Log page index: User:ProteinBoxBot/PBB_Log_Index
Protein Status Quick Log - Date: 07:49, 18 November 2007 (UTC)[edit]
Proteins without matches (8)[edit]
Proteins with a High Potential Match (2)[edit]
Redirected Proteins (15)[edit]
Manual Inspection (Page not found) (10)[edit]
Updated (15)[edit]
Protein Status Grid - Date: 07:49, 18 November 2007 (UTC)[edit]
Vebose Log - Date: 07:49, 18 November 2007 (UTC)[edit]
- INFO: Beginning work on ADAMTS4... {November 17, 2007 11:38:06 PM PST}
- SEARCH REDIRECT: Control Box Found: ADAMTS4 {November 17, 2007 11:38:38 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 17, 2007 11:38:41 PM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {November 17, 2007 11:38:41 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 17, 2007 11:38:41 PM PST}
- UPDATED: Updated protein page: ADAMTS4 {November 17, 2007 11:38:47 PM PST}
- INFO: Beginning work on AKR1C3... {November 17, 2007 11:33:03 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 17, 2007 11:33:46 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_AKR1C3_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1ry0.
| PDB = {{PDB2|1ry0}}, {{PDB2|1ry8}}, {{PDB2|1s1p}}, {{PDB2|1s1r}}, {{PDB2|1s2a}}, {{PDB2|1s2c}}, {{PDB2|1xf0}}, {{PDB2|1zq5}}, {{PDB2|2f38}}, {{PDB2|2fgb}}
| Name = Aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
| HGNCid = 386
| Symbol = AKR1C3
| AltSymbols =; DD3; HA1753; HAKRB; HAKRe; HSD17B5; KIAA0119; hluPGFS
| OMIM = 603966
| ECnumber =
| Homologene = 81636
| MGIid = 2145420
| GeneAtlas_image1 = PBB_GE_AKR1C3_209160_at_tn.png
| GeneAtlas_image2 = PBB_GE_AKR1C3_211653_x_at_tn.png
| Function = {{GNF_GO|id=GO:0004033 |text = aldo-keto reductase activity}} {{GNF_GO|id=GO:0004303 |text = estradiol 17-beta-dehydrogenase activity}} {{GNF_GO|id=GO:0016491 |text = oxidoreductase activity}} {{GNF_GO|id=GO:0047017 |text = prostaglandin-F synthase activity}} {{GNF_GO|id=GO:0047026 |text = 3-alpha-hydroxysteroid dehydrogenase (A-specific) activity}} {{GNF_GO|id=GO:0047115 |text = trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}}
| Process = {{GNF_GO|id=GO:0006118 |text = electron transport}} {{GNF_GO|id=GO:0006693 |text = prostaglandin metabolic process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 8644
| Hs_Ensembl = ENSG00000196139
| Hs_RefseqProtein = NP_003730
| Hs_RefseqmRNA = NM_003739
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 10
| Hs_GenLoc_start = 5125985
| Hs_GenLoc_end = 5139878
| Hs_Uniprot = P42330
| Mm_EntrezGene = 105349
| Mm_Ensembl = ENSMUSG00000021214
| Mm_RefseqmRNA = NM_134066
| Mm_RefseqProtein = NP_598827
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 13
| Mm_GenLoc_start = 4131870
| Mm_GenLoc_end = 4149877
| Mm_Uniprot = Q3U538
}}
}}
'''Aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)''', also known as '''AKR1C3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: AKR1C3 aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8644| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9alpha,11beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14.<ref name="entrez">{{cite web | title = Entrez Gene: AKR1C3 aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8644| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Lin SX, Shi R, Qiu W, ''et al.'' |title=Structural basis of the multispecificity demonstrated by 17beta-hydroxysteroid dehydrogenase types 1 and 5. |journal=Mol. Cell. Endocrinol. |volume=248 |issue= 1-2 |pages= 38-46 |year= 2006 |pmid= 16480815 |doi= 10.1016/j.mce.2005.11.035 }}
*{{cite journal | author=Khanna M, Qin KN, Cheng KC |title=Distribution of 3 alpha-hydroxysteroid dehydrogenase in rat brain and molecular cloning of multiple cDNAs encoding structurally related proteins in humans. |journal=J. Steroid Biochem. Mol. Biol. |volume=53 |issue= 1-6 |pages= 41-6 |year= 1995 |pmid= 7626489 |doi= }}
*{{cite journal | author=Khanna M, Qin KN, Wang RW, Cheng KC |title=Substrate specificity, gene structure, and tissue-specific distribution of multiple human 3 alpha-hydroxysteroid dehydrogenases. |journal=J. Biol. Chem. |volume=270 |issue= 34 |pages= 20162-8 |year= 1995 |pmid= 7650035 |doi= }}
*{{cite journal | author=Nagase T, Miyajima N, Tanaka A, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1. |journal=DNA Res. |volume=2 |issue= 1 |pages= 37-43 |year= 1995 |pmid= 7788527 |doi= }}
*{{cite journal | author=Khanna M, Qin KN, Klisak I, ''et al.'' |title=Localization of multiple human dihydrodiol dehydrogenase (DDH1 and DDH2) and chlordecone reductase (CHDR) genes in chromosome 10 by the polymerase chain reaction and fluorescence in situ hybridization. |journal=Genomics |volume=25 |issue= 2 |pages= 588-90 |year= 1995 |pmid= 7789999 |doi= }}
*{{cite journal | author=Qin KN, New MI, Cheng KC |title=Molecular cloning of multiple cDNAs encoding human enzymes structurally related to 3 alpha-hydroxysteroid dehydrogenase. |journal=J. Steroid Biochem. Mol. Biol. |volume=46 |issue= 6 |pages= 673-9 |year= 1994 |pmid= 8274401 |doi= }}
*{{cite journal | author=Bennett MJ, Schlegel BP, Jez JM, ''et al.'' |title=Structure of 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase complexed with NADP+. |journal=Biochemistry |volume=35 |issue= 33 |pages= 10702-11 |year= 1996 |pmid= 8718859 |doi= 10.1021/bi9604688 }}
*{{cite journal | author=Lin HK, Jez JM, Schlegel BP, ''et al.'' |title=Expression and characterization of recombinant type 2 3 alpha-hydroxysteroid dehydrogenase (HSD) from human prostate: demonstration of bifunctional 3 alpha/17 beta-HSD activity and cellular distribution. |journal=Mol. Endocrinol. |volume=11 |issue= 13 |pages= 1971-84 |year= 1998 |pmid= 9415401 |doi= }}
*{{cite journal | author=Matsuura K, Shiraishi H, Hara A, ''et al.'' |title=Identification of a principal mRNA species for human 3alpha-hydroxysteroid dehydrogenase isoform (AKR1C3) that exhibits high prostaglandin D2 11-ketoreductase activity. |journal=J. Biochem. |volume=124 |issue= 5 |pages= 940-6 |year= 1999 |pmid= 9792917 |doi= }}
*{{cite journal | author=Mills KI, Gilkes AF, Sweeney M, ''et al.'' |title=Identification of a retinoic acid responsive aldoketoreductase expressed in HL60 leukaemic cells. |journal=FEBS Lett. |volume=440 |issue= 1-2 |pages= 158-62 |year= 1999 |pmid= 9862446 |doi= }}
*{{cite journal | author=Dufort I, Rheault P, Huang XF, ''et al.'' |title=Characteristics of a highly labile human type 5 17beta-hydroxysteroid dehydrogenase. |journal=Endocrinology |volume=140 |issue= 2 |pages= 568-74 |year= 1999 |pmid= 9927279 |doi= }}
*{{cite journal | author=Rheault P, Dufort I, Soucy P, Luu-The V |title=Assignment of HSD17B5 encoding type 5 17 beta-hydroxysteroid dehydrogenase to human chromosome bands 10p15-->p14 and mouse chromosome 13 region A2 by in situ hybridization: identification of a new syntenic relationship. |journal=Cytogenet. Cell Genet. |volume=84 |issue= 3-4 |pages= 241-2 |year= 1999 |pmid= 10393440 |doi= }}
*{{cite journal | author=Griffin LD, Mellon SH |title=Selective serotonin reuptake inhibitors directly alter activity of neurosteroidogenic enzymes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 23 |pages= 13512-7 |year= 1999 |pmid= 10557352 |doi= }}
*{{cite journal | author=Suzuki-Yamamoto T, Nishizawa M, Fukui M, ''et al.'' |title=cDNA cloning, expression and characterization of human prostaglandin F synthase. |journal=FEBS Lett. |volume=462 |issue= 3 |pages= 335-40 |year= 2000 |pmid= 10622721 |doi= }}
*{{cite journal | author=Nishizawa M, Nakajima T, Yasuda K, ''et al.'' |title=Close kinship of human 20alpha-hydroxysteroid dehydrogenase gene with three aldo-keto reductase genes. |journal=Genes Cells |volume=5 |issue= 2 |pages= 111-25 |year= 2000 |pmid= 10672042 |doi= }}
*{{cite journal | author=Penning TM, Burczynski ME, Jez JM, ''et al.'' |title=Human 3alpha-hydroxysteroid dehydrogenase isoforms (AKR1C1-AKR1C4) of the aldo-keto reductase superfamily: functional plasticity and tissue distribution reveals roles in the inactivation and formation of male and female sex hormones. |journal=Biochem. J. |volume=351 |issue= Pt 1 |pages= 67-77 |year= 2001 |pmid= 10998348 |doi= }}
*{{cite journal | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788-95 |year= 2001 |pmid= 11076863 |doi= }}
*{{cite journal | author=Penning TM, Burczynski ME, Jez JM, ''et al.'' |title=Structure-function aspects and inhibitor design of type 5 17beta-hydroxysteroid dehydrogenase (AKR1C3). |journal=Mol. Cell. Endocrinol. |volume=171 |issue= 1-2 |pages= 137-49 |year= 2001 |pmid= 11165022 |doi= }}
*{{cite journal | author=Simpson JC, Wellenreuther R, Poustka A, ''et al.'' |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287-92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CAMK2B... {November 17, 2007 11:20:35 PM PST}
- SEARCH REDIRECT: Control Box Found: CAMK2B {November 17, 2007 11:21:44 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 17, 2007 11:21:45 PM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {November 17, 2007 11:21:45 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 17, 2007 11:21:45 PM PST}
- UPDATED: Updated protein page: CAMK2B {November 17, 2007 11:21:57 PM PST}
- INFO: Beginning work on CCNA1... {November 17, 2007 11:35:56 PM PST}
