Glutathione peroxidase 7

GPX7
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2P31
Identifiers
Aliases	GPX7, CL683, GPX6, GPx-7, GSHPx-7, NPGPx, glutathione peroxidase 7
External IDs	OMIM: 615784; MGI: 1914555; HomoloGene: 128491; GeneCards: GPX7; OMA:GPX7 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	52,609,051 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	108,264,158 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; cartilage tissue; ; ganglionic eminence; ; periodontal fiber; ; gallbladder; ; granulocyte; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; anterior pituitary; ; left uterine tube;
	Top expressed in
	external naris; ; calvaria; ; dermis; ; intervertebral disc; ; efferent ductule; ; cervical vertebral column; ; external carotid artery; ; fossa; ; endocardial cushion; ; thoracic vertebral column;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	oxidoreductase activity; glutathione peroxidase activity; catalase activity; protein binding; peroxidase activity;
Cellular component	extracellular region; endoplasmic reticulum lumen; endoplasmic reticulum;
Biological process	response to oxidative stress; cellular oxidant detoxification; cellular response to oxidative stress;
	Sources:Amigo / QuickGO
Orthologs
	2882
	67305
	ENSG00000116157
	ENSMUSG00000028597
	Q96SL4
	Q99LJ6
	NM_015696
	NM_024198
	NP_056511
	NP_077160
	Wikidata
View/Edit Human	View/Edit Mouse

Glutathione peroxidase 7 is an enzyme that in humans is encoded by the GPX7 gene.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000116157 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028597 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Utomo A, Jiang X, Furuta S, Yun J, Levin DS, Wang YC, Desai KV, Green JE, Chen PL, Lee WH (Oct 2004). "Identification of a novel putative non-selenocysteine containing phospholipid hydroperoxide glutathione peroxidase (NPGPx) essential for alleviating oxidative stress generated from polyunsaturated fatty acids in breast cancer cells". J Biol Chem. 279 (42): 43522–9. doi:10.1074/jbc.M407141200. PMID 15294905.{{cite journal}}: CS1 maint: unflagged free DOI (link)
^ "Entrez Gene: GPX7 glutathione peroxidase 7".

v t e Oxidoreductases: peroxidases (EC 1.11)
1.11.1.1-14	NADH peroxidase NADPH peroxidase Fatty-acid peroxidase Catalase Cytochrome c peroxidase Eosinophil peroxidase Glutathione peroxidase GPX 1 2 3 4 5 6 7 8 Horseradish peroxidase Lactoperoxidase Myeloperoxidase Thyroid peroxidase Deiodinase Iodothyronine deiodinase Iodotyrosine deiodinase
1.11.1.15 (peroxiredoxin)	1 2 3 4 5 6

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)