Stuart Kauffman in April 2010
|Born||September 28, 1939|
|Alma mater||Dartmouth College|
University of California, San Francisco
|Known for||NK model, origin of life, gene regulatory networks, Adjacent Possible, Poised realm|
|Awards||Wiener Medal (1969)|
|Institutions||University of Chicago|
University of Pennsylvania
University of Calgary
Stuart Alan Kauffman (born September 28, 1939) is an American medical doctor, theoretical biologist, and complex systems researcher who studies the origin of life on Earth. He was a professor at the University of Chicago, University of Pennsylvania, and University of Calgary. He is currently emeritus professor of biochemistry at the University of Pennsylvania and affiliate faculty at the Institute for Systems Biology. He has a number of awards including a MacArthur Fellowship and a Wiener Medal.
He is best known for arguing that the complexity of biological systems and organisms might result as much from self-organization and far-from-equilibrium dynamics as from Darwinian natural selection as discussed in his book Origins of Order (1993). In 1967 and 1969 he used random boolean networks to investigate generic self-organizing properties of gene regulatory networks, proposing that cell types are dynamical attractors in gene regulatory networks and that cell differentiation can be understood as transitions between attractors. Recent evidence suggests that cell types in humans and other organisms are attractors. In 1971 he suggested that a zygote may not be able to access all the cell type attractors in its gene regulatory network during development and that some of the developmentally inaccessible cell types might be cancer cell types. This suggested the possibility of "cancer differentiation therapy". He also proposed the self-organized emergence of collectively autocatalytic sets of polymers, specifically peptides, for the origin of molecular reproduction, which have found experimental support.
Education and early career
Kauffman graduated from Dartmouth in 1960, was awarded the BA (Hons) by Oxford University (where he was a Marshall Scholar) in 1963, and completed a medical degree (M.D.) at the University of California, San Francisco in 1968. After completing his internship, he moved into developmental genetics of the fruitfly, holding appointments first at the University of Chicago from 1969 to 1973, the National Cancer Institute from 1973 to 1975, and then at the University of Pennsylvania from 1975 to 1994, where he rose to Professor of Biochemistry and Biophysics.
Kauffman became known through his association with the Santa Fe Institute (a non-profit research institute dedicated to the study of complex systems), where he was faculty in residence from 1986 to 1997, and through his work on models in various areas of biology. These included autocatalytic sets in origin of life research, gene regulatory networks in developmental biology, and fitness landscapes in evolutionary biology. With Marc Ballivet, Kauffman holds the founding broad biotechnology patents in combinatorial chemistry and applied molecular evolution, first issued in France in 1987 , in England in 1989, and later in the US.
In 1996, with Ernst and Young, Kauffman started BiosGroup, a Santa Fe, New Mexico-based for-profit company that applied complex systems methodology to business problems. BiosGroup was acquired by NuTech Solutions in early 2003. NuTech was bought by Netezza in 2008, and later by IBM.
From 2005 to 2009 Kauffman held a joint appointment at the University of Calgary in Biological Sciences and Physics and Astronomy. He was also an Adjunct Professor in the Department of Philosophy at the University of Calgary. He was an iCORE (Informatics Research Circle of Excellence) chair and the director of the Institute for Biocomplexity and Informatics. Kauffman was also invited to help launch the Science and Religion initiative at Harvard Divinity School; serving as Visiting Professor in 2009.
In January 2009 Kauffman became a Finland Distinguished Professor (FiDiPro) at Tampere University of Technology, Department of Signal Processing. The appointment ended in December, 2012. The subject of the FiDiPro research project is the development of delayed stochastic models of genetic regulatory networks based on gene expression data at the single molecule level.
In January 2010 Kauffman joined the University of Vermont faculty where he continued his work for two years with UVM's Complex Systems Center. From early 2011 to April 2013, Kauffman was a regular contributor to the NPR Blog 13.7, Cosmos and Culture, with topics ranging from the life sciences, systems biology, and medicine, to spirituality, economics, and the law . Kauffman is also a regular contributor to Edge.org. 