- SEARCH REDIRECT: Control Box Found: CCNA1 {November 17, 2007 11:36:24 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 17, 2007 11:36:27 PM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {November 17, 2007 11:36:27 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 17, 2007 11:36:27 PM PST}
- UPDATED: Updated protein page: CCNA1 {November 17, 2007 11:36:33 PM PST}
- INFO: Beginning work on CD3G... {November 17, 2007 11:21:57 PM PST}
- SEARCH REDIRECT: Control Box Found: CD3G {November 17, 2007 11:22:39 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 17, 2007 11:22:48 PM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {November 17, 2007 11:22:48 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 17, 2007 11:22:48 PM PST}
- UPDATED: Updated protein page: CD3G {November 17, 2007 11:22:58 PM PST}
- INFO: Beginning work on CDC37... {November 17, 2007 11:40:23 PM PST}
- SEARCH REDIRECT: Control Box Found: CDC37 {November 17, 2007 11:40:47 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 17, 2007 11:40:48 PM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {November 17, 2007 11:40:48 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 17, 2007 11:40:48 PM PST}
- UPDATED: Updated protein page: CDC37 {November 17, 2007 11:40:55 PM PST}
- INFO: Beginning work on CDC6... {November 17, 2007 11:22:58 PM PST}
- SEARCH REDIRECT: Control Box Found: CDC6 {November 17, 2007 11:23:54 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 17, 2007 11:24:00 PM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {November 17, 2007 11:24:00 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 17, 2007 11:24:00 PM PST}
- UPDATED: Updated protein page: CDC6 {November 17, 2007 11:24:12 PM PST}
- INFO: Beginning work on CDH3... {November 17, 2007 11:24:12 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 17, 2007 11:25:04 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Cadherin 3, type 1, P-cadherin (placental)
| HGNCid = 1762
| Symbol = CDH3
| AltSymbols =; CDHP; HJMD; PCAD
| OMIM = 114021
| ECnumber =
| Homologene = 20425
| MGIid = 88356
| GeneAtlas_image1 = PBB_GE_CDH3_203256_at_tn.png
| Function = {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007156 |text = homophilic cell adhesion}} {{GNF_GO|id=GO:0007601 |text = visual perception}} {{GNF_GO|id=GO:0050896 |text = response to stimulus}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1001
| Hs_Ensembl = ENSG00000062038
| Hs_RefseqProtein = NP_001784
| Hs_RefseqmRNA = NM_001793
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 16
| Hs_GenLoc_start = 67236240
| Hs_GenLoc_end = 67290440
| Hs_Uniprot = P22223
| Mm_EntrezGene = 12560
| Mm_Ensembl = ENSMUSG00000061048
| Mm_RefseqmRNA = XM_001000165
| Mm_RefseqProtein = XP_001000165
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 8
| Mm_GenLoc_start = 109400042
| Mm_GenLoc_end = 109446037
| Mm_Uniprot = Q80VY6
}}
}}
'''Cadherin 3, type 1, P-cadherin (placental)''', also known as '''CDH3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CDH3 cadherin 3, type 1, P-cadherin (placental)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1001| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. This gene is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. In addition, aberrant expression of this protein is observed in cervical adenocarcinomas. Mutations in this gene have been associated with congential hypotrichosis with juvenile macular dystrophy.<ref name="entrez">{{cite web | title = Entrez Gene: CDH3 cadherin 3, type 1, P-cadherin (placental)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1001| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Kaupmann K, Becker-Follmann J, Scherer G, ''et al.'' |title=The gene for the cell adhesion molecule M-cadherin maps to mouse chromosome 8 and human chromosome 16q24.1-qter and is near the E-cadherin (uvomorulin) locus in both species. |journal=Genomics |volume=14 |issue= 2 |pages= 488-90 |year= 1992 |pmid= 1427864 |doi= }}
*{{cite journal | author=Herrenknecht K, Ozawa M, Eckerskorn C, ''et al.'' |title=The uvomorulin-anchorage protein alpha catenin is a vinculin homologue. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=88 |issue= 20 |pages= 9156-60 |year= 1991 |pmid= 1924379 |doi= }}
*{{cite journal | author=Shimoyama Y, Hirohashi S, Hirano S, ''et al.'' |title=Cadherin cell-adhesion molecules in human epithelial tissues and carcinomas. |journal=Cancer Res. |volume=49 |issue= 8 |pages= 2128-33 |year= 1989 |pmid= 2702654 |doi= }}
*{{cite journal | author=Shimoyama Y, Yoshida T, Terada M, ''et al.'' |title=Molecular cloning of a human Ca2+-dependent cell-cell adhesion molecule homologous to mouse placental cadherin: its low expression in human placental tissues. |journal=J. Cell Biol. |volume=109 |issue= 4 Pt 1 |pages= 1787-94 |year= 1989 |pmid= 2793940 |doi= }}
*{{cite journal | author=Palacios J, Benito N, Pizarro A, ''et al.'' |title=Anomalous expression of P-cadherin in breast carcinoma. Correlation with E-cadherin expression and pathological features. |journal=Am. J. Pathol. |volume=146 |issue= 3 |pages= 605-12 |year= 1995 |pmid= 7534041 |doi= }}
*{{cite journal | author=van der Linden PJ, de Goeij AF, Dunselman GA, ''et al.'' |title=Expression of cadherins and integrins in human endometrium throughout the menstrual cycle. |journal=Fertil. Steril. |volume=63 |issue= 6 |pages= 1210-6 |year= 1995 |pmid= 7538474 |doi= }}
*{{cite journal | author=Tang A, Eller MS, Hara M, ''et al.'' |title=E-cadherin is the major mediator of human melanocyte adhesion to keratinocytes in vitro. |journal=J. Cell. Sci. |volume=107 ( Pt 4) |issue= |pages= 983-92 |year= 1994 |pmid= 8056851 |doi= }}
*{{cite journal | author=Tassin MT, Beziau A, Gubler MC, Boyer B |title=Spatiotemporal expression of molecules associated with junctional complexes during the in vivo maturation of renal podocytes. |journal=Int. J. Dev. Biol. |volume=38 |issue= 1 |pages= 45-54 |year= 1994 |pmid= 8074995 |doi= }}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
*{{cite journal | author=Navarro P, Lozano E, Cano A |title=Expression of E- or P-cadherin is not sufficient to modify the morphology and the tumorigenic behavior of murine spindle carcinoma cells. Possible involvement of plakoglobin. |journal=J. Cell. Sci. |volume=105 ( Pt 4) |issue= |pages= 923-34 |year= 1993 |pmid= 8227214 |doi= }}
*{{cite journal | author=Reynolds AB, Daniel JM, Mo YY, ''et al.'' |title=The novel catenin p120cas binds classical cadherins and induces an unusual morphological phenotype in NIH3T3 fibroblasts. |journal=Exp. Cell Res. |volume=225 |issue= 2 |pages= 328-37 |year= 1996 |pmid= 8660921 |doi= 10.1006/excr.1996.0183 }}
*{{cite journal | author=Soler AP, Harner GD, Knudsen KA, ''et al.'' |title=Expression of P-cadherin identifies prostate-specific-antigen-negative cells in epithelial tissues of male sexual accessory organs and in prostatic carcinomas. Implications for prostate cancer biology. |journal=Am. J. Pathol. |volume=151 |issue= 2 |pages= 471-8 |year= 1997 |pmid= 9250159 |doi= }}
*{{cite journal | author=Wakita H, Furukawa F, Baba S, Takigawa M |title=Human squamous-cell-carcinoma cell line (DJM-1) cells synthesize P-cadherin molecules via an elevation of extracellular calcium: calcium regulates P-cadherin-gene expression at the translational level via protein tyrosine phosphorylation. |journal=Int. J. Cancer |volume=73 |issue= 3 |pages= 432-9 |year= 1997 |pmid= 9359492 |doi= }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
*{{cite journal | author=Kremmidiotis G, Baker E, Crawford J, ''et al.'' |title=Localization of human cadherin genes to chromosome regions exhibiting cancer-related loss of heterozygosity. |journal=Genomics |volume=49 |issue= 3 |pages= 467-71 |year= 1998 |pmid= 9615235 |doi= 10.1006/geno.1998.5281 }}
*{{cite journal | author=Jarrard DF, Paul R, van Bokhoven A, ''et al.'' |title=P-Cadherin is a basal cell-specific epithelial marker that is not expressed in prostate cancer. |journal=Clin. Cancer Res. |volume=3 |issue= 11 |pages= 2121-8 |year= 1999 |pmid= 9815605 |doi= }}
*{{cite journal | author=Schmeiser K, Grand RJ |title=The fate of E- and P-cadherin during the early stages of apoptosis. |journal=Cell Death Differ. |volume=6 |issue= 4 |pages= 377-86 |year= 1999 |pmid= 10381631 |doi= 10.1038/sj.cdd.4400504 }}
*{{cite journal | author=Rufas O, Fisch B, Ziv S, Shalgi R |title=Expression of cadherin adhesion molecules on human gametes. |journal=Mol. Hum. Reprod. |volume=6 |issue= 2 |pages= 163-9 |year= 2000 |pmid= 10655458 |doi= }}
*{{cite journal | author=Klingelhöfer J, Troyanovsky RB, Laur OY, Troyanovsky S |title=Amino-terminal domain of classic cadherins determines the specificity of the adhesive interactions. |journal=J. Cell. Sci. |volume=113 ( Pt 16) |issue= |pages= 2829-36 |year= 2000 |pmid= 10910767 |doi= }}
*{{cite journal | author=Han AC, Edelson MI, Peralta Soler A, ''et al.'' |title=Cadherin expression in glandular tumors of the cervix. |journal=Cancer |volume=89 |issue= 10 |pages= 2053-8 |year= 2000 |pmid= 11066045 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CYP2C8... {November 17, 2007 11:25:05 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 17, 2007 11:25:53 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_CYP2C8_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1pq2.
