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Gamma-glutamyl hydrolase

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Ghk.

Gamma-glutamyl hydrolase
Identifiers
EC no.3.4.19.9
CAS no.9074-87-7
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Search
PMCarticles
PubMedarticles
NCBIproteins
GGH
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesGGH, GH, gamma-glutamyl hydrolase, GATD10
External IDsOMIM: 601509; MGI: 1329035; HomoloGene: 2881; GeneCards: GGH; OMA:GGH - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003878

NM_010281

RefSeq (protein)

NP_003869

NP_034411

Location (UCSC)Chr 8: 63.01 – 63.04 MbChr 4: 20.04 – 20.07 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Gamma-glutamyl hydrolase is an enzyme[5][6][7][8] that catalyses the following chemical reaction:

Hydrolysis of a gamma-glutamyl bond

This lysosomal or secreted, thiol-dependent peptidase, most active at acidic pH.

In humans, gamma-glutamyl hydrolase is encoded by the GGH gene.[7][9][10] This gene catalyzes the hydrolysis of folylpoly-gamma-glutamates and antifolylpoly-gamma-glutamates by the removal of gamma-linked polyglutamates and glutamate.[10]

Nomenclature

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Gamma-glutamyl hydrolase is also known as conjugase, folate conjugase, lysosomal gamma-glutamyl carboxypeptidase, gamma-Glu-X carboxypeptidase, pteroyl-poly-gamma-glutamate hydrolase, carboxypeptidase G, folic acid conjugase, poly(gamma-glutamic acid) endohydrolase, polyglutamate hydrolase, poly(glutamic acid) hydrolase II, pteroylpoly-gamma-glutamyl hydrolase.

Interactive pathway map

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Click on genes, proteins and metabolites below to link to respective articles.[§ 1]

[[File:
FluoropyrimidineActivity_WP1601go to articlego to articlego to articlego to pathway articlego to pathway articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to PubChem Compoundgo to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to pathway articlego to pathway articlego to articlego to articlego to articlego to articlego to articlego to WikiPathwaysgo to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to article
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FluoropyrimidineActivity_WP1601go to articlego to articlego to articlego to pathway articlego to pathway articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to PubChem Compoundgo to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to pathway articlego to pathway articlego to articlego to articlego to articlego to articlego to articlego to WikiPathwaysgo to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to article
|alt=Fluorouracil (5-FU) Activity edit]]
Fluorouracil (5-FU) Activity edit
  1. ^ The interactive pathway map can be edited at WikiPathways: "FluoropyrimidineActivity_WP1601".

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000137563Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000073987Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Wang Y, Nimec Z, Ryan TJ, Dias JA, Galivan J (August 1993). "The properties of the secreted gamma-glutamyl hydrolases from H35 hepatoma cells". Biochim. Biophys. Acta. 1164 (3): 227–35. doi:10.1016/0167-4838(93)90253-n. PMID 8343522.
  6. ^ Yao R, Rhee MS, Galivan J (September 1995). "Effects of gamma-glutamyl hydrolase on folyl and antifolylpolyglutamates in cultured H35 hepatoma cells". Mol. Pharmacol. 48 (3): 505–11. PMID 7565632.
  7. ^ a b Yao R, Schneider E, Ryan TJ, Galivan J (September 1996). "Human gamma-glutamyl hydrolase: cloning and characterization of the enzyme expressed in vitro". Proc. Natl. Acad. Sci. U.S.A. 93 (19): 10134–8. Bibcode:1996PNAS...9310134Y. doi:10.1073/pnas.93.19.10134. PMC 38349. PMID 8816764.
  8. ^ Yao R, Nimec Z, Ryan TJ, Galivan J (April 1996). "Identification, cloning, and sequencing of a cDNA coding for rat gamma-glutamyl hydrolase". J. Biol. Chem. 271 (15): 8525–8. doi:10.1074/jbc.271.15.8525. PMID 8621474.
  9. ^ Yin D, Chave KJ, Macaluso CR, Galivan J, Yao R (Dec 1999). "Structural organization of the human gamma-glutamyl hydrolase gene". Gene. 238 (2): 463–70. doi:10.1016/S0378-1119(99)00362-5. PMID 10570974.
  10. ^ a b "Entrez Gene: GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)". Archived from the original on 2022-12-12. Retrieved 2017-08-31.

Further reading

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