In May 2013 Kauffman joined the Institute for Systems Biology, in Seattle Washington. Following the death of his wife, with others, Kauffman cofounded Transforming Medicine: The Elizabeth Kauffman Institute. * 
In 2014, Kauffman with Samuli Niiranen and Gabor Vattay was issued a founding patent  on the poised realm (see below), an apparently new "state of matter" hovering reversibly between quantum and classical realms.
In 2015, Kauffman was invited to help initiate a general a discussion on rethinking economic growth for the United Nations. He is also currently doing research with University of Oxford Professor Teppo Felin.
Fulfilling an early desire to become a playwright, Kauffman also wrote two theatrical plays: "The Enlightenment of Reverend Joseph Smith" (2016) and a play, with Alex Cantarelli as a co-author, dedicated to the rescue of the Danish Jews in 1943, titled "The stones would weep" (2017).
In 2017, exploring the concept that reality consists of both ontologically real "Possibles" (Res potentia) and ontologically real "Actuals" (Res extensa), Kauffman co-authored, with Ruth Kastner and Michael Epperson: Taking Heisenberg's Potentia Seriously .
Kauffman's NK model defines a combinatorial phase space, consisting of every string (chosen from a given alphabet) of length . For each string in this search space, a scalar value (called the fitness) is defined. If a distance metric is defined between strings, the resulting structure is a landscape.
Fitness values are defined according to the specific incarnation of the model, but the key feature of the NK model is that the fitness of a given string is the sum of contributions from each locus in the string:
and the contribution from each locus in general depends on the value of other loci:
where are the other loci upon which the fitness of depends.
Hence, the fitness function is a mapping between strings of length K + 1 and scalars, which Weinberger's later work calls "fitness contributions". Such fitness contributions are often chosen randomly from some specified probability distribution.
In 1991, Weinberger published a detailed analysis of the case in which and the fitness contributions are chosen randomly. His analytical estimate of the number of local optima was later shown to be flawed. However, numerical experiments included in Weinberger's analysis support his analytical result that the expected fitness of a string is normally distributed with a mean of approximately and a variance of approximately .
Recognition and awards
Kauffman held a MacArthur Fellowship between 1987–1992. He also holds an Honorary Degree in Science from the University of Louvain (1997); He was awarded the Norbert Wiener Memorial Gold Medal for Cybernetics in 1973, the Gold Medal of the Accademia dei Lincei in Rome in 1990, the Trotter Prize for Information and Complexity in 2001, and the Herbert Simon award for Complex Systems in 2013. He became a Fellow of the Royal Society of Canada in 2009.
Kauffman is best known for arguing that the complexity of biological systems and organisms might result as much from self-organization and far-from-equilibrium dynamics as from Darwinian natural selection (See Origins of Order, 1993, below).
Some biologists and physicists working in Kauffman's area reserve judgment on Kauffman's claims about self-organization and evolution. A case in point is the introduction to the 2002 book Self Organization in Biological Systems (ISBN 978-0691116242). Roger Sansom's Ingenious Genes: How Gene Regulation Networks Evolve to Control Development (MIT Press, 2011) is an extended criticism of Kauffman's models.
Borrowing from spin glass models in physics, Kauffman invented "N-K" fitness landscapes, which have found applications in biology and economics. In related work, Kauffman and colleagues have examined subcritical, critical, and supracritical behavior in economic systems.
Kauffman with Longo and Montévil argue that, beyond the Newtonian paradigm, in the evolution of the biosphere and economy there can be no laws of motion and therefore no entailing laws.
Kauffman's work translates his biological findings to the mind-body problem and issues in neuroscience, proposing attributes of a new "poised realm" that hovers indefinitely between quantum coherence and classicality. He published on this topic in Answering Descartes: Beyond Turing (Kauffman, In press, Cambridge University; see below Kauffman, 2016). With Giuseppe Longo and Maël Montévil, he wrote (January 2012) "No entailing laws, but enablement in the evolution of the biosphere", which aims to show that evolution is not law entailed, as is physics, and that, without selection, evolution enables its own future possibilities.
Kauffman's work is posted on Physics ArXiv, including "Beyond the Stalemate: Mind/Body, Quantum Mechanics, Free Will, Possible Panpsychism, Possible Solution to the Quantum Enigma" (October 2014) and "Quantum Criticality at the Origin of Life" (February 2015) .
