Mark M. Davis
|Mark M. Davis|
Mark Davis at the Royal Society admissions day in London in 2016
|Born||27 November 1952|
|Thesis||Programmed DNA rearrangements during differentiation : immunoglobulin class switching (1981)|
|Doctoral advisor||Leroy E. Hood|
Davis is well known for identifying the first T-cell receptor genes, which are responsible for T lymphocytes ability to “see” foreign entities, solving a major mystery in immunology at that time. He and his research group have made many subsequent discoveries about this type of molecule, subsequently, specifically concerning its biochemical properties and other characteristics, including the demonstration that T cells are able to detect and respond to even a single molecule of their ligand-fragments of antigens bound to Major Histocompatibility Complex cell surface molecules. He also developed a novel way of labeling specific T lymphocytes according to the molecules that they recognize, and this procedure is now an important method in many clinical and basic studies of T cell activity, from new vaccines against cancer to identifying “rogue” T cells in autoimmunity. In recent years his has increasingly focused on understanding the human immune system, from developing broad systems biology approaches to inventing new methods to help unravel the complexities of T cell responses to cancer, autoimmunity and infectious diseases.
Awards and honors
Davis has won numerous awards including:
- Passano Young Scientist Award together with James Edward Rothman in 1985
- Eli Lilly and Company Research Award in 1986
- Howard Taylor Ricketts Award in 1987
- Gairdner Foundation International Award in 1989
- Elected a member of the National Academy of Sciences in 1993
- King Faisal International Prize in 1995
- Alfred P. Sloan, Jr. Prize together with Tak W. Mak in 1996
- Membership in the American Academy of Arts and Sciences in 2000
- William B. Coley Award in 2000
- Paul Ehrlich and Ludwig Darmstaedter Prize together with Tak Wah Mak in 2004
- Elected a Foreign Member of the Royal Society (ForMemRS) in 2016
- Anon (2016). "Professor Mark Davis ForMemRS". London: Royal Society. Archived from the original on 2016-04-29. One or more of the preceding sentences incorporates text from the royalsociety.org website where:
“All text published under the heading 'Biography' on Fellow profile pages is available under Creative Commons Attribution 4.0 International License.” --"Royal Society Terms, conditions and policies". Archived from the original on September 25, 2015. Retrieved 2016-03-09.
- "Mark M. Davis: Burt and Marion Avery Family Professor". Stanford: stanford.edu. Archived from the original on 2016-03-25.
- Mark M. Davis publications indexed by Google Scholar
- Davis, Mark Morris (1981). Programmed DNA rearrangements during differentiation : immunoglobulin class switching (PhD thesis). California Institute of Technology. OCLC 436997013.
- Altman, J. D.; Moss, P. A. H.; Goulder, P. J. R.; Barouch, D. H.; McHeyzer-Williams, M. G.; Bell, J. I.; McMichael, A. J.; Davis, M. M. (1996). "Phenotypic Analysis of Antigen-Specific T Lymphocytes". Science. 274 (5284): 94–96. doi:10.1126/science.274.5284.94. PMID 8810254.
- Davis, Mark M.; Bjorkman, Pamela J. (1988). "T-cell antigen receptor genes and T-cell recognition". Nature. 334 (6181): 395–402. doi:10.1038/334395a0.
- Grakoui, A. (1999). "The Immunological Synapse: A Molecular Machine Controlling T Cell Activation". Science. 285 (5425): 221–227. doi:10.1126/science.285.5425.221. ISSN 0036-8075. PMID 10398592.