| PDB = {{PDB2|1pq2}}
| Name = Cytochrome P450, family 2, subfamily C, polypeptide 8
| HGNCid = 2622
| Symbol = CYP2C8
| AltSymbols =; CPC8; P450 MP-12/MP-20
| OMIM = 601129
| ECnumber =
| Homologene = 68086
| MGIid = 1917138
| GeneAtlas_image1 = PBB_GE_CYP2C8_208147_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004497 |text = monooxygenase activity}} {{GNF_GO|id=GO:0005506 |text = iron ion binding}} {{GNF_GO|id=GO:0020037 |text = heme binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}} {{GNF_GO|id=GO:0050381 |text = unspecific monooxygenase activity}}
| Component = {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0005792 |text = microsome}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006118 |text = electron transport}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1558
| Hs_Ensembl = ENSG00000138115
| Hs_RefseqProtein = NP_000761
| Hs_RefseqmRNA = NM_000770
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 10
| Hs_GenLoc_start = 96786520
| Hs_GenLoc_end = 96819244
| Hs_Uniprot = P10632
| Mm_EntrezGene = 69888
| Mm_Ensembl = ENSMUSG00000067229
| Mm_RefseqmRNA = XM_001001421
| Mm_RefseqProtein = XP_001001421
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 19
| Mm_GenLoc_start = 39178942
| Mm_GenLoc_end = 39240067
| Mm_Uniprot =
}}
}}
'''Cytochrome P450, family 2, subfamily C, polypeptide 8''', also known as '''CYP2C8''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1558| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, benzo(a)pyrene, 7-ethyoxycoumarin, and the anti-cancer drug taxol. This gene is located within a cluster of cytochrome P450 genes on chromosome 10q24.<ref name="entrez">{{cite web | title = Entrez Gene: CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1558| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Goldstein JA, de Morais SM |title=Biochemistry and molecular biology of the human CYP2C subfamily. |journal=Pharmacogenetics |volume=4 |issue= 6 |pages= 285-99 |year= 1995 |pmid= 7704034 |doi= }}
*{{cite journal | author=Smith G, Stubbins MJ, Harries LW, Wolf CR |title=Molecular genetics of the human cytochrome P450 monooxygenase superfamily. |journal=Xenobiotica |volume=28 |issue= 12 |pages= 1129-65 |year= 1999 |pmid= 9890157 |doi= }}
*{{cite journal | author=García-Martín E, Martínez C, Ladero JM, Agúndez JA |title=Interethnic and intraethnic variability of CYP2C8 and CYP2C9 polymorphisms in healthy individuals. |journal=Molecular diagnosis & therapy |volume=10 |issue= 1 |pages= 29-40 |year= 2007 |pmid= 16646575 |doi= }}
*{{cite journal | author=Ged C, Beaune P |title=Isolation of the human cytochrome P-450 IIC8 gene: multiple glucocorticoid responsive elements in the 5' region. |journal=Biochim. Biophys. Acta |volume=1088 |issue= 3 |pages= 433-5 |year= 1991 |pmid= 1707679 |doi= }}
*{{cite journal | author=Romkes M, Faletto MB, Blaisdell JA, ''et al.'' |title=Cloning and expression of complementary DNAs for multiple members of the human cytochrome P450IIC subfamily. |journal=Biochemistry |volume=30 |issue= 13 |pages= 3247-55 |year= 1991 |pmid= 2009263 |doi= }}
*{{cite journal | author=Kolyada AY |title=Sequence of a human liver cytochrome P-450 cDNA clone. |journal=Nucleic Acids Res. |volume=18 |issue= 18 |pages= 5550 |year= 1990 |pmid= 2216732 |doi= }}
*{{cite journal | author=Shephard EA, Phillips IR, Santisteban I, ''et al.'' |title=Cloning, expression and chromosomal localization of a member of the human cytochrome P450IIC gene sub-family. |journal=Ann. Hum. Genet. |volume=53 |issue= Pt 1 |pages= 23-31 |year= 1989 |pmid= 2729895 |doi= }}
*{{cite journal | author=Ged C, Umbenhauer DR, Bellew TM, ''et al.'' |title=Characterization of cDNAs, mRNAs, and proteins related to human liver microsomal cytochrome P-450 (S)-mephenytoin 4'-hydroxylase. |journal=Biochemistry |volume=27 |issue= 18 |pages= 6929-40 |year= 1989 |pmid= 3196692 |doi= }}
*{{cite journal | author=Okino ST, Quattrochi LC, Pendurthi UR, ''et al.'' |title=Characterization of multiple human cytochrome P-450 1 cDNAs. The chromosomal localization of the gene and evidence for alternate RNA splicing. |journal=J. Biol. Chem. |volume=262 |issue= 33 |pages= 16072-9 |year= 1987 |pmid= 3500169 |doi= }}
*{{cite journal | author=Kimura S, Pastewka J, Gelboin HV, Gonzalez FJ |title=cDNA and amino acid sequences of two members of the human P450IIC gene subfamily. |journal=Nucleic Acids Res. |volume=15 |issue= 23 |pages= 10053-4 |year= 1988 |pmid= 3697070 |doi= }}
*{{cite journal | author=Zeldin DC, DuBois RN, Falck JR, Capdevila JH |title=Molecular cloning, expression and characterization of an endogenous human cytochrome P450 arachidonic acid epoxygenase isoform. |journal=Arch. Biochem. Biophys. |volume=322 |issue= 1 |pages= 76-86 |year= 1995 |pmid= 7574697 |doi= 10.1006/abbi.1995.1438 }}
*{{cite journal | author=Inoue K, Inazawa J, Suzuki Y, ''et al.'' |title=Fluorescence in situ hybridization analysis of chromosomal localization of three human cytochrome P450 2C genes (CYP2C8, 2C9, and 2C10) at 10q24.1. |journal=Jpn. J. Hum. Genet. |volume=39 |issue= 3 |pages= 337-43 |year= 1995 |pmid= 7841444 |doi= }}
*{{cite journal | author=Gray IC, Nobile C, Muresu R, ''et al.'' |title=A 2.4-megabase physical map spanning the CYP2C gene cluster on chromosome 10q24. |journal=Genomics |volume=28 |issue= 2 |pages= 328-32 |year= 1996 |pmid= 8530044 |doi= 10.1006/geno.1995.1149 }}
*{{cite journal | author=Wormhoudt LW, Ploemen JH, de Waziers I, ''et al.'' |title=Inter-individual variability in the oxidation of 1,2-dibromoethane: use of heterologously expressed human cytochrome P450 and human liver microsomes. |journal=Chem. Biol. Interact. |volume=101 |issue= 3 |pages= 175-92 |year= 1996 |pmid= 8870687 |doi= }}
*{{cite journal | author=McFayden MC, Melvin WT, Murray GI |title=Regional distribution of individual forms of cytochrome P450 mRNA in normal adult human brain. |journal=Biochem. Pharmacol. |volume=55 |issue= 6 |pages= 825-30 |year= 1998 |pmid= 9586955 |doi= }}
*{{cite journal | author=Macé K, Bowman ED, Vautravers P, ''et al.'' |title=Characterisation of xenobiotic-metabolising enzyme expression in human bronchial mucosa and peripheral lung tissues. |journal=Eur. J. Cancer |volume=34 |issue= 6 |pages= 914-20 |year= 1998 |pmid= 9797707 |doi= }}
*{{cite journal | author=Klose TS, Blaisdell JA, Goldstein JA |title=Gene structure of CYP2C8 and extrahepatic distribution of the human CYP2Cs. |journal=J. Biochem. Mol. Toxicol. |volume=13 |issue= 6 |pages= 289-95 |year= 1999 |pmid= 10487415 |doi= }}
*{{cite journal | author=Finta C, Zaphiropoulos PG |title=The human CYP2C locus: a prototype for intergenic and exon repetition splicing events. |journal=Genomics |volume=63 |issue= 3 |pages= 433-8 |year= 2000 |pmid= 10704292 |doi= 10.1006/geno.1999.6063 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on DAB2... {November 17, 2007 11:25:54 PM PST}
- SEARCH REDIRECT: Control Box Found: DAB2 {November 17, 2007 11:27:01 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 17, 2007 11:27:02 PM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {November 17, 2007 11:27:02 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 17, 2007 11:27:02 PM PST}
- UPDATED: Updated protein page: DAB2 {November 17, 2007 11:27:15 PM PST}
- INFO: Beginning work on DTNBP1... {November 17, 2007 11:40:55 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 17, 2007 11:41:40 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Dystrobrevin binding protein 1
| HGNCid = 17328
| Symbol = DTNBP1
| AltSymbols =; DBND; DKFZP564K192; FLJ30031; HPS7; MGC20210; My031; SDY
| OMIM = 607145
| ECnumber =
| Homologene = 12037
| MGIid = 2137586
| Function = {{GNF_GO|id=GO:0042802 |text = identical protein binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0016528 |text = sarcoplasm}} {{GNF_GO|id=GO:0030424 |text = axon}} {{GNF_GO|id=GO:0042383 |text = sarcolemma}}
| Process = {{GNF_GO|id=GO:0006996 |text = organelle organization and biogenesis}} {{GNF_GO|id=GO:0007601 |text = visual perception}} {{GNF_GO|id=GO:0050896 |text = response to stimulus}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 84062
| Hs_Ensembl = ENSG00000047579
| Hs_RefseqProtein = NP_115498
| Hs_RefseqmRNA = NM_032122
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 6
| Hs_GenLoc_start = 15631020
| Hs_GenLoc_end = 15771268
| Hs_Uniprot = Q96EV8
| Mm_EntrezGene = 94245
| Mm_Ensembl = ENSMUSG00000057531
| Mm_RefseqmRNA = NM_025772
| Mm_RefseqProtein = NP_080048
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 13
| Mm_GenLoc_start = 44933057
| Mm_GenLoc_end = 45013112
| Mm_Uniprot = Q91WZ8
}}
}}
'''Dystrobrevin binding protein 1''', also known as '''DTNBP1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: DTNBP1 dystrobrevin binding protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84062| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a protein that may play a role in organelle biogenesis associated with melanosomes, platelet dense granules, and lysosomes. A similar protein in mouse is a component of a protein complex termed biogenesis of lysosome-related organelles complex 1 (BLOC-1), and binds to alpha- and beta-dystrobrevins, which are components of the dystrophin-associated protein complex (DPC). Mutations in this gene are associated with Hermansky-Pudlak syndrome type 7. This gene may also be associated with schizophrenia. Multiple transcript variants encoding distinct isoforms have been identified for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: DTNBP1 dystrobrevin binding protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84062| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Huizing M, Boissy RE, Gahl WA |title=Hermansky-Pudlak syndrome: vesicle formation from yeast to man. |journal=Pigment Cell Res. |volume=15 |issue= 6 |pages= 405-19 |year= 2003 |pmid= 12453182 |doi= }}
*{{cite journal | author=Wiemann S, Weil B, Wellenreuther R, ''et al.'' |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422-35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701 }}
*{{cite journal | author=Benson MA, Newey SE, Martin-Rendon E, ''et al.'' |title=Dysbindin, a novel coiled-coil-containing protein that interacts with the dystrobrevins in muscle and brain. |journal=J. Biol. Chem. |volume=276 |issue= 26 |pages= 24232-41 |year= 2001 |pmid= 11316798 |doi= 10.1074/jbc.M010418200 }}
*{{cite journal | author=Straub RE, Jiang Y, MacLean CJ, ''et al.'' |title=Genetic variation in the 6p22.3 gene DTNBP1, the human ortholog of the mouse dysbindin gene, is associated with schizophrenia. |journal=Am. J. Hum. Genet. |volume=71 |issue= 2 |pages= 337-48 |year= 2002 |pmid= 12098102 |doi= }}
*{{cite journal | author=Moriyama K, Bonifacino JS |title=Pallidin is a component of a multi-protein complex involved in the biogenesis of lysosome-related organelles. |journal=Traffic |volume=3 |issue= 9 |pages= 666-77 |year= 2003 |pmid= 12191018 |doi= }}
*{{cite journal | author=Schwab SG, Knapp M, Mondabon S, ''et al.'' |title=Support for association of schizophrenia with genetic variation in the 6p22.3 gene, dysbindin, in sib-pair families with linkage and in an additional sample of triad families. |journal=Am. J. Hum. Genet. |volume=72 |issue= 1 |pages= 185-90 |year= 2003 |pmid= 12474144 |doi= }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Ciciotte SL, Gwynn B, Moriyama K, ''et al.'' |title=Cappuccino, a mouse model of Hermansky-Pudlak syndrome, encodes a novel protein that is part of the pallidin-muted complex (BLOC-1). |journal=Blood |volume=101 |issue= 11 |pages= 4402-7 |year= 2003 |pmid= 12576321 |doi= 10.1182/blood-2003-01-0020 }}
*{{cite journal | author=Morris DW, McGhee KA, Schwaiger S, ''et al.'' |title=No evidence for association of the dysbindin gene [DTNBP1] with schizophrenia in an Irish population-based study. |journal=Schizophr. Res. |volume=60 |issue= 2-3 |pages= 167-72 |year= 2003 |pmid= 12591580 |doi= }}
*{{cite journal | author=van den Oord EJ, Sullivan PF, Jiang Y, ''et al.'' |title=Identification of a high-risk haplotype for the dystrobrevin binding protein 1 (DTNBP1) gene in the Irish study of high-density schizophrenia families. |journal=Mol. Psychiatry |volume=8 |issue= 5 |pages= 499-510 |year= 2004 |pmid= 12808430 |doi= 10.1038/sj.mp.4001263 }}
*{{cite journal | author=Tang JX, Zhou J, Fan JB, ''et al.'' |title=Family-based association study of DTNBP1 in 6p22.3 and schizophrenia. |journal=Mol. Psychiatry |volume=8 |issue= 8 |pages= 717-8 |year= 2004 |pmid= 12888799 |doi= 10.1038/sj.mp.4001287 }}
*{{cite journal | author=Li W, Zhang Q, Oiso N, ''et al.'' |title=Hermansky-Pudlak syndrome type 7 (HPS-7) results from mutant dysbindin, a member of the biogenesis of lysosome-related organelles complex 1 (BLOC-1). |journal=Nat. Genet. |volume=35 |issue= 1 |pages= 84-9 |year= 2003 |pmid= 12923531 |doi= 10.1038/ng1229 }}
*{{cite journal | author=Mungall AJ, Palmer SA, Sims SK, ''et al.'' |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805-11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 }}
*{{cite journal | author=Van Den Bogaert A, Schumacher J, Schulze TG, ''et al.'' |title=The DTNBP1 (dysbindin) gene contributes to schizophrenia, depending on family history of the disease. |journal=Am. J. Hum. Genet. |volume=73 |issue= 6 |pages= 1438-43 |year= 2004 |pmid= 14618545 |doi= }}
*{{cite journal | author=Benson MA, Tinsley CL, Blake DJ |title=Myospryn is a novel binding partner for dysbindin in muscle. |journal=J. Biol. Chem. |volume=279 |issue= 11 |pages= 10450-8 |year= 2004 |pmid= 14688250 |doi= 10.1074/jbc.M312664200 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Williams NM, Preece A, Morris DW, ''et al.'' |title=Identification in 2 independent samples of a novel schizophrenia risk haplotype of the dystrobrevin binding protein gene (DTNBP1). |journal=Arch. Gen. Psychiatry |volume=61 |issue= 4 |pages= 336-44 |year= 2004 |pmid= 15066891 |doi= 10.1001/archpsyc.61.4.336 }}
*{{cite journal | author=Starcevic M, Dell'Angelica EC |title=Identification of snapin and three novel proteins (BLOS1, BLOS2, and BLOS3/reduced pigmentation) as subunits of biogenesis of lysosome-related organelles complex-1 (BLOC-1). |journal=J. Biol. Chem. |volume=279 |issue= 27 |pages= 28393-401 |year= 2004 |pmid= 15102850 |doi= 10.1074/jbc.M402513200 }}
*{{cite journal | author=Kirov G, Ivanov D, Williams NM, ''et al.'' |title=Strong evidence for association between the dystrobrevin binding protein 1 gene (DTNBP1) and schizophrenia in 488 parent-offspring trios from Bulgaria. |journal=Biol. Psychiatry |volume=55 |issue= 10 |pages= 971-5 |year= 2004 |pmid= 15121479 |doi= 10.1016/j.biopsych.2004.01.025 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on DYNLL1... {November 17, 2007 11:33:46 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 17, 2007 11:34:33 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_DYNLL1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1cmi.