Kauffman has contributed to the emerging field of cumulative technological evolution by introducing a mathematics of the Adjacent Possible in his talk "The Shape of History"
He has published over 350 articles and 6 books: The Origins of Order (1993), At Home in the Universe (1995), Investigations (2000), Reinventing the Sacred (2008), Humanity in a Creative Universe (2016), and A World Beyond Physics (2019).
- Selected articles
- Kauffman, S. A.; McCulloch, W. S. (1967). "Random Nets of Formal Genes. Quarterly Progress Report 34". Research Laboratory of Electronics, Massachusetts Institute of Technology. Cite journal requires
|journal=(help)CS1 maint: ref=harv (link)
- Kauffman, Stuart (1969). "Metabolic stability and epigenesis in randomly constructed genetic nets". Journal of Theoretical Biology. 22 (3): 437–467. doi:10.1016/0022-5193(69)90015-0. PMID 5803332.CS1 maint: ref=harv (link)
- Kauffman, S. A. (1971a). "Cellular Homeostasis, Epigenesis, and Replication in Randomly Aggregated Macromolecular Systems". Journal of Cybernetics. 1: 71–96. doi:10.1080/01969727108545830.CS1 maint: ref=harv (link)
- Kauffman, S. A. (1971b). "Differentiation of Malignant to Benign Cells". Journal of Theoretical Biology. 31 (3): 429–451. doi:10.1016/0022-5193(71)90020-8. PMID 5556142.CS1 maint: ref=harv (link)
- Kauffman, Stuart (August 1991). "Antichaos and Adaptation" (PDF). Scientific American. 265 (2): 78–84. Bibcode:1991SciAm.265b..78K. doi:10.1038/scientificamerican0891-78. Retrieved April 28, 2015.
- Kauffman, S. A.; Johnsen, S (1991). "Co-Evolution to the Edge of Chaos: Coupled Fitness Landscapes, Poised States, and Co-Evolutionary Avalanches" (PDF). Journal of Theoretical Biology. 149 (4): 467–505. CiteSeerX 10.1.1.502.3299. doi:10.1016/s0022-5193(05)80094-3.CS1 maint: ref=harv (link)
- Kauffman, Stuart (2004). "Autonomous Agents". In Barrow, John D.; Davies, Paul C. W.; Harper, Charles L. Jr. (eds.). Science and Ultimate Reality: Quantum Theory, Cosmology, and Complexity. Cambridge University Press. ISBN 978-0521831130.
- Kauffman, Stuart (2004). "Prolegomenon to a General Biology". In Dembski, William A.; Ruse, Michael (eds.). Debating Design: From Darwin to DNA. Cambridge University Press. ISBN 978-1139459617.
- Kauffman, Stuart A. (November 12, 2006). "Beyond reductionism: Reinventing The Sacred". Edge.com. Edge Foundation. Retrieved April 28, 2015.
- Hanel, R.; Kauffman, S. A.; Thurner, S. (2007). "Towards a Physics of Evolution: Critical Diversity Dynamics at the Edges of Collapse and Bursts of Diversification". Physical Review E. 76 (3): 036110. Bibcode:2007PhRvE..76c6110H. doi:10.1103/physreve.76.036110. PMID 17930309.CS1 maint: ref=harv (link)
- Kauffman, Stuart (May 7, 2008). "Why Humanity Needs a God of Creativity". New Scientist. 198 (2655): 52–53. doi:10.1016/s0262-4079(08)61171-9. Retrieved April 28, 2015.
