When the Jinghan Railway from Beijing reached Hankou in the early 20th century, its terminus was the Hankou Dazhimen Station (大智门火车站), located right outside the walls of the bustling port city of Hankou. In 1991 the old station was closed, and services were relocated to the present Hankou Railway Station, located much further to the north from the central Hankou.
Hankou Railway Station became connected to Wuhan Metro on December 28, 2012, with the opening of Line 2 of the city's subway system.
Like the Wuchang Railway Station on the other (southern) side of the Yangtze, the Hankou station is served by trains going in all directions. After the completion of the high-speed Hewu Railway from Hefei in April 2009, the Hankou Station became the main Wuhan terminal for the express trains arriving to the city on this line from Shanghai via Nanjing and Hefei, although as of March 2010 at least one of these trains arrives to the Wuhan Railway Station instead, and some go to Wuchang.