| PDB = {{PDB2|1cmi}}, {{PDB2|1f3c}}, {{PDB2|1f95}}, {{PDB2|1f96}}, {{PDB2|1pwj}}, {{PDB2|1pwk}}, {{PDB2|1re6}}, {{PDB2|1rhw}}, {{PDB2|2pg1}}
| Name = Dynein, light chain, LC8-type 1
| HGNCid = 15476
| Symbol = DYNLL1
| AltSymbols =; DLC1; DLC8; DNCL1; DNCLC1; LC8; LC8a; MGC126137; MGC126138; PIN; hdlc1
| OMIM = 601562
| ECnumber =
| Homologene = 37844
| MGIid = 1861457
| GeneAtlas_image1 = PBB_GE_DYNLL1_200703_at_tn.png
| Function = {{GNF_GO|id=GO:0003777 |text = microtubule motor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005868 |text = cytoplasmic dynein complex}} {{GNF_GO|id=GO:0005874 |text = microtubule}}
| Process = {{GNF_GO|id=GO:0007017 |text = microtubule-based process}} {{GNF_GO|id=GO:0007292 |text = female gamete generation}} {{GNF_GO|id=GO:0009653 |text = anatomical structure morphogenesis}} {{GNF_GO|id=GO:0030036 |text = actin cytoskeleton organization and biogenesis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 8655
| Hs_Ensembl = ENSG00000088986
| Hs_RefseqProtein = NP_001032583
| Hs_RefseqmRNA = NM_001037494
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 12
| Hs_GenLoc_start = 119418309
| Hs_GenLoc_end = 119420679
| Hs_Uniprot = P63167
| Mm_EntrezGene = 56455
| Mm_Ensembl =
| Mm_RefseqmRNA = NM_019682
| Mm_RefseqProtein = NP_062656
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Dynein, light chain, LC8-type 1''', also known as '''DYNLL1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: DYNLL1 dynein, light chain, LC8-type 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8655| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Cytoplasmic dyneins are large enzyme complexes with a molecular mass of about 1,200 kD. They contain two force-producing heads formed primarily from dynein heavy chains, and stalks linking the heads to a basal domain, which contains a varying number of accessory intermediate chains. The complex is involved in intracellular transport and motility. The protein described in this record is a light chain and exists as part of this complex but also physically interacts with and inhibits the activity of neuronal nitric oxide synthase. Binding of this protein destabilizes the neuronal nitric oxide synthase dimer, a conformation necessary for activity, and it may regulate numerous biologic processes through its effects on nitric oxide synthase activity. Alternate transcriptional splice variants have been characterized.<ref name="entrez">{{cite web | title = Entrez Gene: DYNLL1 dynein, light chain, LC8-type 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8655| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, ''et al.'' |title=Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening. |journal=Genomics |volume=23 |issue= 1 |pages= 42-50 |year= 1995 |pmid= 7829101 |doi= 10.1006/geno.1994.1457 }}
*{{cite journal | author=Dick T, Ray K, Salz HK, Chia W |title=Cytoplasmic dynein (ddlc1) mutations cause morphogenetic defects and apoptotic cell death in Drosophila melanogaster. |journal=Mol. Cell. Biol. |volume=16 |issue= 5 |pages= 1966-77 |year= 1996 |pmid= 8628263 |doi= }}
*{{cite journal | author=Jaffrey SR, Snyder SH |title=PIN: an associated protein inhibitor of neuronal nitric oxide synthase. |journal=Science |volume=274 |issue= 5288 |pages= 774-7 |year= 1996 |pmid= 8864115 |doi= }}
*{{cite journal | author=Crépieux P, Kwon H, Leclerc N, ''et al.'' |title=I kappaB alpha physically interacts with a cytoskeleton-associated protein through its signal response domain. |journal=Mol. Cell. Biol. |volume=17 |issue= 12 |pages= 7375-85 |year= 1997 |pmid= 9372968 |doi= }}
*{{cite journal | author=Tochio H, Ohki S, Zhang Q, ''et al.'' |title=Solution structure of a protein inhibitor of neuronal nitric oxide synthase. |journal=Nat. Struct. Biol. |volume=5 |issue= 11 |pages= 965-9 |year= 1998 |pmid= 9808041 |doi= 10.1038/2940 }}
*{{cite journal | author=Rodríguez-Crespo I, Straub W, Gavilanes F, Ortiz de Montellano PR |title=Binding of dynein light chain (PIN) to neuronal nitric oxide synthase in the absence of inhibition. |journal=Arch. Biochem. Biophys. |volume=359 |issue= 2 |pages= 297-304 |year= 1998 |pmid= 9808772 |doi= }}
*{{cite journal | author=Fan JS, Zhang Q, Li M, ''et al.'' |title=Protein inhibitor of neuronal nitric-oxide synthase, PIN, binds to a 17-amino acid residue fragment of the enzyme. |journal=J. Biol. Chem. |volume=273 |issue= 50 |pages= 33472-81 |year= 1999 |pmid= 9837926 |doi= }}
*{{cite journal | author=Puthalakath H, Huang DC, O'Reilly LA, ''et al.'' |title=The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex. |journal=Mol. Cell |volume=3 |issue= 3 |pages= 287-96 |year= 1999 |pmid= 10198631 |doi= }}
*{{cite journal | author=Liang J, Jaffrey SR, Guo W, ''et al.'' |title=Structure of the PIN/LC8 dimer with a bound peptide. |journal=Nat. Struct. Biol. |volume=6 |issue= 8 |pages= 735-40 |year= 1999 |pmid= 10426949 |doi= 10.1038/11501 }}
*{{cite journal | author=Epstein E, Sela-Brown A, Ringel I, ''et al.'' |title=Dynein light chain binding to a 3'-untranslated sequence mediates parathyroid hormone mRNA association with microtubules. |journal=J. Clin. Invest. |volume=105 |issue= 4 |pages= 505-12 |year= 2000 |pmid= 10683380 |doi= }}
*{{cite journal | author=Naisbitt S, Valtschanoff J, Allison DW, ''et al.'' |title=Interaction of the postsynaptic density-95/guanylate kinase domain-associated protein complex with a light chain of myosin-V and dynein. |journal=J. Neurosci. |volume=20 |issue= 12 |pages= 4524-34 |year= 2000 |pmid= 10844022 |doi= }}
*{{cite journal | author=Jacob Y, Badrane H, Ceccaldi PE, Tordo N |title=Cytoplasmic dynein LC8 interacts with lyssavirus phosphoprotein. |journal=J. Virol. |volume=74 |issue= 21 |pages= 10217-22 |year= 2000 |pmid= 11024152 |doi= }}
*{{cite journal | author=Herzig RP, Andersson U, Scarpulla RC |title=Dynein light chain interacts with NRF-1 and EWG, structurally and functionally related transcription factors from humans and drosophila. |journal=J. Cell. Sci. |volume=113 Pt 23 |issue= |pages= 4263-73 |year= 2001 |pmid= 11069771 |doi= }}
*{{cite journal | author=Haraguchi K, Satoh K, Yanai H, ''et al.'' |title=The hDLG-associated protein DAP interacts with dynein light chain and neuronal nitric oxide synthase. |journal=Genes Cells |volume=5 |issue= 11 |pages= 905-911 |year= 2001 |pmid= 11122378 |doi= }}
*{{cite journal | author=Lo KW, Naisbitt S, Fan JS, ''et al.'' |title=The 8-kDa dynein light chain binds to its targets via a conserved (K/R)XTQT motif. |journal=J. Biol. Chem. |volume=276 |issue= 17 |pages= 14059-66 |year= 2001 |pmid= 11148209 |doi= 10.1074/jbc.M010320200 }}
*{{cite journal | author=Yano H, Lee FS, Kong H, ''et al.'' |title=Association of Trk neurotrophin receptors with components of the cytoplasmic dynein motor. |journal=J. Neurosci. |volume=21 |issue= 3 |pages= RC125 |year= 2001 |pmid= 11157096 |doi= }}
*{{cite journal | author=Fan J, Zhang Q, Tochio H, ''et al.'' |title=Structural basis of diverse sequence-dependent target recognition by the 8 kDa dynein light chain. |journal=J. Mol. Biol. |volume=306 |issue= 1 |pages= 97-108 |year= 2001 |pmid= 11178896 |doi= 10.1006/jmbi.2000.4374 }}
*{{cite journal | author=Bielli A, Thörnqvist PO, Hendrick AG, ''et al.'' |title=The small GTPase Rab4A interacts with the central region of cytoplasmic dynein light intermediate chain-1. |journal=Biochem. Biophys. Res. Commun. |volume=281 |issue= 5 |pages= 1141-53 |year= 2001 |pmid= 11243854 |doi= 10.1006/bbrc.2001.4468 }}
*{{cite journal | author=Yu J, Yu L, Chen Z, ''et al.'' |title=Protein inhibitor of neuronal nitric oxide synthase interacts with protein kinase A inhibitors. |journal=Brain Res. Mol. Brain Res. |volume=99 |issue= 2 |pages= 145-9 |year= 2002 |pmid= 11978406 |doi= }}
*{{cite journal | author=Fuhrmann JC, Kins S, Rostaing P, ''et al.'' |title=Gephyrin interacts with Dynein light chains 1 and 2, components of motor protein complexes. |journal=J. Neurosci. |volume=22 |issue= 13 |pages= 5393-402 |year= 2002 |pmid= 12097491 |doi= 20026552 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on DYRK1A... {November 17, 2007 11:27:15 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 17, 2007 11:28:36 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
| HGNCid = 3091
| Symbol = DYRK1A
| AltSymbols =; DYRK; DYRK1; HP86; MNB; MNBH
| OMIM = 600855
| ECnumber =
| Homologene = 55576
| MGIid = 1330299
| GeneAtlas_image1 = PBB_GE_DYRK1A_211079_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_DYRK1A_209033_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_DYRK1A_211541_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0004715 |text = non-membrane spanning protein tyrosine kinase activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016301 |text = kinase activity}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} {{GNF_GO|id=GO:0043621 |text = protein self-association}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0016607 |text = nuclear speck}}
| Process = {{GNF_GO|id=GO:0007399 |text = nervous system development}} {{GNF_GO|id=GO:0018108 |text = peptidyl-tyrosine phosphorylation}} {{GNF_GO|id=GO:0046777 |text = protein amino acid autophosphorylation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1859
| Hs_Ensembl = ENSG00000157540
| Hs_RefseqProtein = NP_001387
| Hs_RefseqmRNA = NM_001396
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 21
| Hs_GenLoc_start = 37713077
| Hs_GenLoc_end = 37809347
| Hs_Uniprot = Q13627
| Mm_EntrezGene = 13548
| Mm_Ensembl = ENSMUSG00000022897
| Mm_RefseqmRNA = NM_007890
| Mm_RefseqProtein = NP_031916
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 16
| Mm_GenLoc_start = 94720258
| Mm_GenLoc_end = 94801197
| Mm_Uniprot = Q61158
}}
}}
'''Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A''', also known as '''DYRK1A''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1859| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms.<ref name="entrez">{{cite web | title = Entrez Gene: DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1859| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Hämmerle B, Elizalde C, Galceran J, ''et al.'' |title=The MNB/DYRK1A protein kinase: neurobiological functions and Down syndrome implications. |journal=J. Neural Transm. Suppl. |volume= |issue= 67 |pages= 129-37 |year= 2004 |pmid= 15068245 |doi= }}
