Lysine carboxypeptidase

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Lysine carboxypeptidase
Identifiers
EC number 3.4.17.3
CAS number 9013-89-2
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Lysine carboxypeptidase (EC 3.4.17.3, carboxypeptidase N, arginine carboxypeptidase, kininase I, anaphylatoxin inactivator, plasma carboxypeptidase B, creatine kinase conversion factor, bradykinase, kininase Ia, hippuryllysine hydrolase, bradykinin-decomposing enzyme, protaminase, CPase N, creatinine kinase convertase, peptidyl-L-lysine(-L-arginine) hydrolase, CPN) is an enzyme.[1][2][3] This enzyme catalyses the following chemical reaction

Release of a C-terminal basic amino acid, preferentially lysine

This is a zinc enzyme found in plasma. It inactivates bradykinin and anaphylatoxins.

References[edit]

  1. ^ Plummer TH, Erdös EG (1981). "Human plasma carboxypeptidase N". Methods in Enzymology. 80 Pt C: 442–9. doi:10.1016/s0076-6879(81)80038-9. PMID 7341915. 
  2. ^ Levin Y, Skidgel RA, Erdös EG (August 1982). "Isolation and characterization of the subunits of human plasma carboxypeptidase N (kininase i)". Proceedings of the National Academy of Sciences of the United States of America. 79 (15): 4618–22. doi:10.1073/pnas.79.15.4618. PMC 346726Freely accessible. PMID 6750606. 
  3. ^ Skidgel RA (August 1988). "Basic carboxypeptidases: regulators of peptide hormone activity". Trends in Pharmacological Sciences. 9 (8): 299–304. doi:10.1016/0165-6147(88)90015-6. PMID 3074547. 

External links[edit]