Noni juice

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Noni fruit and juice. Commercial noni juice excludes the pulp pictured here.

Noni juice is derived from the fruit of the Morinda citrifolia tree indigenous to Southeast Asia and Australasia.

Noni juice has been promoted as a cure for a number of human diseases. However, there is no evidence to support these claims.[1]


Sold in capsule form, pulp powder was the first M. citrifolia product brought to the commercial market in Hawaii by Herbert Moniz of Herb's Herbs in 1992 after patenting a unique M. citrifolia dehydrating method.(US 5288491 )

Regulatory warnings and safety testing[edit]

In August 2004, the US Food and Drug Administration issued a Warning Letter to Flora, Inc. for violating section 201(g)(1) of the Federal Food, Drug, and Cosmetic Act (the Act) [21 U.S.C. § 321(g)(1)]. Flora made twelve unfounded health claims about the purported benefits of noni juice as a medical product, in effect causing the juice to be evaluated as a drug. Under the Act, this necessitates all safety and clinical trial evidence for the juice providing such effects in humans.[2]

The FDA letter also cited 1) absent scientific evidence for health benefits of the noni phytochemicals scopoletin and damnacanthal, neither of which has been confirmed with biological activity in humans, and 2) lack of scientific foundation for health claims made by two proponents of noni juice, Dr. Isabella Abbot and Dr. Ralph Heinicke.[2]

Two other FDA letters have been issued for the same types of violations.[3][4]

In the European Union, after safety testing on one particular brand of noni juice (Tahitian Noni), approval was granted in 2002 as a novel food by the European Commission for Health and Consumer Protection Directorate-General.[5] In their report, the European Commission's Scientific Committee made no endorsement of health claims.


In 2005, two scientific publications as clinical case reports described incidents of acute hepatitis caused by ingesting noni juice. Research has pointed to anthraquinones found in noni roots, leaves and fruit[6][7] as potentially toxic to the liver and other organs.[8] These case reports were reviewed in 2006 by the European Food Safety Authority (EFSA), concluding that no causal link could be established.[9] One government report, however, advises against consumption of noni products if one has a history of liver disorders.[10]

The potential for toxicity caused by noni juices remains under surveillance by EFSA, individual food safety authorities in France,[11] Finland[12] and Ireland,[13] and medical investigators in Germany.[14] One review of toxicity tests and safety issues surrounding noni juice was published, finding that there were no adverse effects from consumption of the juice,[15] but another review indicates that safety concerns about consuming noni products have not been adequately addressed in scientific studies.[10]

The Physicians Desk Reference (PDR) for Non-Prescription Drugs and Dietary Supplements lists only one particular commercial brand of noni juice, with no side-effects mentioned.[16] Consumers of noni juice are advised to carefully check labels for warnings which may say "Not safe for pregnant women" or "Keep out of reach of children."

Noni plants and juice have been promoted by practitioners of alternative medicine as a cure for a number of human maladies including HIV, heart disease and cancer. However, noni products may contain high amounts of potassium, leading to one advisory that people on potassium-restricted diets because of kidney problems should avoid using noni.[10] Also, according to the American Cancer Society "there is no reliable clinical evidence that noni juice is effective in preventing or treating cancer or any other disease in humans".[1]

See also[edit]


  1. ^ a b "Noni Plant". American Cancer Society. 1 November 2008. Retrieved 20 September 2013.
  2. ^ a b Breen, Charles M. (August 26, 2004). "Warning letter from the FDA to Flora, Inc" (PDF).
  3. ^ "Noni Tahitian Plus" (PDF). 2009-04-30. Retrieved 2011-07-09.
  4. ^ "Cyber Warning Letter". 2009-04-30. Retrieved 2011-07-09.
  5. ^ European Commission Health and Consumer Protection Directorate-General (December 11, 2002). "Opinion of the Scientific Committee on Food on Tahitian Noni juice" (PDF).
  6. ^ Pawlus AD, Su BN, Keller WJ, Kinghorn AD (December 2005). "An anthraquinone with potent quinone reductase-inducing activity and other constituents of the fruits of Morinda citrifolia (noni)". J. Nat. Prod. 68 (12): 1720–2. doi:10.1021/np050383k. PMID 16378361.
  7. ^ Millonig G, Stadlmann S, Vogel W (April 2005). "Herbal hepatotoxicity: acute hepatitis caused by a Noni preparation (Morinda citrifolia)". European Journal of Gastroenterology & Hepatology. 17 (4): 445–7. doi:10.1097/00042737-200504000-00009. PMID 15756098.
  8. ^ Dodd, D. E.; Layko, D. K.; Cantwell, K. E.; Willson, G. A.; Thomas, R. S. (2013). "Subchronic Toxicity Evaluation of Anthraquinone in Fischer 344 Rats". International Journal of Toxicology. 32 (5): 358–367. doi:10.1177/1091581813501701. PMID 23966314.
  9. ^ "EFSA re-assesses safety of noni juice". European Food Safety Authority. 6 September 2006. Retrieved 24 September 2014.
  10. ^ a b c "Noni". National Center for Complementary and Integrative Health, US National Institutes of Health. April 2012. Retrieved 24 September 2014.
  11. ^ "France warns consumers off noni juice". Retrieved 2011-07-09.
  12. ^ "Press release: National Food Agency warns about illegal noni products - Finnish Food Safety Authority Evira". Retrieved 2011-07-09.
  13. ^ FSAI - Food Safety Authority Warns of Unsubstantiated Claims on Noni Juice
  14. ^ Yüce B, Gulberg V, Diebold J, Gerbes AL (February 2006). "Hepatitis induced by Noni juice from Morinda citrifolia: a rare cause of hepatotoxicity or the tip of the iceberg?". Digestion. 73 (2–3): 167–70. doi:10.1159/000094524. PMID 16837801.
  15. ^ West, B. J.; Jensen, C. J.; Westendorf, J.; White, L. D. (2006). "A Safety Review of Noni Fruit Juice". Journal of Food Science. 71 (8): R100. doi:10.1111/j.1750-3841.2006.00164.x.
  16. ^ Thomson Healthcare (Micromedex) (November 25, 2006). "Tahitian Noni Juice".

Further reading[edit]