*{{cite journal | author=Galceran J, de Graaf K, Tejedor FJ, Becker W |title=The MNB/DYRK1A protein kinase: genetic and biochemical properties. |journal=J. Neural Transm. Suppl. |volume= |issue= 67 |pages= 139-48 |year= 2004 |pmid= 15068246 |doi= }}
*{{cite journal | author=Schultz SJ, Nigg EA |title=Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans. |journal=Cell Growth Differ. |volume=4 |issue= 10 |pages= 821-30 |year= 1994 |pmid= 8274451 |doi= }}
*{{cite journal | author=Shindoh N, Kudoh J, Maeda H, ''et al.'' |title=Cloning of a human homolog of the Drosophila minibrain/rat Dyrk gene from "the Down syndrome critical region" of chromosome 21. |journal=Biochem. Biophys. Res. Commun. |volume=225 |issue= 1 |pages= 92-9 |year= 1996 |pmid= 8769099 |doi= 10.1006/bbrc.1996.1135 }}
*{{cite journal | author=Guimerá J, Casas C, Pucharcòs C, ''et al.'' |title=A human homologue of Drosophila minibrain (MNB) is expressed in the neuronal regions affected in Down syndrome and maps to the critical region. |journal=Hum. Mol. Genet. |volume=5 |issue= 9 |pages= 1305-10 |year= 1997 |pmid= 8872470 |doi= }}
*{{cite journal | author=Song WJ, Sternberg LR, Kasten-Sportès C, ''et al.'' |title=Isolation of human and murine homologues of the Drosophila minibrain gene: human homologue maps to 21q22.2 in the Down syndrome "critical region". |journal=Genomics |volume=38 |issue= 3 |pages= 331-9 |year= 1997 |pmid= 8975710 |doi= 10.1006/geno.1996.0636 }}
*{{cite journal | author=Ohira M, Seki N, Nagase T, ''et al.'' |title=Gene identification in 1.6-Mb region of the Down syndrome region on chromosome 21. |journal=Genome Res. |volume=7 |issue= 1 |pages= 47-58 |year= 1997 |pmid= 9037601 |doi= }}
*{{cite journal | author=Chen H, Antonarakis SE |title=Localisation of a human homologue of the Drosophila mnb and rat Dyrk genes to chromosome 21q22.2. |journal=Hum. Genet. |volume=99 |issue= 2 |pages= 262-5 |year= 1997 |pmid= 9048932 |doi= }}
*{{cite journal | author=Smith DJ, Stevens ME, Sudanagunta SP, ''et al.'' |title=Functional screening of 2 Mb of human chromosome 21q22.2 in transgenic mice implicates minibrain in learning defects associated with Down syndrome. |journal=Nat. Genet. |volume=16 |issue= 1 |pages= 28-36 |year= 1997 |pmid= 9140392 |doi= 10.1038/ng0597-28 }}
*{{cite journal | author=Guimera J, Pritchard M, Nadal M, Estivill X |title=Minibrain (MNBH) is a single copy gene mapping to human chromosome 21q22.2. |journal=Cytogenet. Cell Genet. |volume=77 |issue= 3-4 |pages= 182-4 |year= 1997 |pmid= 9284911 |doi= }}
*{{cite journal | author=Dahmane N, Ghezala GA, Gosset P, ''et al.'' |title=Transcriptional map of the 2.5-Mb CBR-ERG region of chromosome 21 involved in Down syndrome. |journal=Genomics |volume=48 |issue= 1 |pages= 12-23 |year= 1998 |pmid= 9503011 |doi= 10.1006/geno.1997.5146 }}
*{{cite journal | author=Xu X, Rich ES, Seldin DC |title=Murine protein kinase CK2 alpha': cDNA and genomic cloning and chromosomal mapping. |journal=Genomics |volume=48 |issue= 1 |pages= 79-86 |year= 1998 |pmid= 9503019 |doi= 10.1006/geno.1997.5154 }}
*{{cite journal | author=Becker W, Weber Y, Wetzel K, ''et al.'' |title=Sequence characteristics, subcellular localization, and substrate specificity of DYRK-related kinases, a novel family of dual specificity protein kinases. |journal=J. Biol. Chem. |volume=273 |issue= 40 |pages= 25893-902 |year= 1998 |pmid= 9748265 |doi= }}
*{{cite journal | author=Wang J, Kudoh J, Shintani A, ''et al.'' |title=Identification of two novel 5' noncoding exons in human MNB/DYRK gene and alternatively spliced transcripts. |journal=Biochem. Biophys. Res. Commun. |volume=250 |issue= 3 |pages= 704-10 |year= 1998 |pmid= 9784410 |doi= 10.1006/bbrc.1998.9392 }}
*{{cite journal | author=Guimera J, Casas C, Estivill X, Pritchard M |title=Human minibrain homologue (MNBH/DYRK1): characterization, alternative splicing, differential tissue expression, and overexpression in Down syndrome. |journal=Genomics |volume=57 |issue= 3 |pages= 407-18 |year= 1999 |pmid= 10329007 |doi= 10.1006/geno.1999.5775 }}
*{{cite journal | author=Hattori M, Fujiyama A, Taylor TD, ''et al.'' |title=The DNA sequence of human chromosome 21. |journal=Nature |volume=405 |issue= 6784 |pages= 311-9 |year= 2000 |pmid= 10830953 |doi= 10.1038/35012518 }}
*{{cite journal | author=Woods YL, Rena G, Morrice N, ''et al.'' |title=The kinase DYRK1A phosphorylates the transcription factor FKHR at Ser329 in vitro, a novel in vivo phosphorylation site. |journal=Biochem. J. |volume=355 |issue= Pt 3 |pages= 597-607 |year= 2001 |pmid= 11311120 |doi= }}
*{{cite journal | author=Mao J, Maye P, Kogerman P, ''et al.'' |title=Regulation of Gli1 transcriptional activity in the nucleus by Dyrk1. |journal=J. Biol. Chem. |volume=277 |issue= 38 |pages= 35156-61 |year= 2002 |pmid= 12138125 |doi= 10.1074/jbc.M206743200 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Martí E, Altafaj X, Dierssen M, ''et al.'' |title=Dyrk1A expression pattern supports specific roles of this kinase in the adult central nervous system. |journal=Brain Res. |volume=964 |issue= 2 |pages= 250-63 |year= 2003 |pmid= 12576186 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on EBAG9... {November 17, 2007 11:36:33 PM PST}
- SEARCH REDIRECT: Control Box Found: EBAG9 {November 17, 2007 11:37:06 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 17, 2007 11:37:10 PM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {November 17, 2007 11:37:10 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 17, 2007 11:37:10 PM PST}
- UPDATED: Updated protein page: EBAG9 {November 17, 2007 11:37:17 PM PST}
- INFO: Beginning work on FCER1A... {November 17, 2007 11:28:37 PM PST}
- SEARCH REDIRECT: Control Box Found: FCER1A {November 17, 2007 11:29:19 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 17, 2007 11:29:20 PM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {November 17, 2007 11:29:20 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 17, 2007 11:29:20 PM PST}
- UPDATED: Updated protein page: FCER1A {November 17, 2007 11:29:27 PM PST}
- INFO: Beginning work on GABRG2... {November 17, 2007 11:29:27 PM PST}
- SEARCH REDIRECT: Control Box Found: GABRG2 {November 17, 2007 11:30:09 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 17, 2007 11:30:12 PM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {November 17, 2007 11:30:12 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 17, 2007 11:30:12 PM PST}
- UPDATED: Updated protein page: GABRG2 {November 17, 2007 11:30:20 PM PST}
- INFO: Beginning work on GATA2... {November 17, 2007 11:30:20 PM PST}
- SEARCH REDIRECT: Control Box Found: GATA2 {November 17, 2007 11:30:51 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 17, 2007 11:30:52 PM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {November 17, 2007 11:30:52 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 17, 2007 11:30:52 PM PST}
- UPDATED: Updated protein page: GATA2 {November 17, 2007 11:30:59 PM PST}
- INFO: Beginning work on GNA11... {November 17, 2007 11:30:59 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 17, 2007 11:31:27 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
| HGNCid = 4379
| Symbol = GNA11
| AltSymbols =; GNA-11
| OMIM = 139313
| ECnumber =
| Homologene = 20474
| MGIid = 95766
| GeneAtlas_image1 = PBB_GE_GNA11_564_at_tn.png
| GeneAtlas_image2 = PBB_GE_GNA11_40562_at_tn.png
| GeneAtlas_image3 = PBB_GE_GNA11_204248_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003774 |text = motor activity}} {{GNF_GO|id=GO:0003924 |text = GTPase activity}} {{GNF_GO|id=GO:0004871 |text = signal transducer activity}} {{GNF_GO|id=GO:0005525 |text = GTP binding}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0016459 |text = myosin complex}}
| Process = {{GNF_GO|id=GO:0001501 |text = skeletal development}} {{GNF_GO|id=GO:0001508 |text = regulation of action potential}} {{GNF_GO|id=GO:0006471 |text = protein amino acid ADP-ribosylation}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007507 |text = heart development}} {{GNF_GO|id=GO:0045634 |text = regulation of melanocyte differentiation}} {{GNF_GO|id=GO:0048066 |text = pigmentation during development}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2767
| Hs_Ensembl = ENSG00000088256
| Hs_RefseqProtein = NP_002058
| Hs_RefseqmRNA = NM_002067
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 19
| Hs_GenLoc_start = 3045408
| Hs_GenLoc_end = 3072452
| Hs_Uniprot = P29992
| Mm_EntrezGene = 14672
| Mm_Ensembl = ENSMUSG00000034781
| Mm_RefseqmRNA = NM_010301
| Mm_RefseqProtein = NP_034431
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 10
| Mm_GenLoc_start = 80931861
| Mm_GenLoc_end = 80948175
| Mm_Uniprot = Q3UPA1
}}
}}
'''Guanine nucleotide binding protein (G protein), alpha 11 (Gq class)''', also known as '''GNA11''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2767| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Wilkie TM, Gilbert DJ, Olsen AS, ''et al.'' |title=Evolution of the mammalian G protein alpha subunit multigene family. |journal=Nat. Genet. |volume=1 |issue= 2 |pages= 85-91 |year= 1993 |pmid= 1302014 |doi= 10.1038/ng0592-85 }}
*{{cite journal | author=Raymond JR, Mukhin YV, Gelasco A, ''et al.'' |title=Multiplicity of mechanisms of serotonin receptor signal transduction. |journal=Pharmacol. Ther. |volume=92 |issue= 2-3 |pages= 179-212 |year= 2002 |pmid= 11916537 |doi= }}
*{{cite journal | author=Jiang M, Pandey S, Tran VT, Fong HK |title=Guanine nucleotide-binding regulatory proteins in retinal pigment epithelial cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=88 |issue= 9 |pages= 3907-11 |year= 1991 |pmid= 1902575 |doi= }}
*{{cite journal | author=Thomas CP, Dunn MJ, Mattera R |title=Ca2+ signalling in K562 human erythroleukaemia cells: effect of dimethyl sulphoxide and role of G-proteins in thrombin- and thromboxane A2-activated pathways. |journal=Biochem. J. |volume=312 ( Pt 1) |issue= |pages= 151-8 |year= 1996 |pmid= 7492305 |doi= }}
*{{cite journal | author=Offermanns S, Simon MI |title=G alpha 15 and G alpha 16 couple a wide variety of receptors to phospholipase C. |journal=J. Biol. Chem. |volume=270 |issue= 25 |pages= 15175-80 |year= 1995 |pmid= 7797501 |doi= }}
*{{cite journal | author=Stanners J, Kabouridis PS, McGuire KL, Tsoukas CD |title=Interaction between G proteins and tyrosine kinases upon T cell receptor.CD3-mediated signaling. |journal=J. Biol. Chem. |volume=270 |issue= 51 |pages= 30635-42 |year= 1996 |pmid= 8530500 |doi= }}
