Mucin 2, oligomeric mucus gel-forming, also known as MUC2, is a protein that in humans is encoded by the MUC2 gene. 
Function [ edit ]
This gene encodes a member of the
mucin protein family. The protein encoded by this gene, also called mucin 2, is secreted onto mucosal surfaces.
Mucin 2 is particularly prominent in the gut where it is secreted from
goblet cells in the epithelial lining into the lumen of the large intestine. There, mucin 2, along with small amounts of related-mucin proteins, polymerizes into a gel of which 80% by weight is oligosaccharide side-chains that are added as post-translational modifications to the mucin proteins. This gel provides an insoluble mucous barrier that serves to protect the intestinal epithelium.
Genetics [ edit ]
The mucin 2 protein features a central domain containing tandem repeats rich in
threonine and proline that varies between 50 and 115 copies in different individuals. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.
References [ edit ]
^ a b c
ENSG00000278466, ENSG00000198788 GRCh38: Ensembl release 89: ENSG00000284971, ENSG00000278466, ENSG00000198788 - Ensembl, May 2017
"Human PubMed Reference:".
"Mouse PubMed Reference:".
^ a b
Allen A, Hutton DA, Pearson JP (July 1998). "The MUC2 gene product: a human intestinal mucin". Int. J. Biochem. Cell Biol. 30 (7): 797–801. doi: 10.1016/S1357-2725(98)00028-4. PMID 9722984.
Rousseau K, Byrne C, Kim YS, Gum JR, Swallow DM, Toribara NW (May 2004). "The complete genomic organization of the human MUC6 and MUC2 mucin genes". Genomics. 83 (5): 936–9. doi: 10.1016/j.ygeno.2003.11.003. PMID 15081123.
"Entrez Gene: MUC2 mucin 2, oligomeric mucus/gel-forming".