|— Wikipedian ♂ —
|Name in real life
||Native Swedish. Basic knowledge of English.
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||The Cure Award
|In 2013 you were one of the top 300 medical editors across any language of Wikipedia. Thank you so much for helping bring free, complete, accurate, up-to-date medical information to the public. We really appreciate you and the vital work you do!
- 2011 Sangrampur methanol tragedy
- 3 A.M. Vodka
- College student alcoholism
- Comparison of web search engines
- Legality of Bitcoins by country
- List of amylase induced fermentations
- List of methanol poisoning incidents
- Long-term impact of alcohol on the brain
A depressogenic substance (or depressogen) is one that causes or can cause depression, usually as a side effect. They are the functional opposites of antidepressants.
Examples of drugs commonly associated with depressogenic effects include some anticonvulsants such as the barbiturates (e.g. phenobarbital), benzodiazepines (e.g. diazepam), vigabatrin, and topiramate, corticosteroids like dexamethasone and prednisone, cytokines like interferon-α and interleukin-2, certain antihypertensives such as amiodarone, clonidine, methyldopa, reserpine, and tetrabenazine (used as an antipsychotic/antihyperkinetic), and agents with antiandrogen, antiestrogen, and/or anti-neurosteroid activities such as GnRH agonists (e.g., leuprolide, goserelin), anastrozole (an aromatase inhibitor), finasteride (a 5α-reductase inhibitor), and clomiphene (a SERM), as well as others including flunarizine, mefloquine, and efavirenz. Another notable agent is rimonabant, a cannabinoid receptor antagonist marketed as an anti-obesity agent which was withdrawn shortly after its introduction due to the incidence of severe psychiatric side effects associated with its use including depression, anxiety, and suicidal ideation.
Examples of endogenous compounds that have been implicated in stress and depression include corticotropin-releasing hormone (CRH), cytokines (e.g., interferon-α, interleukin-2), tachykinins (e.g., substance P), glucocorticoids (e.g., cortisol, cortisone), and dynorphin.
- ^ a b Celano CM, Freudenreich O, Fernandez-Robles C, Stern TA, Caro MA, Huffman JC (2011). "Depressogenic effects of medications: a review". Dialogues in Clinical Neuroscience. 13 (1): 109–25. PMC 3181967 . PMID 21485751.
- ^ Belmaker RH (August 2008). "The future of depression psychopharmacology". CNS Spectrums. 13 (8): 682–7. PMID 18704023.
- ^ Beers MH, Passman LJ (December 1990). "Antihypertensive medications and depression". Drugs. 40 (6): 792–9. PMID 2078996. doi:10.2165/00003495-199040060-00003.
- ^ Kenney C, Hunter C, Mejia N, Jankovic J (2006). "Is history of depression a contraindication to treatment with tetrabenazine?". Clinical Neuropharmacology. 29 (5): 259–64. PMID 16960470. doi:10.1097/01.WNF.0000228369.25593.35.
- ^ Finn DA, Beadles-Bohling AS, Beckley EH, et al. (2006). "A new look at the 5alpha-reductase inhibitor finasteride". CNS Drug Reviews. 12 (1): 53–76. PMID 16834758. doi:10.1111/j.1527-3458.2006.00053.x.
- ^ Moreira FA, Crippa JA (June 2009). "The psychiatric side-effects of rimonabant". Revista Brasileira De Psiquiatria (São Paulo, Brazil : 1999). 31 (2): 145–53. PMID 19578688. doi:10.1590/s1516-44462009000200012.
- ^ a b c Norman TR, Burrows GD (February 2007). "Emerging treatments for major depression". Expert Review of Neurotherapeutics. 7 (2): 203–13. PMID 17286553. doi:10.1586/14737184.108.40.206.
- ^ a b Stokes PE, Sikes CR (February 1988). "The hypothalamic-pituitary-adrenocortical axis in major depression". Neurologic Clinics. 6 (1): 1–19. PMID 2837631.
- ^ Gibb J, Audet MC, Hayley S, Anisman H (2009). "Neurochemical and behavioral responses to inflammatory immune stressors". Frontiers in Bioscience (Scholar Edition). 1: 275–95. PMID 19482702. doi:10.2741/e26.
- ^ Knoll AT, Carlezon WA (February 2010). "Dynorphin, stress, and depression". Brain Research. 1314: 56–73. PMC 2819644 . PMID 19782055. doi:10.1016/j.brainres.2009.09.074.