*{{cite journal | author=Laugwitz KL, Allgeier A, Offermanns S, ''et al.'' |title=The human thyrotropin receptor: a heptahelical receptor capable of stimulating members of all four G protein families. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 1 |pages= 116-20 |year= 1996 |pmid= 8552586 |doi= }}
*{{cite journal | author=Launay JM, Birraux G, Bondoux D, ''et al.'' |title=Ras involvement in signal transduction by the serotonin 5-HT2B receptor. |journal=J. Biol. Chem. |volume=271 |issue= 6 |pages= 3141-7 |year= 1996 |pmid= 8621713 |doi= }}
*{{cite journal | author=Johnson GJ, Leis LA, Dunlop PC |title=Specificity of G alpha q and G alpha 11 gene expression in platelets and erythrocytes. Expressions of cellular differentiation and species differences. |journal=Biochem. J. |volume=318 ( Pt 3) |issue= |pages= 1023-31 |year= 1996 |pmid= 8836152 |doi= }}
*{{cite journal | author=Kinsella BT, O'Mahony DJ, Fitzgerald GA |title=The human thromboxane A2 receptor alpha isoform (TP alpha) functionally couples to the G proteins Gq and G11 in vivo and is activated by the isoprostane 8-epi prostaglandin F2 alpha. |journal=J. Pharmacol. Exp. Ther. |volume=281 |issue= 2 |pages= 957-64 |year= 1997 |pmid= 9152406 |doi= }}
*{{cite journal | author=Wise A, Parenti M, Milligan G |title=Interaction of the G-protein G11alpha with receptors and phosphoinositidase C: the contribution of G-protein palmitoylation and membrane association. |journal=FEBS Lett. |volume=407 |issue= 3 |pages= 257-60 |year= 1997 |pmid= 9175863 |doi= }}
*{{cite journal | author=Carrasco MP, Asbóth G, Phaneuf S, López Bernal A |title=Activation of the prostaglandin FP receptor in human granulosa cells. |journal=J. Reprod. Fertil. |volume=111 |issue= 2 |pages= 309-17 |year= 1998 |pmid= 9462300 |doi= }}
*{{cite journal | author=Qian A, Wang W, Sanborn BM |title=Evidence for the involvement of several intracellular domains in the coupling of oxytocin receptor to G alpha(q/11). |journal=Cell. Signal. |volume=10 |issue= 2 |pages= 101-5 |year= 1998 |pmid= 9481484 |doi= }}
*{{cite journal | author=Dulin NO, Sorokin A, Reed E, ''et al.'' |title=RGS3 inhibits G protein-mediated signaling via translocation to the membrane and binding to Galpha11. |journal=Mol. Cell. Biol. |volume=19 |issue= 1 |pages= 714-23 |year= 1999 |pmid= 9858594 |doi= }}
*{{cite journal | author=Hayes JS, Lawler OA, Walsh MT, Kinsella BT |title=The prostacyclin receptor is isoprenylated. Isoprenylation is required for efficient receptor-effector coupling. |journal=J. Biol. Chem. |volume=274 |issue= 34 |pages= 23707-18 |year= 1999 |pmid= 10446129 |doi= }}
*{{cite journal | author=Brydon L, Roka F, Petit L, ''et al.'' |title=Dual signaling of human Mel1a melatonin receptors via G(i2), G(i3), and G(q/11) proteins. |journal=Mol. Endocrinol. |volume=13 |issue= 12 |pages= 2025-38 |year= 2000 |pmid= 10598579 |doi= }}
*{{cite journal | author=Corbetta S, Mantovani G, Lania A, ''et al.'' |title=Calcium-sensing receptor expression and signalling in human parathyroid adenomas and primary hyperplasia. |journal=Clin. Endocrinol. (Oxf) |volume=52 |issue= 3 |pages= 339-48 |year= 2000 |pmid= 10718832 |doi= }}
*{{cite journal | author=Shraga-Levine Z, Sokolovsky M |title=Functional coupling of G proteins to endothelin receptors is ligand and receptor subtype specific. |journal=Cell. Mol. Neurobiol. |volume=20 |issue= 3 |pages= 305-17 |year= 2000 |pmid= 10789830 |doi= }}
*{{cite journal | author=AbdAlla S, Lother H, Abdel-tawab AM, Quitterer U |title=The angiotensin II AT2 receptor is an AT1 receptor antagonist. |journal=J. Biol. Chem. |volume=276 |issue= 43 |pages= 39721-6 |year= 2001 |pmid= 11507095 |doi= 10.1074/jbc.M105253200 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on ISG15... {November 17, 2007 11:39:46 PM PST}
- SEARCH REDIRECT: Control Box Found: ISG15 {November 17, 2007 11:40:15 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 17, 2007 11:40:16 PM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {November 17, 2007 11:40:16 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 17, 2007 11:40:16 PM PST}
- UPDATED: Updated protein page: ISG15 {November 17, 2007 11:40:23 PM PST}
- INFO: Beginning work on MAPK8IP1... {November 17, 2007 11:37:17 PM PST}
- SEARCH REDIRECT: Control Box Found: MAPK8IP1 {November 17, 2007 11:37:58 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 17, 2007 11:38:00 PM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {November 17, 2007 11:38:00 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 17, 2007 11:38:00 PM PST}
- UPDATED: Updated protein page: MAPK8IP1 {November 17, 2007 11:38:06 PM PST}
- INFO: Beginning work on PTGES... {November 17, 2007 11:38:47 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 17, 2007 11:39:46 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Prostaglandin E synthase
| HGNCid = 9599
| Symbol = PTGES
| AltSymbols =; MGC10317; MGST-IV; MGST1-L1; MGST1L1; PGES; PIG12; PP102; PP1294; TP53I12
| OMIM = 605172
| ECnumber =
| Homologene = 3587
| MGIid = 1927593
| GeneAtlas_image1 = PBB_GE_PTGES_210367_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_PTGES_207388_s_at_tn.png
| Function = {{GNF_GO|id=GO:0016853 |text = isomerase activity}} {{GNF_GO|id=GO:0050220 |text = prostaglandin-E synthase activity}}
| Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005641 |text = nuclear envelope lumen}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005792 |text = microsome}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006693 |text = prostaglandin metabolic process}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0019735 |text = antimicrobial humoral response}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 9536
| Hs_Ensembl = ENSG00000148344
| Hs_RefseqProtein = NP_004869
| Hs_RefseqmRNA = NM_004878
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 9
| Hs_GenLoc_start = 131540433
| Hs_GenLoc_end = 131555165
| Hs_Uniprot = O14684
| Mm_EntrezGene = 64292
| Mm_Ensembl = ENSMUSG00000050737
| Mm_RefseqmRNA = NM_022415
| Mm_RefseqProtein = NP_071860
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 2
| Mm_GenLoc_start = 30711480
| Mm_GenLoc_end = 30725306
| Mm_Uniprot = Q3UDM3
}}
}}
'''Prostaglandin E synthase''', also known as '''PTGES''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PTGES prostaglandin E synthase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9536| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a glutathione-dependent prostaglandin E synthase. The expression of this gene has been shown to be induced by proinflammatory cytokine interleukin 1 beta (IL1B). Its expression can also be induced by tumor suppressor protein TP53, and may be involved in TP53 induced apoptosis. Knockout studies in mice suggest that this gene may contribute to the pathogenesis of collagen-induced arthritis and mediate acute pain during inflammatory responses.<ref name="entrez">{{cite web | title = Entrez Gene: PTGES prostaglandin E synthase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9536| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Bastien L, Sawyer N, Grygorczyk R, ''et al.'' |title=Cloning, functional expression, and characterization of the human prostaglandin E2 receptor EP2 subtype. |journal=J. Biol. Chem. |volume=269 |issue= 16 |pages= 11873-7 |year= 1994 |pmid= 8163486 |doi= }}
*{{cite journal | author=Funk CD, Furci L, FitzGerald GA, ''et al.'' |title=Cloning and expression of a cDNA for the human prostaglandin E receptor EP1 subtype. |journal=J. Biol. Chem. |volume=268 |issue= 35 |pages= 26767-72 |year= 1994 |pmid= 8253813 |doi= }}
*{{cite journal | author=Polyak K, Xia Y, Zweier JL, ''et al.'' |title=A model for p53-induced apoptosis. |journal=Nature |volume=389 |issue= 6648 |pages= 300-5 |year= 1997 |pmid= 9305847 |doi= 10.1038/38525 }}
*{{cite journal | author=Giacomini E, Giordani L, di Modugno F, ''et al.'' |title=Increased PGE2 production mediates the in vitro inhibitory effect of the human immunodeficiency virus P24 immunosuppressive heptapeptide Ch7. |journal=Scand. J. Immunol. |volume=48 |issue= 3 |pages= 248-53 |year= 1998 |pmid= 9743208 |doi= }}
*{{cite journal | author=Jakobsson PJ, Morgenstern R, Mancini J, ''et al.'' |title=Common structural features of MAPEG -- a widespread superfamily of membrane associated proteins with highly divergent functions in eicosanoid and glutathione metabolism. |journal=Protein Sci. |volume=8 |issue= 3 |pages= 689-92 |year= 1999 |pmid= 10091672 |doi= }}
*{{cite journal | author=Jakobsson PJ, Thorén S, Morgenstern R, Samuelsson B |title=Identification of human prostaglandin E synthase: a microsomal, glutathione-dependent, inducible enzyme, constituting a potential novel drug target. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 13 |pages= 7220-5 |year= 1999 |pmid= 10377395 |doi= }}
*{{cite journal | author=Forsberg L, Leeb L, Thorén S, ''et al.'' |title=Human glutathione dependent prostaglandin E synthase: gene structure and regulation. |journal=FEBS Lett. |volume=471 |issue= 1 |pages= 78-82 |year= 2000 |pmid= 10760517 |doi= }}
*{{cite journal | author=Han R, Smith TJ |title=Cytoplasmic prostaglandin E2 synthase is dominantly expressed in cultured KAT-50 thyrocytes, cells that express constitutive prostaglandin-endoperoxide H synthase-2. Basis for low protaglandin E2 production. |journal=J. Biol. Chem. |volume=277 |issue= 39 |pages= 36897-903 |year= 2002 |pmid= 12145315 |doi= 10.1074/jbc.M206949200 }}
*{{cite journal | author=Giannoulias D, Alfaidy N, Holloway AC, ''et al.'' |title=Expression of prostaglandin I(2) synthase, but not prostaglandin E synthase, changes in myometrium of women at term pregnancy. |journal=J. Clin. Endocrinol. Metab. |volume=87 |issue= 11 |pages= 5274-82 |year= 2002 |pmid= 12414902 |doi= }}
*{{cite journal | author=Ouellet M, Falgueyret JP, Ear PH, ''et al.'' |title=Purification and characterization of recombinant microsomal prostaglandin E synthase-1. |journal=Protein Expr. Purif. |volume=26 |issue= 3 |pages= 489-95 |year= 2003 |pmid= 12460774 |doi= }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Uracz W, Uracz D, Olszanecki R, Gryglewski RJ |title=Interleukin 1beta induces functional prostaglandin E synthase in cultured human umbilical vein endothelial cells. |journal=J. Physiol. Pharmacol. |volume=53 |issue= 4 Pt 1 |pages= 643-54 |year= 2003 |pmid= 12512699 |doi= }}
