Etofibrate

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Etofibrate
Etofibrate.svg
Space-filling model of the etofibrate molecule
Clinical data
AHFS/Drugs.com International Drug Names
ATC code C10AB09 (WHO)
Pharmacokinetic data
Metabolism Hydrolyzed to clofibric acid and niacin
Identifiers
CAS Number 31637-97-5 YesY
PubChem (CID) 65777
DrugBank DB08983 YesY
ChemSpider 59197 YesY
UNII 23TF67G79M YesY
KEGG D07187 YesY
ChEMBL CHEMBL358150 YesY
ECHA InfoCard 100.046.115
Chemical and physical data
Formula C18H18ClNO5
Molar mass 363.792 g/mol
3D model (Jmol) Interactive image
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Etofibrate is a fibrate. It is a combination of clofibrate and niacin, linked together by an ester bond. In the body, clofibrate and niacin separate and are released gradually, in a manner similar to controlled-release formulations.[1]

References[edit]

  1. ^ Sposito AC, Mansur AP, Maranhão RC, Rodrigues-Sobrinho CR, Coelho OR, Ramires JA (2001). "Etofibrate but not controlled-release niacin decreases LDL cholesterol and lipoprotein (a) in type IIb dyslipidemic subjects". Braz J Med Biol Res. 34 (2): 177–82. doi:10.1590/S0100-879X2001000200004. PMID 11175492.  Free full text