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SNX13

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SNX13
Identifiers
AliasesSNX13, RGS-PX1, sorting nexin 13
External IDsOMIM: 606589; MGI: 2661416; HomoloGene: 41011; GeneCards: SNX13; OMA:SNX13 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_015132

NM_001014973

RefSeq (protein)

NP_001014973

Location (UCSC)n/aChr 12: 35.1 – 35.2 Mb
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Sorting nexin-13 is a protein that in humans is encoded by the SNX13 gene.[4][5][6]

Function

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This gene encodes a PHOX domain- and RGS domain-containing protein that belongs to the sorting nexin (SNX) family and the regulator of G protein signaling (RGS) family. The PHOX domain is a phosphoinositide binding domain, and the SNX family members are involved in intracellular trafficking. The RGS family members are regulatory molecules that act as GTPase activating proteins for G alpha subunits of heterotrimeric G proteins. The RGS domain of this protein interacts with G alpha(s), accelerates its GTP hydrolysis, and attenuates G alpha(s)-mediated signaling. Overexpression of this protein delays lysosomal degradation of the epidermal growth factor receptor. Because of its bifunctional role, this protein may link heterotrimeric G protein signaling and vesicular trafficking.[6]

References

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  1. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020590Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ Teasdale RD, Loci D, Houghton F, Karlsson L, Gleeson PA (August 2001). "A large family of endosome-localized proteins related to sorting nexin 1". The Biochemical Journal. 358 (Pt 1): 7–16. doi:10.1042/0264-6021:3580007. PMC 1222026. PMID 11485546.
  5. ^ Zheng B, Ma YC, Ostrom RS, Lavoie C, Gill GN, Insel PA, Huang XY, Farquhar MG (November 2001). "RGS-PX1, a GAP for GalphaS and sorting nexin in vesicular trafficking". Science. 294 (5548): 1939–42. Bibcode:2001Sci...294.1939Z. doi:10.1126/science.1064757. PMID 11729322. S2CID 85169394.
  6. ^ a b "Entrez Gene: SNX13 sorting nexin 13".

Further reading

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