From Wikipedia, the free encyclopedia
Jump to: navigation, search
Butylscopolamine skeletal.svg
Systematic (IUPAC) name
Clinical data
Legal status
Routes of
Oral, rectal, intravenous
Pharmacokinetic data
Bioavailability <1%
Protein binding Low
Biological half-life 5 hours
Excretion Renal (50%)[citation needed] and fecal
CAS Registry Number 149-64-4 YesY
ATC code A03BB01
PubChem CID: 160883
DrugBank DB09300 YesY
Chemical data
Formula C21H30NO4+
Molecular mass 360.467 g/mol
 N (what is this?)  (verify)

Butylscopolamine — also known as scopolamine butylbromide, butylhyoscine, butylscopolaminebromide, and hyoscine butylbromide — is a peripherally acting antimuscarinic, anticholinergic agent.[1]

Butylscopolamine is used to treat pain and discomfort caused by abdominal cramps, menstrual cramps, or other spasmodic activity in the digestive system. It is also effective at preventing bladder spasms. It is not a pain medication in the normal sense, since it does not directly affect pain, but rather works to prevent painful cramps and spasms from occurring.

It is marketed under the trade name Buscopan.[2] It is on the WHO Model List of Essential Medicines, the most important medications needed in a basic health system.[3]

Medical uses[edit]

Butylscopolamine is used to treat crampy abdominal pain with some success.[4]

Hyoscine butylbromide is effective in significantly reducing the duration of the first stage of labour, and it is not associated with any obvious adverse outcomes in mother or neonate.[5]


It is a quaternary ammonium compound and a semisynthetic derivative of scopolamine. The attachment of the butyl-bromide moiety effectively prevents the movement of this drug across the blood–brain barrier, effectively minimising undesirable central nervous system side effects associated with scopolamine/hyoscine.


Butylscopolamine is not centrally active and has a low incidence of abuse.


  1. ^ Murakami, M.; Tomiyama, Y.; Hayakawa, K.; Akahane, M.; Ajisawa, Y.; Park, Y. C.; Ohnishi, N.; Sugiyama, T.; Kurita, T. (2000). "Effects of β-Adrenergic Stimulation on the Acutely Obstructed Ureter in Dogs" (pdf). Journal of Pharmacology and Experimental Therapeutics 292 (1): 67–75. PMID 10604932. 
  2. ^ http://www.buscopan.com.br/produtos/buscopan-composto.html
  3. ^ "WHO Model List of EssentialMedicines" (PDF). World Health Organization. October 2013. Retrieved 22 April 2014. 
  4. ^ Tytgat, G. N. (2007). "Hyoscine Butylbromide: A Review of its Use in the Treatment of Abdominal Cramping and Pain". Drugs 67 (9): 1343–1357. doi:10.2165/00003495-200767090-00007. PMID 17547475. 
  5. ^ Samuels, L. A.; Christie, L.; Roberts-Gittens, B.; Fletcher, H.; Frederick, J. (2007). "The effect of hyoscine butylbromide on the first stage of labour in term pregnancies". BJOG 114 (12): 1542–1546. doi:10.1111/j.1471-0528.2007.01497.x. PMID 17903230. 

External links[edit]