- Nykter, M.; Price, N. D.; Aldana, M.; Ramsey, S. A.; Kauffman, S. A.; Hood, L.; Yli-Harja, O.; Shmulevich, I. (2008). "Gene Expression Dynamics in the Macrophage Exhibit Criticality". Proc Natl Acad Sci USA. 105 (6): 1897–1900. Bibcode:2008PNAS..105.1897N. doi:10.1073/pnas.0711525105. PMC 2538855. PMID 18250330.CS1 maint: ref=harv (link)
- Huang, S.; Hu, L.; Kauffman, S.; Zhang, W.; Shmulevich, I. (2009). "Using cell fate attractors to uncover transcriptional regulation of HL60 neutrophil differentiation". BMC Systems Biology. 3: 20. doi:10.1186/1752-0509-3-20. PMC 2652435. PMID 19222862.CS1 maint: ref=harv (link)
- Huang, S.; Kauffman, S. A. (2009). "Complex Gene Regulatory Networks - from Structure to Biological Observables: Cell Fate Determination". In Meyers, R. A. (ed.). Encyclopedia of Complexity and Systems Science. Springer. ISBN 978-0-387-75888-6.CS1 maint: ref=harv (link)
- Kauffman, S. A. (2011). "Approaches to the Origin of Life on Earth". Life. 1 (1): 34–48. doi:10.3390/life1010034. PMC 4187126. PMID 25382055.CS1 maint: ref=harv (link)
- Longo, G.; Montévil, M.; Kauffman, S. (January 2012). "No entailing laws, but enablement in the evolution of the biosphere". arXiv:1201.2069 [q-bio.OT].CS1 maint: ref=harv (link)
- Kauffman, Stuart; Hill, Colin; Hood, Leroy; Huang, Sui (2014b). "Transforming Medicine: A Manifesto". Scientific American Worldview. Archived from the original on July 13, 2014. Retrieved April 28, 2015.CS1 maint: ref=harv (link)
- Kauffman, Stuart (October 2014). "Beyond the Stalemate: Conscious Mind-Body - Quantum Mechanics - Free Will - Possible Panpsychism - Possible Interpretation of Quantum Enigma". arXiv:1410.2127 [physics.hist-ph].CS1 maint: ref=harv (link)
- Felin, T.; Kauffman, S.; Koppl, R.; Longo, G. (December 2014). "Economic Opportunity and Evolution: Beyond Landscapes and Bounded Rationality" (PDF). Strategic Entrepreneurship Journal. 8 (4): 269–282. doi:10.1002/sej.1184. SSRN 2197512.CS1 maint: ref=harv (link)
- Vattay, G.; Salahub, D.; Csaibai, I.; Nassmi, A.; Kauffman, S. (February 2015). "Quantum Criticality at the Origin of Life". Journal of Physics: Conference Series. 626: 012023. arXiv:1502.06880. doi:10.1088/1742-6596/626/1/012023.CS1 maint: ref=harv (link)
- Kauffman, S. (2016). "Answering Descartes: Beyond Turing". In Cooper, S. Barry; Hodges, Andrew (eds.). The Once and Future Turing. Cambridge University Press.CS1 maint: ref=harv (link)
- Kauffman, Stuart (1993). The Origins of Order: Self Organization and Selection in Evolution. Oxford University Press. ISBN 978-0-19-507951-7.
- Kauffman, Stuart (1995). At Home in the Universe: The Search for Laws of Self-Organization and Complexity. Oxford University Press. ISBN 978-0195111309.
- Kauffman, Stuart (2000). Investigations. Oxford University Press. ISBN 978-0199728947.
- Kauffman, Stuart (2008). Reinventing the Sacred: A New View of Science, Reason, and Religion. Basic Books. ISBN 978-0-465-00300-6.
- Kauffman, Stuart (2016). Humanity in a Creative Universe. Oxford University Press. ISBN 978-0-19-939045-8.
- Kauffman, Stuart (2019). A World Beyond Physics. Oxford University Press. ISBN 978-0-19-087133-8.
- Kauffman & McCulloch 1967.
- Kauffman 1969.
- Huang & Kauffman 2009.
- Nykter et al. 2008.
- Kauffman 1971b.
- Kauffman 1971a.
- Kauffman 2011.
- Dadon, Wagner & Ashkenasy 2008.
- Dadon et al. 2012.
- US 5,723,323 "Method of identifying a stochastically-generated peptide, polypeptide, or protein having ligand binding property and compositions thereof."
- "NuTech Solutions to Acquire BiosGroup's Software Development Operations". BusinessWire. February 20, 2003. Retrieved July 5, 2015.
