Matuszak, drafted by the Houston Oilers of the NFL, was the first draft pick of 1973. In addition to his contract with the Oilers, he joined the Houston Texans of the World Football League, but played a total of seven plays before a restraining order that was served to him during a game that barred him from playing for two teams at the same time. Matuszak said he had no plans to play in that game but requested to play after seeing 25 or so men looking for him on the sidelines. He didn't know what was happening at the time and wanted to avoid confrontation. The Oilers, displeased that he tried joining the WFL, traded him to the Kansas City Chiefs, where he played until 1975. Then he found himself with the Raiders in 1976 after being released in pre-season by the Washington Redskins. He helped the Raiders win two Super Bowls (XI and XV) before retiring after spending the entire 1982 season on injured reserve.
His football career was often overshadowed by his even more famous (or infamous) partying and seemingly endless use of drugs. In his autobiography, he stated that he took many painkillers as well as other narcotics while playing professional football. Because of this, an article written for Sports Illustrated's website in January 2005 named him one of the top five all-time "bad boys" of the NFL. Although his performances made him one of the best Raider defenders of all time, his volatile actions contributed to him not being popular with teammates (Matt Millen told reporters on several occasions how he disliked Matuszak and found him to be phony) and not being one of Al Davis's favorite post-retirement players, and after an ugly incident where Matuszak violently assaulted assistant coach Terry Robiskie due to Matuszak hearing a false rumor that the team was going to trade away star tight end Todd Christensen, he was banned from ever setting foot in the Raiders' HQ again.