Latent-transforming growth factor beta-binding protein 1 is a protein that in humans is encoded by the LTBP1gene.[5][6][7]
The protein encoded by this gene belongs to the family of latent TGF-beta binding proteins (LTBPs). The secretion and activation of TGF-betas is regulated by their association with latency-associated proteins and with latent TGF-beta binding proteins. The product of this gene targets latent complexes of transforming growth factor beta to the extracellular matrix, where the latent cytokine is subsequently activated by several different mechanisms. Alternatively spliced transcript variants encoding different isoforms have been identified.[7]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Kanzaki T, Olofsson A, Moren A, Wernstedt C, Hellman U, Miyazono K, Claesson-Welsh L, Heldin CH (July 1990). "TGF-beta 1 binding protein: a component of the large latent complex of TGF-beta 1 with multiple repeat sequences". Cell. 61 (6): 1051–1061. doi:10.1016/0092-8674(90)90069-Q. PMID2350783. S2CID54376541.
Keski-Oja J, Koli K, von Melchner H (2005). "TGF-beta activation by traction?". Trends Cell Biol. 14 (12): 657–659. doi:10.1016/j.tcb.2004.10.003. PMID15564041.
Stenman G, Sahlin P, Olofsson A, et al. (1994). "Assignment of the gene encoding the latent TGF-beta 1-binding protein (LTBP1) to human chromosome 2, region p12→q22". Cytogenet. Cell Genet. 66 (2): 117–119. doi:10.1159/000133680. PMID8287682.
Karonen T, Jeskanen L, Keski-Oja J (1997). "Transforming growth factor beta 1 and its latent form binding protein-1 associate with elastic fibres in human dermis: accumulation in actinic damage and absence in anetoderma". Br. J. Dermatol. 137 (1): 51–58. doi:10.1111/j.1365-2133.1997.tb03700.x. PMID9274625.
Gui Y, Murphy LJ (2004). "Interaction of insulin-like growth factor binding protein-3 with latent transforming growth factor-beta binding protein-1". Mol. Cell. Biochem. 250 (1–2): 189–195. doi:10.1023/A:1024990409102. PMID12962157. S2CID6372795.
Weikkolainen K, Keski-Oja J, Koli K (2004). "Expression of latent TGF-beta binding protein LTBP-1 is hormonally regulated in normal and transformed human lung fibroblasts". Growth Factors. 21 (2): 51–60. doi:10.1080/08977198310001598778. PMID14626352. S2CID42812652.