Top edited articles
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Major improved articles
||Studies have found trace quantities of endogenous alcohols of healthy volunteers from exhaled breath with a mean of 450 ppb methanol and 244 ppb ethanol. The mean endogenous methanol in humans of 0.45 g/d may be metabolized from pectin found in fruit; One kilos of apple produces up to 1.4 gram methanol. However, methanol should never consumed on its own as it is poisonous to the central nervous system, and may cause blindness, coma, and death. These studies are not guidelines that consumption of alcohol found in alcoholic beverages are healthy.
||CBD does not induce the psychoactive high typically associated with recreational marijuana strains that are high in THC, not even in high doses.
||Hemp Industries Association said in 2014 that hemp seed oil is less than 25 parts per million CBD, thus hemp oil is not a source of CBD Which could be used in epilepsy treatments.
|Microchip implant (human)
And it will cause all, the small and the great, and the poor, and the free and the bond to have a mark on their right hand or on their foreheads and it will bring it about that no one may be able to buy or sell, except him who has the mark, either the name of the beast or the number of its name.
— Apocalypse 13:16-17, Confraternity Edition Bible 1941
|National Security Agency
||Linus Torvalds, the founder of Linux kernel joked during a LinuxCon keynote 18 September 2013, that the NSA, who is the founder of SELinux, wanted a backdoor in the kernel. However later, Linus father, Member of the European Parliament (MEP), revealed that the NSA actually did this.
When my oldest son [Linus Torvalds] was asked the same question: “Has he been approached by the NSA about backdoors?” he said “No”, but at the same time he nodded. Then he was sort of in the legal free. He had given the right answer, [but] everybody understood that the NSA had approached him.
— Nils Torvalds, LIBE Committee Inquiry on Electronic Mass Surveillance of EU Citizens - 11th Hearing, 11 November 2013
||Stallman admire whistleblower Julian Assange, and Edward Snowden who he advocate in hes email signature after Snowden leaked the PRISM scandal in 2013 that can be found in several mailing-lists:
To any NSA and FBI agents reading my email: please consider whether defending the US Constitution against all enemies, foreign or domestic, requires you to follow Snowden's example.
— Richard Stallman
Drug research aimed to develop non-recreational drugs from typical recreational drugs.
- This user has contributed to 27 Good Articles on Wikipedia.
- This user has created 1,001 of the 5,390,134 articles on the English Language Wikipedia
User page design center
Autoformat tool for citations
Please stop adding bare URLs to Wikipedia.
You will notice the autoformat tool for citations when you are in an edit window, that up at the top there is a toolbar. On the right, it says "Cite" and there is a little triangle next to it. If you click the triangle, another menu appears below. On the left side of the new menu bar, you will see "Templates". If you select (for example) "Cite journal", you can fill in the "doi" or the "PMID" field, and then if you click the little magnifying glass next to the field, the whole thing will auto-fill. Then you click the "insert" button at the bottom, and it will insert a ref like this (I changed the ref tags so it shows):
- (ref) Huhtaniemi, I (2014). "Late-onset hypogonadism: current concepts and controversies of pathogenesis, diagnosis and treatment.". Asian journal of andrology. 16 (2): 192–202. PMID 24407185. (/ref)
That takes about 10 seconds, if even that. As you can see there are templates for books, news, and websites, as well as journal articles, and each template has at least one field that you can use to autofill the rest. The autofill isn't perfect and I usually have to manually fix some things before I click "insert" but it generally works great and saves a bunch of time.
The PMID parameter is the one we care about the most on articles about health.
One thing the autofill doesn't do, is add the PMC field if it is there (PMC is a link to a free fulltext version of the article). you can add that after you insert the citation, or -- while you have the "cite journal" template open -- you can click the "show/hide extra fields" button at the bottom, and you will see the PMC field on the right, near the bottom. If you add the PMC number there that will be included, like this (again I have changed the ref tags):
- (ref) Huhtaniemi, I (2014). "Late-onset hypogonadism: current concepts and controversies of pathogenesis, diagnosis and treatment.". Asian journal of andrology. 16 (2): 192–202. PMC 3955328 . PMID 24407185. (/ref)
The autofill also doesn't add the URL if there is a free fulltext that is not in PMC. You can add that manually too, after you autofill with PMID
Thanks. Jytdog (talk) 04:17, 7 May 2017 (UTC)
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