Isopropamide

Isopropamide
Clinical data
MedlinePlus	a694006
Routes of; administration	Oral
ATC code	A03AB09 (WHO) ;
Legal status
Legal status	US: Rx-only, Unscheduled; In general: unscheduled;
Identifiers
	IUPAC name 4-amino-N,N-diisopropyl-N-methyl-4-oxo-3,3-diphenylbutan-1-aminium;
CAS Number	7492-32-2 ;
PubChem CID	3775;
DrugBank	DB01625 ;
ChemSpider	3643 ;
UNII	8B9I31H724;
ChEMBL	ChEMBL1201232 ;
CompTox Dashboard (EPA)	DTXSID9023174 ;
ECHA InfoCard	100.028.470
Chemical and physical data
Formula	C23H33N2O+
Molar mass	353.52092 g/mol g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(N)C(c1ccccc1)(c2ccccc2)CC[N+](C(C)C)(C(C)C)C;
	InChI InChI=1S/C23H32N2O/c1-18(2)25(5,19(3)4)17-16-23(22(24)26,20-12-8-6-9-13-20)21-14-10-7-11-15-21/h6-15,18-19H,16-17H2,1-5H3,(H-,24,26)/p+1 ; Key:JTPUMZTWMWIVPA-UHFFFAOYSA-O ;
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Isopropamide (R5) is a long-acting anticholinergic drug. It is used in the treatment of peptic ulcers and other gastrointestinal disorders involving hyperacidity (gastrointestinal acidosis) and hypermotility. Chemically, it contains a quaternary ammonium group. It is most often provided as an iodide salt, but is also available as a bromide or chloride salt. It was discovered at Janssen Pharmaceutica in 1954.

References

Seeherman R, Isopropamide iodide: a long-acting anticholinergic, Del Med J. 1957 Oct;29(10):265-9.
Boss EG Jr, Buchanan GC, Effect of isopropamide iodide on basal gastric secretion in the human, Gastroenterology. 1957 Nov;33(5):730-6.

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