|Systematic (IUPAC) name|
|By mouth, rectal, intravenous|
|Biological half-life||5 hours|
|Excretion||Renal (50%) and fecal|
|ATC code||A03BB01 (WHO)|
|Molar mass||360.467 g/mol|
|(what is this?)|
Hyoscine butylbromide, also known as scopolamine butylbromide and sold under the brandname Buscopan, is a medication used to treat crampy abdominal pain, renal colic, and bladder spasms. It is also used to improve a death rattle at the end of life. Hyoscine butylbromide can be taken by mouth, injection into a muscle, or into a vein.
Side effects may include sleepiness, vision changes, triggering of glaucoma, and severe allergies. Sleepiness however, is uncommon. It is unclear if it is safe in pregnancy. It is an anticholinergic agent, which does not have much effect on the brain.
It is on the WHO Model List of Essential Medicines, the most important medications needed in a basic health system. It is not available in the United States. The wholesale cost in the developing world is 0.004 to 0.11 USD per pill as of 2014. It is manufactured from hyoscine which is naturally from the plant deadly nightshade.
Hyoscine butylbromide is effective in reducing the duration of the first stage of labour, and it is not associated with any obvious adverse outcomes in mother or neonate.
It is a quaternary ammonium compound and a semisynthetic derivative of scopolamine. The attachment of the butyl-bromide moiety effectively prevents the movement of this drug across the blood–brain barrier, effectively minimising undesirable central nervous system side effects associated with scopolamine/hyoscine.
Hyoscine butylbromide is not centrally active and has a low incidence of abuse.
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