Acute esophageal necrosis: Difference between revisions

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[[Acute esophageal necrosis]] (also known as '''Black Esophagus''', '''acute necrotizing esphagitis''',<ref name="pmid19159174">{{cite journal |author=Julián Gómez L, Barrio J, Atienza R, ''et al.'' |title=[Acute esophageal necrosis. An underdiagnosed disease] |language=Spanish; Castilian |journal=Rev Esp Enferm Dig |volume=100 |issue=11 |pages=701–5 |year=2008 |month=November |pmid=19159174 |doi=
[[Acute esophageal necrosis]] (Also known as '''Black Esophagus''', '''acute necrotizing esphagitis'''<ref>http://www.grupoaran.com/mrmUpdate/lecturaPDFfromXML.asp?IdArt=461047&TO=RVN&Eng=1</ref>, and '''esophageal infarction''') is a rare [[esophagus|esophageal]] disorder. It presents itself with a dark grey or black [[esophagus]] found during an upper gastrointestinal [[endoscopy]]<ref>http://www.springerlink.com/content/755043031406386r/</ref>. The disorder is extremely rare, as only 88 patients over a span of 40 years have received this diagnosis<ref>http://www.springerlink.com/content/755043031406386r/</ref>. Specific study of the disorder's mortality rate to 31.8%<ref>http://www.springerlink.com/content/755043031406386r/</ref>, but new research suggests mortality rates 50%+. The exact triggering mechanism for this disorder is still unknown, but is likely a multifactorial, but many cases have been linked with [[gastric outlet obstruction]] and [[malnutrition]], [[alcoholism]], as well as [[heart diseases]].<ref>http://www.grupoaran.com/mrmUpdate/lecturaPDFfromXML.asp?IdArt=461047&TO=RVN&Eng=1</ref>
|url=http://www.grupoaran.com/mrmUpdate/lecturaPDFfromXML.asp?IdArt=461047&TO=RVN&Eng=1}}</ref> and '''esophageal infarction''') is a rare [[esophagus|esophageal]] disorder. It presents itself with a dark grey or black [[esophagus]] found during an upper gastrointestinal [[endoscopy]].<ref name="pmid17322991">{{cite journal
|author=Gurvits GE, Shapsis A, Lau N, Gualtieri N, Robilotti JG |title=Acute esophageal necrosis: a rare syndrome |journal=J. Gastroenterol. |volume=42 |issue=1 |pages=29–38 |year=2007 |month=January |pmid=17322991 |doi=10.1007/s00535-006-1974-z
|url=}}</ref> The disorder is extremely rare, as only 88 patients over a span of 40 years have received this diagnosis.<ref name="pmid17322991"/> Specific study of the disorder's mortality rate to 31.8%,<ref name="pmid17322991"/> but new research suggests mortality rates 50%+. The exact triggering mechanism for this disorder is still unknown, but is likely a multifactorial, but many cases have been linked with [[gastric outlet obstruction]] and [[malnutrition]], [[alcoholism]], as well as [[heart diseases]].<ref name="pmid19159174" />


==Signs and Symptoms==
==Signs and symptoms==
Symptoms of [[Acute esophageal necrosis]] vary from the severity of the disorder. Common symptoms reported are [[coughing]], [[nausea]]. Left untreated, the coughing, normally [[phlegm]], may become [[Hemoptysis|hemotatic]]. As more cells become [[necrotic]]; more severe the nausea will become. Severe [[inflammation]] may reduce cause [[breathing]] difficulties.
Symptoms of acute esophageal necrosis vary from the severity of the disorder. Common symptoms reported are [[coughing]] and [[nausea]]. Left untreated, the coughing, normally [[phlegm]], may become [[Hemoptysis|bloody]]. As more cells become [[necrotic]], the nausea becomes more severe. Severe [[inflammation]] may reduce cause [[breathing]] difficulties.

===Symptoms===
*[[Upper gastrointestinal bleeding]]<ref name="pmid15285044">{{cite journal |author=Khan AM, Hundal R, Ramaswamy V, Korsten M, Dhuper S |title=Acute esophageal necrosis and liver pathology, a rare combination |journal=World J. Gastroenterol. |volume=10 |issue=16 |pages=2457–8 |year=2004 |month=August |pmid=15285044 |doi=
*[[Upper gastrointestinal bleeding]]<ref>http://www.wjgnet.com/1007-9327/10/2457.pdf</ref>
|url=}}</ref>
*[[Nausea]]
*[[Nausea]]
*[[Hemoptysis]]
*[[Hemoptysis]]
*[[Epigastralgia]]<ref>http://www.grupoaran.com/mrmUpdate/lecturaPDFfromXML.asp?IdArt=461047&TO=RVN&Eng=1</ref>
*[[Epigastralgia]]<ref name="pmid19159174" />
*[[Coughing]]
*[[Coughing]]
*[[Coffee ground vomiting]]<ref>http://www.grupoaran.com/mrmUpdate/lecturaPDFfromXML.asp?IdArt=461047&TO=RVN&Eng=1</ref>
*[[Coffee ground vomiting]]<ref name="pmid19159174" />
*[[Hematemesis]]<ref name="pmid19159174" />
*[[Hematemesis]]<ref>http://www.grupoaran.com/mrmUpdate/lecturaPDFfromXML.asp?IdArt=461047&TO=RVN&Eng=1</ref>


