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Clinical data
Trade names Colofac, Duspamen, Duspatalin and others
AHFS/ International Drug Names
Routes of
By mouth
ATC code
Legal status
Legal status
CAS Number
PubChem CID
ECHA InfoCard 100.018.546
Chemical and physical data
Formula C25H35NO5
Molar mass 429.6 g/mol
3D model (JSmol)
Chirality Racemic mixture

Mebeverine is a drug used to alleviate some of the symptoms of irritable bowel syndrome. It works by relaxing the muscles in and around the gut.[1]

Mebeverine (Colofac) 135 mg, U.K.

Medical use[edit]

Mebeverine is used to alleviate some of the symptoms of irritable bowel syndrome (IBS) and related conditions these conditions; specifically stomach pain and cramps, persistent diarrhea, and flatulence.[2]

Data from controlled clinical trials have not found a difference from placebo in the alleviating stomach pain in people with IBS.[3][4]

It has not been tested in pregnant women nor in pregnant animals so pregnant women should not take it; it is expressed at low levels in breast milk, while no adverse effects have been reported in infants, breastfeeding women should not take this drug.[1]

Adverse effects[edit]

Adverse effects include hypersensitivity reactions and allergic reactions, immune system disorders, skin disorders including hives, edema and widespread rashes.[2]

Additionally, the following adverse effects have been reported: heartburn, indigestion, tiredness, diahorrea, constipation, loss of appetite, general malaise, dizziness, insomnia, headache, and decreased pulse rate.[1]

It does not have systemic anticholinergic side effects.[2]

Mechanism of action[edit]

Mebeverine is an anticholinergic but its mechanism of action is not known; it appears to work directly on smooth muscle within the gastrointestinal tract and may have an anesthetic effect, may affect calcium channels, and may affect muscarinic receptors.[2]

It is metabolized mostly by esterases, and almost completely. The metabolites are excreted in urine.[2]


It is a second generation papaverine analog, and was first synthesized around the same time as verapamil.[5]

It was first registered in 1965.[6]


Mebeverine is a generic drug and is available internationally under many brand names.[7]


  1. ^ a b c "Colofac data sheet" (PDF). New Zealand Medicines and Medical Devices Safety Authority. 14 June 2017. Retrieved 21 July 2017. 
  2. ^ a b c d e "Colofac Tablets 135mg - Summary of Product Characteristics (SPC)". UK Electronic Medicines Compendium. 26 August 2016. Retrieved 21 July 2017. 
  3. ^ Annaházi, A; Róka, R; Rosztóczy, A; Wittmann, T (28 May 2014). "Role of antispasmodics in the treatment of irritable bowel syndrome". World Journal of Gastroenterology. 20 (20): 6031–43. doi:10.3748/wjg.v20.i20.6031. PMC 4033443Freely accessible. PMID 24876726. 
  4. ^ Darvish-Damavandi, M; Nikfar, S; Abdollahi, M (7 February 2010). "A systematic review of efficacy and tolerability of mebeverine in irritable bowel syndrome". World Journal of Gastroenterology. 16 (5): 547–53. doi:10.3748/wjg.v16.i5.547. PMC 2816265Freely accessible. PMID 20128021. 
  5. ^ Sneader, Walter (2005). Drug Discovery: A History. John Wiley & Sons. p. 132. ISBN 9780471899792. 
  6. ^ Mebeverine page at druginfosys Page accessed Feb 1, 2015
  7. ^ International page at for Mebeverine Page accessed Feb 1, 2015