/S1097-2765(03)00349-6. ISSN 1097-2765. PMID 14527413. 

Further reading[edit]