|Trade names||Colofac, Duspamen, Duspatalin and others|
|AHFS/Drugs.com||International Drug Names|
|Chemical and physical data|
|Molar mass||429.6 g/mol|
|3D model (JSmol)|
Mebeverine is used to alleviate some of the symptoms of irritable bowel syndrome (IBS) and related conditions these conditions; specifically stomach pain and cramps, persistent diarrhea, and flatulence.
It has not been tested in pregnant women nor in pregnant animals so pregnant women should not take it; it is expressed at low levels in breast milk, while no adverse effects have been reported in infants, breastfeeding women should not take this drug.
Adverse effects include hypersensitivity reactions and allergic reactions, immune system disorders, skin disorders including hives, edema and widespread rashes.
Additionally, the following adverse effects have been reported: heartburn, indigestion, constipation, loss of appetite, general malaise, dizziness, insomnia, headache, and decreased pulse rate.
Mechanism of action
Mebeverine is an anticholinergic but its mechanism of action is not known; it appears to work directly on smooth muscle within the gastrointestinal tract and may have an anesthetic effect, may affect calcium channels, and may affect muscarinic receptors.
It was first registered in 1965.
- "Colofac data sheet" (PDF). New Zealand Medicines and Medical Devices Safety Authority. 14 June 2017. Retrieved 21 July 2017.
- "Colofac Tablets 135mg - Summary of Product Characteristics (SPC)". UK Electronic Medicines Compendium. 26 August 2016. Retrieved 21 July 2017.
- Annaházi, A; Róka, R; Rosztóczy, A; Wittmann, T (28 May 2014). "Role of antispasmodics in the treatment of irritable bowel syndrome". World Journal of Gastroenterology. 20 (20): 6031–43. doi:10.3748/wjg.v20.i20.6031. PMC . PMID 24876726.
- Darvish-Damavandi, M; Nikfar, S; Abdollahi, M (7 February 2010). "A systematic review of efficacy and tolerability of mebeverine in irritable bowel syndrome". World Journal of Gastroenterology. 16 (5): 547–53. PMC . PMID 20128021.
- Sneader, Walter (2005). Drug Discovery: A History. John Wiley & Sons. p. 132. ISBN 9780471899792.
- Mebeverine page at druginfosys Page accessed Feb 1, 2015
- International page at drugs.com for Mebeverine Page accessed Feb 1, 2015