From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Ghk.
Gamma-glutamyl hydrolase is an enzyme [5] [6] [7] [8] that catalyses the following chemical reaction :
Hydrolysis of a gamma-glutamyl bond
This lysosomal or secreted, thiol -dependent peptidase , most active at acidic pH .
In humans, gamma-glutamyl hydrolase is encoded by the GGH gene .[7] [9] [10] This gene catalyzes the hydrolysis of folylpoly-gamma-glutamates and antifolylpoly-gamma-glutamates by the removal of gamma-linked polyglutamates and glutamate.[10]
Nomenclature [ edit ]
Gamma-glutamyl hydrolase is also known as conjugase, folate conjugase, lysosomal gamma-glutamyl carboxypeptidase, gamma-Glu-X carboxypeptidase, pteroyl-poly-gamma-glutamate hydrolase, carboxypeptidase G, folic acid conjugase, poly(gamma-glutamic acid) endohydrolase, polyglutamate hydrolase, poly(glutamic acid) hydrolase II, pteroylpoly-gamma-glutamyl hydrolase.
Interactive pathway map [ edit ]
Click on genes, proteins and metabolites below to link to respective articles. [§ 1]
[[File:
|alt=Fluorouracil (5-FU) Activity
edit ]]
Fluorouracil (5-FU) Activity
edit
References [ edit ]
^ a b c GRCh38: Ensembl release 89: ENSG00000137563 – Ensembl , May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000073987 – Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Wang Y, Nimec Z, Ryan TJ, Dias JA, Galivan J (August 1993). "The properties of the secreted gamma-glutamyl hydrolases from H35 hepatoma cells". Biochim. Biophys. Acta . 1164 (3): 227–35. doi :10.1016/0167-4838(93)90253-n . PMID 8343522 .
^ Yao R, Rhee MS, Galivan J (September 1995). "Effects of gamma-glutamyl hydrolase on folyl and antifolylpolyglutamates in cultured H35 hepatoma cells". Mol. Pharmacol . 48 (3): 505–11. PMID 7565632 .
^ a b Yao R, Schneider E, Ryan TJ, Galivan J (September 1996). "Human gamma-glutamyl hydrolase: cloning and characterization of the enzyme expressed in vitro" . Proc. Natl. Acad. Sci. U.S.A . 93 (19): 10134–8. Bibcode :1996PNAS...9310134Y . doi :10.1073/pnas.93.19.10134 . PMC 38349 . PMID 8816764 .
^ Yao R, Nimec Z, Ryan TJ, Galivan J (April 1996). "Identification, cloning, and sequencing of a cDNA coding for rat gamma-glutamyl hydrolase" . J. Biol. Chem . 271 (15): 8525–8. doi :10.1074/jbc.271.15.8525 . PMID 8621474 .
^ Yin D, Chave KJ, Macaluso CR, Galivan J, Yao R (Dec 1999). "Structural organization of the human gamma-glutamyl hydrolase gene". Gene . 238 (2): 463–70. doi :10.1016/S0378-1119(99)00362-5 . PMID 10570974 .
^ a b "Entrez Gene: GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)" . Archived from the original on 2022-12-12. Retrieved 2017-08-31 .
Further reading [ edit ]
Galivan J, Ryan T, Rhee M, et al. (1999). "Glutamyl hydrolase: properties and pharmacologic impact". Semin. Oncol . 26 (2 Suppl 6): 33–7. PMID 10598552 .
O'Connor BM, Rotundo RF, Nimec Z, et al. (1991). "Secretion of gamma-glutamyl hydrolase in vitro". Cancer Res . 51 (15): 3874–81. PMID 1713122 .
Chandler CJ, Wang TT, Halsted CH (1986). "Pteroylpolyglutamate hydrolase from human jejunal brush borders. Purification and characterization" . J. Biol. Chem . 261 (2): 928–33. doi :10.1016/S0021-9258(17)36185-9 . PMID 2867095 .
Wang TT, Chandler CJ, Halsted CH (1986). "Intracellular pteroylpolyglutamate hydrolase from human jejunal mucosa. Isolation and characterization" . J. Biol. Chem . 261 (29): 13551–5. doi :10.1016/S0021-9258(18)67054-1 . PMID 3759978 .
Yao R, Nimec Z, Ryan TJ, Galivan J (1996). "Identification, cloning, and sequencing of a cDNA coding for rat gamma-glutamyl hydrolase" . J. Biol. Chem . 271 (15): 8525–8. doi :10.1074/jbc.271.15.8525 . PMID 8621474 .
Rhee MS, Lindau-Shepard B, Chave KJ, et al. (1998). "Characterization of human cellular gamma-glutamyl hydrolase". Mol. Pharmacol . 53 (6): 1040–6. PMID 9614206 .
Li H, Ryan TJ, Chave KJ, Van Roey P (2002). "Three-dimensional structure of human gamma -glutamyl hydrolase. A class I glatamine amidotransferase adapted for a complex substrate" . J. Biol. Chem . 277 (27): 24522–9. doi :10.1074/jbc.M202020200 . PMID 11953431 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 . PMC 139241 . PMID 12477932 .
Basrur V, Yang F, Kushimoto T, et al. (2003). "Proteomic analysis of early melanosomes: identification of novel melanosomal proteins". J. Proteome Res . 2 (1): 69–79. doi :10.1021/pr025562r . PMID 12643545 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 . PMID 15489334 .
He P, Varticovski L, Bowman ED, et al. (2004). "Identification of carboxypeptidase E and gamma-glutamyl hydrolase as biomarkers for pulmonary neuroendocrine tumors by cDNA microarray" . Hum. Pathol . 35 (10): 1196–209. doi :10.1016/j.humpath.2004.06.014 . PMID 15492986 . Archived from the original on 2022-10-15. Retrieved 2020-09-10 .
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173–8. Bibcode :2005Natur.437.1173R . doi :10.1038/nature04209 . PMID 16189514 . S2CID 4427026 .
Eisele LE, Chave KJ, Lehning AC, Ryan TJ (2006). "Characterization of Human gamma-glutamyl hydrolase in solution demonstrates that the enzyme is a non-dissociating homodimer". Biochim. Biophys. Acta . 1764 (9): 1479–86. doi :10.1016/j.bbapap.2006.06.008 . PMID 16945597 .
Chi A, Valencia JC, Hu ZZ, et al. (2007). "Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes". J. Proteome Res . 5 (11): 3135–44. doi :10.1021/pr060363j . PMID 17081065 .
Hayashi H, Fujimaki C, Inoue K, et al. (2007). "Genetic polymorphism of C452T (T127I) in human gamma-glutamyl hydrolase in a Japanese population" . Biol. Pharm. Bull . 30 (4): 839–41. doi :10.1248/bpb.30.839 . PMID 17409534 .
External links [ edit ]
Activity Regulation Classification Kinetics Types