Pyrin domain

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PAAD/DAPIN/Pyrin domain
PDB 1pn5 EBI.jpg
Pfam clanCL0041

A pyrin domain is a protein domain and a subclass of protein motif known as the death fold; it allows a pyrin domain containing protein to interact with other proteins that contain a pyrin domain. It is also known as a PYD or PAAD/DAPIN domain, and is distantly evolutionarily related to the Death domain family of protein domains.[1][2][3] Proteins containing a pyrin domain are frequently involved in biological processes called inflammation and apoptosis.[4][5] Proteins that possess a pyrin domain include intracellular microbial sensors called NOD-like receptors, and proteins associated with their function, such as PYCARD and certain fish caspases.


  1. ^ Fairbrother WJ, Gordon NC, Humke EW, et al. (September 2001). "The PYRIN domain: a member of the death domain-fold superfamily". Protein Sci. 10 (9): 1911–8. doi:10.1110/ps.13801. PMC 2253208. PMID 11514682.
  2. ^ Staub E, Dahl E, Rosenthal A (February 2001). "The DAPIN family: a novel domain links apoptotic and interferon response proteins". Trends Biochem. Sci. 26 (2): 83–5. doi:10.1016/s0968-0004(00)01717-5. PMID 11166557.
  3. ^ Pawłowski K, Pio F, Chu Z, Reed JC, Godzik A (February 2001). "PAAD - a new protein domain associated with apoptosis, cancer and autoimmune diseases". Trends Biochem. Sci. 26 (2): 85–7. doi:10.1016/s0968-0004(00)01729-1. PMID 11166558.
  4. ^ Bertin J, DiStefano PS (December 2000). "The PYRIN domain: a novel motif found in apoptosis and inflammation proteins". Cell Death Differ. 7 (12): 1273–4. doi:10.1038/sj.cdd.4400774. PMID 11270363.
  5. ^ Gumucio DL, Diaz A, Schaner P, et al. (2002). "Fire and ICE: the role of pyrin domain-containing proteins in inflammation and apoptosis". Clin. Exp. Rheumatol. 20 (4 Suppl 26): S45–53. PMID 12371636.