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Protein-coding gene in the species Homo sapiens
Serpin B4 is a protein that in humans is encoded by the SERPINB4 gene .[5] [6] [7]
See also [ edit ] References [ edit ]
^ a b c GRCh38: Ensembl release 89: ENSG00000206073 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000044594 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Schneider SS, Schick C, Fish KE, Miller E, Pena JC, Treter SD, Hui SM, Silverman GA (May 1995). "A serine proteinase inhibitor locus at 18q21.3 contains a tandem duplication of the human squamous cell carcinoma antigen gene" . Proc Natl Acad Sci U S A . 92 (8): 3147–51. Bibcode :1995PNAS...92.3147S . doi :10.1073/pnas.92.8.3147 PMC 42122 PMID 7724531 . ^ Sakata Y, Arima K, Takai T, Sakurai W, Masumoto K, Yuyama N, Suminami Y, Kishi F, Yamashita T, Kato T, Ogawa H, Fujimoto K, Matsuo Y, Sugita Y, Izuhara K (Feb 2004). "The squamous cell carcinoma antigen 2 inhibits the cysteine proteinase activity of a major mite allergen, Der p 1" . J Biol Chem . 279 (7): 5081–7. doi :10.1074/jbc.M311585200 PMID 14630915 . ^ "Entrez Gene: SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4" .
Further reading [ edit ]
Barnes RC, Worrall DM (1995). "Identification of a novel human serpin gene; cloning sequencing and expression of leupin" . FEBS Letters . 373 (1): 61–5. doi :10.1016/0014-5793(95)01015-7 PMID 7589435 . S2CID 26092255 . Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery" . Genome Res . 6 (9): 791–806. doi :10.1101/gr.6.9.791 PMID 8889548 . Bartuski AJ, Kamachi Y, Schick C, et al. (1999). "A murine ortholog of the human serpin SCCA2 maps to chromosome 1 and inhibits chymotrypsin-like serine proteinases". Genomics . 54 (2): 297–306. doi :10.1006/geno.1998.5586 . PMID 9828132 . Sakaguchi Y, Kishi F, Murakami A, et al. (1999). "Structural analysis of human SCC antigen 2 promoter". Biochim. Biophys. Acta . 1444 (1): 111–6. doi :10.1016/s0167-4781(98)00259-0 . PMID 9931463 . Cataltepe S, Gornstein ER, Schick C, et al. (2000). "Co-expression of the squamous cell carcinoma antigens 1 and 2 in normal adult human tissues and squamous cell carcinomas" . J. Histochem. Cytochem . 48 (1): 113–22. doi :10.1177/002215540004800112 PMID 10653592 . Luke C, Schick C, Tsu C, et al. (2000). "Simple modifications of the serpin reactive site loop convert SCCA2 into a cysteine proteinase inhibitor: a critical role for the P3' proline in facilitating RSL cleavage". Biochemistry . 39 (24): 7081–91. doi :10.1021/bi000050g . PMID 10852705 . Uemura Y, Pak SC, Luke C, et al. (2000). "Circulating serpin tumor markers SCCA1 and SCCA2 are not actively secreted but reside in the cytosol of squamous carcinoma cells" . Int. J. Cancer . 89 (4): 368–77. doi :10.1002/1097-0215(20000720)89:4<368::AID-IJC9>3.0.CO;2-6 PMID 10956412 . S2CID 23697095 . Hamada K, Shinomiya H, Asano Y, et al. (2001). "Molecular cloning of human squamous cell carcinoma antigen 1 gene and characterization of its promoter". Biochim. Biophys. Acta . 1518 (1–2): 124–31. doi :10.1016/s0167-4781(01)00174-9 . PMID 11267667 . Takeda A, Kajiya A, Iwasawa A, et al. (2003). "Aberrant expression of serpin squamous cell carcinoma antigen 2 in human tumor tissues and cell lines: evidence of protection from tumor necrosis factor-mediated apoptosis". Biol. Chem . 383 (7–8): 1231–6. doi :10.1515/BC.2002.136 . PMID 12437110 . S2CID 23972588 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Gariboldi M, Peissel B, Fabbri A, et al. (2003). "SCCA2-like serpins mediate genetic predisposition to skin tumors". Cancer Res . 63 (8): 1871–5. PMID 12702576 . Pontisso P, Calabrese F, Benvegnù L, et al. (2004). "Overexpression of squamous cell carcinoma antigen variants in hepatocellular carcinoma" . Br. J. Cancer . 90 (4): 833–7. doi :10.1038/sj.bjc.6601543 . PMC 2410161 PMID 14970861 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Ray R, Choi M, Zhang Z, et al. (2005). "Uteroglobin suppresses SCCA gene expression associated with allergic asthma" . J. Biol. Chem . 280 (11): 9761–4. doi :10.1074/jbc.C400581200 PMID 15677460 . Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173–8. Bibcode :2005Natur.437.1173R . doi :10.1038/nature04209 . PMID 16189514 . S2CID 4427026 . Sueoka K, Nawata S, Nakagawa T, et al. (2005). "Tumor-associated serpin, squamous cell carcinoma antigen stimulates matrix metalloproteinase-9 production in cervical squamous cell carcinoma cell lines". Int. J. Oncol . 27 (5): 1345–53. doi :10.3892/ijo.27.5.1345 . PMID 16211231 . Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes" . Genome Research . 16 (1): 55–65. doi :10.1101/gr.4039406 . PMC 1356129 PMID 16344560 . Katagiri C, Nakanishi J, Kadoya K, Hibino T (2006). "Serpin squamous cell carcinoma antigen inhibits UV-induced apoptosis via suppression of c-JUN NH2-terminal kinase" . J. Cell Biol . 172 (7): 983–90. doi :10.1083/jcb.200508064 . PMC 2063756 PMID 16549498 .
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