*{{cite journal | author=Meadows JW, Eis AL, Brockman DE, Myatt L |title=Expression and localization of prostaglandin E synthase isoforms in human fetal membranes in term and preterm labor. |journal=J. Clin. Endocrinol. Metab. |volume=88 |issue= 1 |pages= 433-9 |year= 2003 |pmid= 12519887 |doi= }}
*{{cite journal | author=Kamei D, Murakami M, Nakatani Y, ''et al.'' |title=Potential role of microsomal prostaglandin E synthase-1 in tumorigenesis. |journal=J. Biol. Chem. |volume=278 |issue= 21 |pages= 19396-405 |year= 2003 |pmid= 12626523 |doi= 10.1074/jbc.M213290200 }}
*{{cite journal | author=Jakobsson PJ, Thorén S, Morgenstern R, Samuelsson B |title=Characterization of microsomal, glutathione dependent prostaglandin E synthase. |journal=Adv. Exp. Med. Biol. |volume=507 |issue= |pages= 287-91 |year= 2003 |pmid= 12664599 |doi= }}
*{{cite journal | author=Thorén S, Weinander R, Saha S, ''et al.'' |title=Human microsomal prostaglandin E synthase-1: purification, functional characterization, and projection structure determination. |journal=J. Biol. Chem. |volume=278 |issue= 25 |pages= 22199-209 |year= 2003 |pmid= 12672824 |doi= 10.1074/jbc.M303227200 }}
*{{cite journal | author=Alfaidy N, Sun M, Challis JR, Gibb W |title=Expression of membrane prostaglandin E synthase in human placenta and fetal membranes and effect of labor. |journal=Endocrine |volume=20 |issue= 3 |pages= 219-25 |year= 2003 |pmid= 12721500 |doi= }}
*{{cite journal | author=Ekström L, Lyrenäs L, Jakobsson PJ, ''et al.'' |title=Basal expression of the human MAPEG members microsomal glutathione transferase 1 and prostaglandin E synthase genes is mediated by Sp1 and Sp3. |journal=Biochim. Biophys. Acta |volume=1627 |issue= 2-3 |pages= 79-84 |year= 2003 |pmid= 12818425 |doi= }}
*{{cite journal | author=Murakami M, Nakashima K, Kamei D, ''et al.'' |title=Cellular prostaglandin E2 production by membrane-bound prostaglandin E synthase-2 via both cyclooxygenases-1 and -2. |journal=J. Biol. Chem. |volume=278 |issue= 39 |pages= 37937-47 |year= 2003 |pmid= 12835322 |doi= 10.1074/jbc.M305108200 }}
*{{cite journal | author=Trebino CE, Stock JL, Gibbons CP, ''et al.'' |title=Impaired inflammatory and pain responses in mice lacking an inducible prostaglandin E synthase. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 15 |pages= 9044-9 |year= 2003 |pmid= 12835414 |doi= 10.1073/pnas.1332766100 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on RIPK2... {November 17, 2007 11:34:33 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 17, 2007 11:35:10 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Receptor-interacting serine-threonine kinase 2
| HGNCid = 10020
| Symbol = RIPK2
| AltSymbols =; CCK; CARD3; CARDIAK; GIG30; RICK; RIP2
| OMIM = 603455
| ECnumber =
| Homologene = 37856
| MGIid = 1891456
| GeneAtlas_image1 = PBB_GE_RIPK2_209544_at_tn.png
| GeneAtlas_image2 = PBB_GE_RIPK2_209545_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004672 |text = protein kinase activity}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0004871 |text = signal transducer activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} {{GNF_GO|id=GO:0030274 |text = LIM domain binding}} {{GNF_GO|id=GO:0050700 |text = CARD domain binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}}
| Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0006954 |text = inflammatory response}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0043065 |text = positive regulation of apoptosis}} {{GNF_GO|id=GO:0043123 |text = positive regulation of I-kappaB kinase/NF-kappaB cascade}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 8767
| Hs_Ensembl = ENSG00000104312
| Hs_RefseqProtein = NP_003812
| Hs_RefseqmRNA = NM_003821
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 8
| Hs_GenLoc_start = 90839173
| Hs_GenLoc_end = 90872432
| Hs_Uniprot = O43353
| Mm_EntrezGene = 192656
| Mm_Ensembl = ENSMUSG00000041135
| Mm_RefseqmRNA = NM_138952
| Mm_RefseqProtein = NP_620402
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 4
| Mm_GenLoc_start = 16049889
| Mm_GenLoc_end = 16090790
| Mm_Uniprot = A1A4B5
}}
}}
'''Receptor-interacting serine-threonine kinase 2''', also known as '''RIPK2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RIPK2 receptor-interacting serine-threonine kinase 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8767| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein contains a C-terminal caspase activation and recruitment domain (CARD), and is a component of signaling complexes in both the innate and adaptive immune pathways. It is a potent activator of NF-kappaB and inducer of apoptosis in response to various stimuli.<ref name="entrez">{{cite web | title = Entrez Gene: RIPK2 receptor-interacting serine-threonine kinase 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8767| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Medzhitov R, Janeway C |title=Innate immune recognition: mechanisms and pathways. |journal=Immunol. Rev. |volume=173 |issue= |pages= 89-97 |year= 2000 |pmid= 10719670 |doi= }}
*{{cite journal | author=Dufner A, Mak TW |title=CARD tricks: controlling the interactions of CARD6 with RICK and microtubules. |journal=Cell Cycle |volume=5 |issue= 8 |pages= 797-800 |year= 2006 |pmid= 16582588 |doi= }}
*{{cite journal | author=Inohara N, del Peso L, Koseki T, ''et al.'' |title=RICK, a novel protein kinase containing a caspase recruitment domain, interacts with CLARP and regulates CD95-mediated apoptosis. |journal=J. Biol. Chem. |volume=273 |issue= 20 |pages= 12296-300 |year= 1998 |pmid= 9575181 |doi= }}
*{{cite journal | author=McCarthy JV, Ni J, Dixit VM |title=RIP2 is a novel NF-kappaB-activating and cell death-inducing kinase. |journal=J. Biol. Chem. |volume=273 |issue= 27 |pages= 16968-75 |year= 1998 |pmid= 9642260 |doi= }}
*{{cite journal | author=Thome M, Hofmann K, Burns K, ''et al.'' |title=Identification of CARDIAK, a RIP-like kinase that associates with caspase-1. |journal=Curr. Biol. |volume=8 |issue= 15 |pages= 885-8 |year= 1998 |pmid= 9705938 |doi= }}
*{{cite journal | author=Bertin J, Nir WJ, Fischer CM, ''et al.'' |title=Human CARD4 protein is a novel CED-4/Apaf-1 cell death family member that activates NF-kappaB. |journal=J. Biol. Chem. |volume=274 |issue= 19 |pages= 12955-8 |year= 1999 |pmid= 10224040 |doi= }}
*{{cite journal | author=Inohara N, Koseki T, del Peso L, ''et al.'' |title=Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-kappaB. |journal=J. Biol. Chem. |volume=274 |issue= 21 |pages= 14560-7 |year= 1999 |pmid= 10329646 |doi= }}
*{{cite journal | author=Navas TA, Baldwin DT, Stewart TA |title=RIP2 is a Raf1-activated mitogen-activated protein kinase kinase. |journal=J. Biol. Chem. |volume=274 |issue= 47 |pages= 33684-90 |year= 1999 |pmid= 10559258 |doi= }}
*{{cite journal | author=Inohara N, Koseki T, Lin J, ''et al.'' |title=An induced proximity model for NF-kappa B activation in the Nod1/RICK and RIP signaling pathways. |journal=J. Biol. Chem. |volume=275 |issue= 36 |pages= 27823-31 |year= 2000 |pmid= 10880512 |doi= 10.1074/jbc.M003415200 }}
*{{cite journal | author=Ogura Y, Inohara N, Benito A, ''et al.'' |title=Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB. |journal=J. Biol. Chem. |volume=276 |issue= 7 |pages= 4812-8 |year= 2001 |pmid= 11087742 |doi= 10.1074/jbc.M008072200 }}
*{{cite journal | author=Lee SH, Stehlik C, Reed JC |title=Cop, a caspase recruitment domain-containing protein and inhibitor of caspase-1 activation processing. |journal=J. Biol. Chem. |volume=276 |issue= 37 |pages= 34495-500 |year= 2001 |pmid= 11432859 |doi= 10.1074/jbc.M101415200 }}
*{{cite journal | author=Khursigara G, Bertin J, Yano H, ''et al.'' |title=A prosurvival function for the p75 receptor death domain mediated via the caspase recruitment domain receptor-interacting protein 2. |journal=J. Neurosci. |volume=21 |issue= 16 |pages= 5854-63 |year= 2001 |pmid= 11487608 |doi= }}
*{{cite journal | author=Druilhe A, Srinivasula SM, Razmara M, ''et al.'' |title=Regulation of IL-1beta generation by Pseudo-ICE and ICEBERG, two dominant negative caspase recruitment domain proteins. |journal=Cell Death Differ. |volume=8 |issue= 6 |pages= 649-57 |year= 2001 |pmid= 11536016 |doi= 10.1038/sj/cdd/4400881 }}
*{{cite journal | author=Chin AI, Dempsey PW, Bruhn K, ''et al.'' |title=Involvement of receptor-interacting protein 2 in innate and adaptive immune responses. |journal=Nature |volume=416 |issue= 6877 |pages= 190-4 |year= 2002 |pmid= 11894097 |doi= 10.1038/416190a }}
*{{cite journal | author=Kobayashi K, Inohara N, Hernandez LD, ''et al.'' |title=RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems. |journal=Nature |volume=416 |issue= 6877 |pages= 194-9 |year= 2002 |pmid= 11894098 |doi= 10.1038/416194a }}
*{{cite journal | author=Munz B, Hildt E, Springer ML, Blau HM |title=RIP2, a checkpoint in myogenic differentiation. |journal=Mol. Cell. Biol. |volume=22 |issue= 16 |pages= 5879-86 |year= 2002 |pmid= 12138198 |doi= }}
*{{cite journal | author=Yoo NJ, Park WS, Kim SY, ''et al.'' |title=Nod1, a CARD protein, enhances pro-interleukin-1beta processing through the interaction with pro-caspase-1. |journal=Biochem. Biophys. Res. Commun. |volume=299 |issue= 4 |pages= 652-8 |year= 2003 |pmid= 12459189 |doi= }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Chen YR, Clark AC |title=Equilibrium and kinetic folding of an alpha-helical Greek key protein domain: caspase recruitment domain (CARD) of RICK. |journal=Biochemistry |volume=42 |issue= 20 |pages= 6310-20 |year= 2003 |pmid= 12755636 |doi= 10.1021/bi0340752 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on SNAP23... {November 17, 2007 11:35:10 PM PST}
- SEARCH REDIRECT: Control Box Found: SNAP23 {November 17, 2007 11:35:46 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 17, 2007 11:35:47 PM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {November 17, 2007 11:35:47 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 17, 2007 11:35:47 PM PST}
- UPDATED: Updated protein page: SNAP23 {November 17, 2007 11:35:56 PM PST}
- INFO: Beginning work on UBTF... {November 17, 2007 11:31:28 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 17, 2007 11:32:19 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_UBTF_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1k99.
