Fatty acid-binding protein
The fatty-acid-binding proteins (FABPs) are a family of transport proteins for fatty acids and other lipophilic substances such as eicosanoids and retinoids.[1][2] These proteins are thought to facilitate the transfer of fatty acids between extra- and intracellular membranes.[3] Some family members are also believed to transport lipophilic molecules from outer cell membrane to certain intracellular receptors such as PPAR.[4] Levels of fatty-acid-binding protein have been shown to decline with ageing in the mouse brain, possibly contributing to age-associated decline in synaptic activity.[5]
Family members
Members of this family include:
| Protein name | Gene | Tissue distribution | Comment |
|---|---|---|---|
| FABP 1 | FABP1 | liver | |
| FABP 2 | FABP2 | intestinal | |
| FABP 3 | FABP3 | muscle and heart | mammary-derived growth inhibitor |
| FABP 4 | FABP4 | adipocyte | |
| FABP 5 | FABP5 | epidermal | psoriasis-associated |
| FABP 6 | FABP6 | ileal | gastrotropin |
| FABP 7 | FABP7 | brain | |
| FABP 8 | PMP2 | peripheral nervous system | peripheral myelin protein 2 |
| FABP 9 | FABP9 | ||
| FABP 11 | fabp11 | restricted to fishes | |
| FABP 12 | FABP12 | presence shown in human retinoblastoma cell lines, rodent retina and testis.[6] | |
| FABP 5-like 1 | FABP5L1 | ||
| FABP 5-like 2 | FABP5L2 | ||
| FABP 5-like 3 | FABP5L3 | ||
| FABP 5-like 4 | FABP5L4 | ||
| FABP 5-like 5 | FABP5L5 | ||
| FABP 5-like 6 | FABP5L6 | ||
| FABP 5-like 7 | FABP5L7 |
References
- ^ Chmurzyńska A (2006). "The multigene family of fatty acid-binding proteins (FABPs): function, structure and polymorphism". Journal of Applied Genetics. 47 (1): 39–48. doi:10.1007/BF03194597. PMID 16424607.
- ^ Smathers RL, Petersen DR (Mar 2011). "The human fatty acid-binding protein family: evolutionary divergences and functions". Human Genomics. 5 (3): 170–191. doi:10.1186/1479-7364-5-3-170. PMC 3500171. PMID 21504868.
{{cite journal}}: CS1 maint: unflagged free DOI (link) - ^ Weisiger RA (Oct 2002). "Cytosolic fatty acid binding proteins catalyze two distinct steps in intracellular transport of their ligands". Molecular and Cellular Biochemistry. 239 (1–2): 35–43. doi:10.1023/A:1020550405578. PMID 12479566.
- ^ Tan NS, Shaw NS, Vinckenbosch N, Liu P, Yasmin R, Desvergne B, Wahli W, Noy N (Jul 2002). "Selective cooperation between fatty acid binding proteins and peroxisome proliferator-activated receptors in regulating transcription". Molecular and Cellular Biology. 22 (14): 5114–27. doi:10.1128/MCB.22.14.5114-5127.2002. PMC 139777. PMID 12077340.
- ^ Pu L, Igbavboa U, Wood WG, Roths JB, Kier AB, Spener F, Schroeder F (Aug 1999). "Expression of fatty acid binding proteins is altered in aged mouse brain". Molecular and Cellular Biochemistry. 198 (1–2): 69–78. doi:10.1023/A:1006946027619. PMID 10497880.
- ^ Liu RZ, Li X, Godbout R (Dec 2008). "A novel fatty acid-binding protein (FABP) gene resulting from tandem gene duplication in mammals: transcription in rat retina and testis". Genomics. 92 (6). doi:10.1016/j.ygeno.2008.08.003. PMID 18786628.
External links
- Fatty+Acid-Binding+Proteins at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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