- "Netezza Corporation Acquires NuTech Solutions". BusinessWire. May 15, 2008. Retrieved July 5, 2015.
- "IBM to Acquire Netezza". IBM News Room. IBM. September 20, 2010. Retrieved July 5, 2015.
- "Stuart Kauffman, complex systems pioneer, to join UVM faculty". Vermontbiz.com. Vermont Business Magazine. September 30, 2009. Retrieved April 28, 2015.
- "Stuart Kauffman". NPR.org. Retrieved April 28, 2015.
- "Stuart A. Kauffman". Edge.org. Edge Foundation. Retrieved April 28, 2015.
- Kauffman et al. 2014b.
- Vattay et al. 2015.
- Felin, Teppo; Kauffman, Stuart; Koppl, Roger; Longo, Giuseppe (2014). "Economic opportunity and evolution: Beyond landscapes and bounded rationality" (PDF). Strategic Entrepreneurship Journal. 8 (4): 269–282. doi:10.1002/sej.1184.
- Weinberger, Edward (November 15, 1991). "Local properties of Kauffman's N-k model: A tunably rugged energy landscape". Physical Review A. 10. 44 (10): 6399–6413. Bibcode:1991PhRvA..44.6399W. doi:10.1103/physreva.44.6399.
- Kauffman & Johnsen 1991.
- Rivkin & Siggelkow 2002.
- Felin et al. 2014. sfn error: multiple targets (2×): CITEREFFelinKauffmanKopplLongo2014 (help)
- Hanel, Kauffman & Thurner 2007.
- Longo, Montévil & Kauffman 2012.
- Kauffman 2014.
- Chialvo, D. R. (2013). "Critical Brain Dynamics at Large Scale". In Plenz D.; Niebur, E.; Schuster H. G. (eds.). Criticality in Neural Systems. 1. Wiley. ISBN 978-3-527-41104-7.CS1 maint: ref=harv (link)
- Dadon, Z.; Wagner, N.; Ashkenasy, G. (2008). "The Road to Non-Enzymatic Molecular Networks". Angew. Chem. Int. Ed. 47 (33): 6128–6136. doi:10.1002/anie.200702552. PMID 18613152.CS1 maint: ref=harv (link)
- Dadon, Z.; Wagner, N.; Cohen-Luria, R.; Ashkenasy, G. (2012). "Reaction Networks. Wagner and Askkenazy's (2008) results demonstrate that molecular replication need not be based on DNA or RNA template replication, still the dominate view for the origin of life". In Gale, P. A.; Steed J. W. (eds.). Supramolecular Chemistry: From Molecules to Nanomaterials. John Wiley and Sons, Ltd. ISBN 978-0-470-74640-0.CS1 maint: ref=harv (link)
- Rivkin, J. W.; Siggelkow, N. (May–June 2002). "Organizational Sticking Points on NK Landscapes". Complexity. 7 (5): 31–43. Bibcode:2002Cmplx...7e..31R. doi:10.1002/cplx.10037. Retrieved April 28, 2015.CS1 maint: ref=harv (link)
- Di Bernardo, Mirko (2011). I sentieri evolutivi della complessità biologica nell'opera di S. A. Kauffman (in Italian). Milano: Mimesis. ISBN 978-8857504131.
- Goldstein, Jeffrey A. (2008). "Book Review of Reinventing the Sacred: A New View of Science, Reason, and Religion, by Stuart Kauffman". Emergence: Complexity & Organization. 10 (3): 117–130.
- Horgan, John (February 4, 2015). "Seeker Stuart Kauffman on Free Will, God, ESP and Other Mysteries". Scientific American. Retrieved April 28, 2015.
- MacKenzie, Dana (February 2002). "The Science of Surprise". Discover. 23 (2): 59–63.
- Rizzo, Francesco (2017). "Kauffman lettore di Wittgenstein" (in Italian). Palermo: Università degli studi di Palermo. Cite journal requires
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- Paulson, Steve (November 9, 2008). "God Enough". Salon. Retrieved April 28, 2015.
- Thinker of Untold Dreams: A Portrait of Stuart Kauffman
- The Shape of History: A talk at the New England Complex Systems Institute, January 28, 2019