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Kuppamuthu Dharmalingam

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Kuppamuthu Dharmalingam
Born(1949-01-03)January 3, 1949
Pollachi, Tamil Nadu, India
NationalityIndian
Alma mater
Known forInduction of mutagenic DNA repair in Escherichia coli
Proteomics of eye diseases
Awards1992 Shanti Swarup Bhatnagar Prize
Scientific career
Fields
Institutions
Doctoral advisorJ. Jayaraman

Kuppamuthu Dharmalingam (born 1949) is an Indian proteomicist, geneticist, academic and the founder of Centre of Excellence in Bioinformatics at Madurai Kamaraj University. He is known for his contributions in the fields of eye disease proteomics and mutagenic DNA repair in Escherichia coli.[1] He is an elected fellow of the Indian Academy of Sciences[2] and the National Academy of Sciences, India.[3] The Council of Scientific and Industrial Research, the apex agency of the Government of India for scientific research, awarded him the Shanti Swarup Bhatnagar Prize for Science and Technology, one of the highest Indian science awards, in 1992, for his contributions to biological sciences.[4]

Biography

Born on 3 January 1949 in Pollachi, a border town in the South Indian state of Tamil Nadu, Kuppamuthu Dharmalingam did his schooling at Gandhi Kala Nilayam High School and secured his graduate and master's degrees in zoology from Thiagarajar College, Madurai before enrolling for PhD at Madurai Kamaraj University (MKU) under the guidance of J. Jayaraman, working on yeast mitochondrial membrane biogenesis.[5] After obtaining his doctoral degree, he did his post-doctoral research with Edward D. Goldberg at Tufts University School of Medicine on genetics of bacteriophages. Returning to India, he joined MKU[6] and spent his entire academic career there but had a short stint at University of Geneva in between. During his early researches on Escherichia coli, a gram-negative bacterium, he discovered the induction of mutagenic DNA repair during restriction of nonglucosylated T4 DNA and the alleviation of restriction by SOS functions.[7] Subsequently, he studied the pathogenesis of Mycobacterium leprae using proteomics tools and discovered the single nucleotide polymorphism in the unique small alpha crystalline like heat shock protein in the gram-positive bacterium.[8] His researches have been documented in over 200 articles; ResearchGate, an online repository of scientific papers, has listed 48 of them.[9]

It was during his tenure at the MKU, the Centre of Excellence in Bioinformatics was established at the university in 1986.[5] He is a life member of the Proteomics Society, India (PSI),[10] editor of its newsletter,[11] a former member of its executive council and was the convener of the workshop, Clinical Proteomics: Methods and Applications, conducted by PSI in October 2014.[12] He is a Distinguished Research Professor of the Department of Biotechnology and an elected fellow of the Indian Academy of Sciences[2] and the National Academy of Sciences, India.[3] The Council of Scientific and Industrial Research awarded him the Shanti Swarup Bhatnagar Prize, one of the highest Indian science awards, in 1992.[4]

Post retirement, Dharmalingam has been working since 2013 as a director of Aravind Medical Research Foundation, a Tamil Nadu-based research centre, ophthalmic hospital chain and a World Health Organization collaborating centre for the prevention of blindness.[13]

See also

References

  1. ^ "Brief Profile of the Awardee". Shanti Swarup Bhatnagar Prize. 2016. Retrieved October 5, 2016.
  2. ^ a b "Fellow profile - Dharmalingam". Indian Academy of Sciences. 2016. Retrieved October 6, 2016.
  3. ^ a b "NASI fellows". National Academy of Sciences, India. 2016. Archived from the original on July 17, 2015. Retrieved October 6, 2016. {{cite web}}: Unknown parameter |deadurl= ignored (|url-status= suggested) (help)
  4. ^ a b "View Bhatnagar Awardees". Shanti Swarup Bhatnagar Prize. 2016. Retrieved October 5, 2016.
  5. ^ a b Subhoshree Ghose; Swati Varshney (2015). "Rendezvouz with a Pioneer: Professor Kuppamuthu Dharmalingam" (PDF). Journal of Proteins and Proteomics. 6 (2): 147–151.
  6. ^ Michael J. Murphy (24 March 2011). Molecular Diagnostics in Dermatology and Dermatopathology. Springer Science & Business Media. pp. 347–. ISBN 978-1-60761-171-4.
  7. ^ "Handbook of Shanti Swarup Bhatnagar Prize Winners" (PDF). Council of Scientific and Industrial Research. 1999. p. 30. Retrieved October 5, 2016.
  8. ^ Rehna EA1, Singh SK, Dharmalingam K. (2008). "Functional insights by comparison of modeled structures of 18kDa small heat shock protein and its mutant in Mycobacterium leprae". Bioinformation. 3 (5): 230–4. doi:10.6026/97320630003230. PMC 2646194. PMID 19255639.{{cite journal}}: CS1 maint: multiple names: authors list (link) CS1 maint: numeric names: authors list (link)
  9. ^ "Kuppamuthu Dharmalingam on ResearchGate". ResearchGate. 2016. Retrieved October 6, 2016.
  10. ^ "Life members". Proteomics Society, India. 2016. Retrieved October 6, 2016.
  11. ^ "PSII News Letter" (PDF). Proteomics Society, India. 2016. Retrieved October 6, 2016.
  12. ^ "Clinical Proteomics: Methods and Applications" (PDF). PSi Newsletter. 2016. Retrieved October 6, 2016.
  13. ^ "Director & DBT Distinguished Biotechnology Research". Aravind Eye Care System. 2016. Retrieved October 6, 2016.
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