WNT3

WNT3
Identifiers
Aliases	WNT3, INT4, TETAMS, Wnt family member 3
External IDs	OMIM: 165330 MGI: 98955 HomoloGene: 22527 GeneCards: WNT3
Gene location (Human)
Chr.	Chromosome 17 (human)
End	46,833,154 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	103,708,783 bp
RNA expression pattern
	Top expressed in
	skin of abdomen; ; hypothalamus; ; dorsolateral prefrontal cortex; ; substantia nigra; ; right lobe of liver; ; Brodmann area 9; ; prefrontal cortex; ; amygdala; ; superior frontal gyrus; ; nucleus accumbens;
	Top expressed in
	surface ectoderm; ; rhombic lip; ; lip; ; pretectal area; ; intestinal villus; ; enamel knot; ; cerebellar cortex; ; lateral habenular nucleus; ; medial habenular nucleus; ; mesoderm;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	receptor ligand activity; protein domain specific binding; frizzled binding; protein binding; signaling receptor binding;
Cellular component	cytoplasm; endocytic vesicle membrane; Wnt signalosome; endoplasmic reticulum lumen; plasma membrane; extracellular region; Golgi lumen; extracellular exosome; extracellular space; extracellular matrix;
Biological process	cellular response to retinoic acid; cell fate commitment; Spemann organizer formation at the anterior end of the primitive streak; head morphogenesis; limb bud formation; mammary gland epithelium development; anatomical structure formation involved in morphogenesis; mesoderm formation; positive regulation of collateral sprouting in absence of injury; negative regulation of axon extension involved in axon guidance; dorsal/ventral axis specification; axon guidance; limb development; multicellular organism development; positive regulation of Wnt signaling pathway; gamete generation; canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation; canonical Wnt signaling pathway involved in osteoblast differentiation; cell morphogenesis; canonical Wnt signaling pathway; anterior/posterior axis specification; embryonic forelimb morphogenesis; anterior/posterior pattern specification; embryonic hindlimb morphogenesis; Wnt signaling pathway; positive regulation of gene expression; regulation of neurogenesis; stem cell proliferation; canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation; canonical Wnt signaling pathway involved in stem cell proliferation; neuron differentiation; regulation of signaling receptor activity;
	Sources:Amigo / QuickGO
Orthologs
	7473
	22415
	ENSG00000108379; ENSG00000277641; ENSG00000277626
	ENSMUSG00000000125
	P56703
	P17553
	NM_030753
	NM_009521
	NP_110380
	NP_033547
	Wikidata
View/Edit Human	View/Edit Mouse

Proto-oncogene protein Wnt-3 is a protein that in humans is encoded by the WNT3 gene.^[5]^[6]

Template:PBB Summary

References

^ ^a ^b ^c ENSG00000277641, ENSG00000277626 GRCh38: Ensembl release 89: ENSG00000108379, ENSG00000277641, ENSG00000277626 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000000125 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Roelink H, Wang J, Black DM, Solomon E, Nusse R (Dec 1993). "Molecular cloning and chromosomal localization to 17q21 of the human WNT3 gene". Genomics. 17 (3): 790–2. doi:10.1006/geno.1993.1412. PMID 8244403.
^ "Entrez Gene: WNT3 wingless-type MMTV integration site family, member 3".

External links

GeneReviews/NIH/NCBI/UW entry on Tetra-Amelia Syndrome

v t e Signaling pathway: Wnt signaling pathway
Ligand	WNT1 WNT2 WNT2B WNT3 WNT3A WNT4 WNT5A WNT5B WNT6 WNT7A WNT7B WNT8A WNT8B WNT9A WNT9B WNT10A WNT10B WNT11 WNT16
Receptor	Frizzled LRP5 LRP6
Second messenger	Dishevelled GSK-3 APC Beta-catenin

References

External links

Further reading