| PDB = {{PDB2|1k99}}, {{PDB2|1l8y}}, {{PDB2|1l8z}}, {{PDB2|1v63}}, {{PDB2|1v64}}, {{PDB2|1wgf}}
| Name = Upstream binding transcription factor, RNA polymerase I
| HGNCid = 12511
| Symbol = UBTF
| AltSymbols =; NOR-90; UBF
| OMIM = 600673
| ECnumber =
| Homologene = 7970
| MGIid = 98512
| GeneAtlas_image1 = PBB_GE_UBTF_202692_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_UBTF_214881_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003701 |text = RNA polymerase I transcription factor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005730 |text = nucleolus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006356 |text = regulation of transcription from RNA polymerase I promoter}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 7343
| Hs_Ensembl = ENSG00000108312
| Hs_RefseqProtein = NP_001070151
| Hs_RefseqmRNA = NM_001076683
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 17
| Hs_GenLoc_start = 39637928
| Hs_GenLoc_end = 39653762
| Hs_Uniprot = P17480
| Mm_EntrezGene = 21429
| Mm_Ensembl = ENSMUSG00000020923
| Mm_RefseqmRNA = NM_001044383
| Mm_RefseqProtein = NP_001037848
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 102122082
| Mm_GenLoc_end = 102135080
| Mm_Uniprot = Q05DS1
}}
}}
'''Upstream binding transcription factor, RNA polymerase I''', also known as '''UBTF''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: UBTF upstream binding transcription factor, RNA polymerase I| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7343| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Upstream binding factor (UBF) is a transcription factor required for expression of the 18S, 5.8S, and 28S ribosomal RNAs, along with SL1 (a complex of TBP (MIM 600075) and multiple TBP-associated factors or 'TAFs'). Two UBF polypeptides, of 94 and 97 kD, exist in the human (Bell et al., 1988). UBF is a nucleolar phosphoprotein with both DNA binding and transactivation domains. Sequence-specific DNA binding to the core and upstream control elements of the human rRNA promoter is mediated through several HMG boxes (Jantzen et al., 1990).[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: UBTF upstream binding transcription factor, RNA polymerase I| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7343| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Chan EK, Imai H, Hamel JC, Tan EM |title=Human autoantibody to RNA polymerase I transcription factor hUBF. Molecular identity of nucleolus organizer region autoantigen NOR-90 and ribosomal RNA transcription upstream binding factor. |journal=J. Exp. Med. |volume=174 |issue= 5 |pages= 1239-44 |year= 1991 |pmid= 1940801 |doi= }}
*{{cite journal | author=Jantzen HM, Admon A, Bell SP, Tjian R |title=Nucleolar transcription factor hUBF contains a DNA-binding motif with homology to HMG proteins. |journal=Nature |volume=344 |issue= 6269 |pages= 830-6 |year= 1990 |pmid= 2330041 |doi= 10.1038/344830a0 }}
*{{cite journal | author=Bell SP, Learned RM, Jantzen HM, Tjian R |title=Functional cooperativity between transcription factors UBF1 and SL1 mediates human ribosomal RNA synthesis. |journal=Science |volume=241 |issue= 4870 |pages= 1192-7 |year= 1988 |pmid= 3413483 |doi= }}
*{{cite journal | author=Voit R, Kuhn A, Sander EE, Grummt I |title=Activation of mammalian ribosomal gene transcription requires phosphorylation of the nucleolar transcription factor UBF. |journal=Nucleic Acids Res. |volume=23 |issue= 14 |pages= 2593-9 |year= 1995 |pmid= 7651819 |doi= }}
*{{cite journal | author=Hempel WM, Cavanaugh AH, Hannan RD, ''et al.'' |title=The species-specific RNA polymerase I transcription factor SL-1 binds to upstream binding factor. |journal=Mol. Cell. Biol. |volume=16 |issue= 2 |pages= 557-63 |year= 1996 |pmid= 8552083 |doi= }}
*{{cite journal | author=Hanada K, Song CZ, Yamamoto K, ''et al.'' |title=RNA polymerase I associated factor 53 binds to the nucleolar transcription factor UBF and functions in specific rDNA transcription. |journal=EMBO J. |volume=15 |issue= 9 |pages= 2217-26 |year= 1996 |pmid= 8641287 |doi= }}
*{{cite journal | author=Pluta AF, Earnshaw WC |title=Specific interaction between human kinetochore protein CENP-C and a nucleolar transcriptional regulator. |journal=J. Biol. Chem. |volume=271 |issue= 31 |pages= 18767-74 |year= 1996 |pmid= 8702533 |doi= }}
*{{cite journal | author=Matera AG, Wu W, Imai H, ''et al.'' |title=Molecular cloning of the RNA polymerase I transcription factor hUBF/NOR-90 (UBTF) gene and localization to 17q21.3 by fluorescence in situ hybridization and radiation hybrid mapping. |journal=Genomics |volume=41 |issue= 1 |pages= 135-8 |year= 1997 |pmid= 9126496 |doi= 10.1006/geno.1997.4647 }}
*{{cite journal | author=Whitehead CM, Winkfein RJ, Fritzler MJ, Rattner JB |title=ASE-1: a novel protein of the fibrillar centres of the nucleolus and nucleolus organizer region of mitotic chromosomes. |journal=Chromosoma |volume=106 |issue= 8 |pages= 493-502 |year= 1998 |pmid= 9426281 |doi= }}
*{{cite journal | author=Voit R, Hoffmann M, Grummt I |title=Phosphorylation by G1-specific cdk-cyclin complexes activates the nucleolar transcription factor UBF. |journal=EMBO J. |volume=18 |issue= 7 |pages= 1891-9 |year= 1999 |pmid= 10202152 |doi= 10.1093/emboj/18.7.1891 }}
*{{cite journal | author=Liu CJ, Wang H, Lengyel P |title=The interferon-inducible nucleolar p204 protein binds the ribosomal RNA-specific UBF1 transcription factor and inhibits ribosomal RNA transcription. |journal=EMBO J. |volume=18 |issue= 10 |pages= 2845-54 |year= 1999 |pmid= 10329630 |doi= 10.1093/emboj/18.10.2845 }}
*{{cite journal | author=Hannan KM, Hannan RD, Smith SD, ''et al.'' |title=Rb and p130 regulate RNA polymerase I transcription: Rb disrupts the interaction between UBF and SL-1. |journal=Oncogene |volume=19 |issue= 43 |pages= 4988-99 |year= 2000 |pmid= 11042686 |doi= 10.1038/sj.onc.1203875 }}
*{{cite journal | author=Kalousek I, Krízková P |title=Lymphocyte mitogenic transformation is accompanied by phosphorylation of the nucleolar transcription factor UBF. |journal=Cell. Mol. Biol. (Noisy-le-grand) |volume=46 |issue= 7 |pages= 1163-71 |year= 2001 |pmid= 11075946 |doi= }}
*{{cite journal | author=Pelletier G, Stefanovsky VY, Faubladier M, ''et al.'' |title=Competitive recruitment of CBP and Rb-HDAC regulates UBF acetylation and ribosomal transcription. |journal=Mol. Cell |volume=6 |issue= 5 |pages= 1059-66 |year= 2002 |pmid= 11106745 |doi= }}
*{{cite journal | author=Miller G, Panov KI, Friedrich JK, ''et al.'' |title=hRRN3 is essential in the SL1-mediated recruitment of RNA Polymerase I to rRNA gene promoters. |journal=EMBO J. |volume=20 |issue= 6 |pages= 1373-82 |year= 2001 |pmid= 11250903 |doi= 10.1093/emboj/20.6.1373 }}
*{{cite journal | author=Seither P, Iben S, Thiry M, Grummt I |title=PAF67, a novel protein that is associated with the initiation-competent form of RNA polymerase I. |journal=Biol. Chem. |volume=382 |issue= 8 |pages= 1163-70 |year= 2002 |pmid= 11592397 |doi= }}
*{{cite journal | author=Voit R, Grummt I |title=Phosphorylation of UBF at serine 388 is required for interaction with RNA polymerase I and activation of rDNA transcription. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 24 |pages= 13631-6 |year= 2002 |pmid= 11698641 |doi= 10.1073/pnas.231071698 }}
*{{cite journal | author=Stefanovsky VY, Pelletier G, Hannan R, ''et al.'' |title=An immediate response of ribosomal transcription to growth factor stimulation in mammals is mediated by ERK phosphorylation of UBF. |journal=Mol. Cell |volume=8 |issue= 5 |pages= 1063-73 |year= 2002 |pmid= 11741541 |doi= }}
*{{cite journal | author=Andersen JS, Lyon CE, Fox AH, ''et al.'' |title=Directed proteomic analysis of the human nucleolus. |journal=Curr. Biol. |volume=12 |issue= 1 |pages= 1-11 |year= 2002 |pmid= 11790298 |doi= }}
*{{cite journal | author=Dühr S, Torres-Montaner A, Astola A, ''et al.'' |title=Molecular analysis of the 5' region of human ribosomal transcription factor UBF. |journal=DNA Seq. |volume=12 |issue= 4 |pages= 267-72 |year= 2002 |pmid= 11916260 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on XBP1... {November 17, 2007 11:32:19 PM PST}
- SEARCH REDIRECT: Control Box Found: XBP1 {November 17, 2007 11:32:52 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 17, 2007 11:32:56 PM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {November 17, 2007 11:32:56 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 17, 2007 11:32:56 PM PST}
- UPDATED: Updated protein page: XBP1 {November 17, 2007 11:33:03 PM PST}
end log.