==Risk factors==
[[ageing|Elderly]] are the main targets for this disorder, and has a strong link. Almost all of the patients had either some [[heart disease]] or condition, or some sort of chronic [[alcoholism]].<ref name="pmid15285044" /> Other diseases, such as prolonged [[hypertension]],<ref name="pmid15285044" /> [[ischemia]],<ref name="pmid15285044" /> [[hyperglycemia]], hypersensitivity to [[antibiotics]],<ref name="pmid15285044" /> [[herpetic infection]],<ref name="pmid15285044" /> [[gastric volvulus]],<ref name="pmid15285044" /> posterior [[mediastinal]] [[haematoma]]<ref name="pmid15285044" /> and [[aortic dissection]],<ref name="pmid15285044" /> [[anti-cardiolipin antibodies]]<ref name="pmid15285044" /> and [[Steven Johnson syndrome]].<ref name="pmid15285044" />


==Risk Factors==
==In popular culture==
[[Acute esophageal necrosis]] made an appearance on an [[United States of America|American]] medical drama show, [[Dr. G: Medical Examiner]]. [[Jan Garavaglia]], the show's host, receives a female body, that at time of the autopsy had a severe case of [[acute esophageal necrosis]].
[[ageing|Elderly]] are the main targets for this disorder, and has a strong link. Almost all of the patients had either some [[heart disease]] or condition, or some sort of chronic [[alcoholism]]<ref>http://www.wjgnet.com/1007-9327/10/2457.pdf</ref>. Other diseases, such as prolonged [[hypertension]]<ref>http://www.wjgnet.com/1007-9327/10/2457.pdf</ref>, [[ischemia]]<ref>http://www.wjgnet.com/1007-9327/10/2457.pdf</ref>, [[hyperglycemia]], hypersensitivity to [[antibiotics]]<ref>http://www.wjgnet.com/1007-9327/10/2457.pdf</ref>, [[herpetic infection]]<ref>http://www.wjgnet.com/1007-9327/10/2457.pdf</ref>, [[gastric volvulus]]<ref>http://www.wjgnet.com/1007-9327/10/2457.pdf</ref>, posterior [[mediastinal]] [[haematoma]]<ref>http://www.wjgnet.com/1007-9327/10/2457.pdf</ref> and [[aortic dissection]]<ref>http://www.wjgnet.com/1007-9327/10/2457.pdf</ref>, [[anti-cardiolipin antibodies]]<ref>http://www.wjgnet.com/1007-9327/10/2457.pdf</ref> and [[Steven Johnson syndrome]]<ref>http://www.wjgnet.com/1007-9327/10/2457.pdf</ref>.



==Acute esophageal necrosis in popular culture==
[[Acute esophageal necrosis]] made an appearance on an [[United States of America|American]] medical drama show, [[Dr. G: Medical Examiner]]. [[Jan Garavaglia|Dr. Jan Garavaglia]], the show's host; receives a female body, that at time of the autopsy had a severe case of [[acute esophageal necrosis]].
==References==
==References==
{{reflist}}
{{reflist}}


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{{med-stub}}
{{Medicine}}
{{Medicine}}

Revision as of 19:17, 19 May 2009

Acute esophageal necrosis (also known as Black Esophagus, acute necrotizing esphagitis,[1] and esophageal infarction) is a rare esophageal disorder. It presents itself with a dark grey or black esophagus found during an upper gastrointestinal endoscopy.[2] The disorder is extremely rare, as only 88 patients over a span of 40 years have received this diagnosis.[2] Specific study of the disorder's mortality rate to 31.8%,[2] but new research suggests mortality rates 50%+. The exact triggering mechanism for this disorder is still unknown, but is likely a multifactorial, but many cases have been linked with gastric outlet obstruction and malnutrition, alcoholism, as well as heart diseases.[1]

Signs and symptoms

Symptoms of acute esophageal necrosis vary from the severity of the disorder. Common symptoms reported are coughing and nausea. Left untreated, the coughing, normally phlegm, may become bloody. As more cells become necrotic, the nausea becomes more severe. Severe inflammation may reduce cause breathing difficulties.

Risk factors

Elderly are the main targets for this disorder, and has a strong link. Almost all of the patients had either some heart disease or condition, or some sort of chronic alcoholism.[3] Other diseases, such as prolonged hypertension,[3] ischemia,[3] hyperglycemia, hypersensitivity to antibiotics,[3] herpetic infection,[3] gastric volvulus,[3] posterior mediastinal haematoma[3] and aortic dissection,[3] anti-cardiolipin antibodies[3] and Steven Johnson syndrome.[3]

In popular culture

Acute esophageal necrosis made an appearance on an American medical drama show, Dr. G: Medical Examiner. Jan Garavaglia, the show's host, receives a female body, that at time of the autopsy had a severe case of acute esophageal necrosis.

References

  1. ^ a b c d e Julián Gómez L, Barrio J, Atienza R; et al. (2008). "[Acute esophageal necrosis. An underdiagnosed disease]". Rev Esp Enferm Dig (in Spanish; Castilian). 100 (11): 701–5. PMID 19159174. {{cite journal}}: Explicit use of et al. in: |author= (help); Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link) CS1 maint: unrecognized language (link)
  2. ^ a b c Gurvits GE, Shapsis A, Lau N, Gualtieri N, Robilotti JG (2007). "Acute esophageal necrosis: a rare syndrome". J. Gastroenterol. 42 (1): 29–38. doi:10.1007/s00535-006-1974-z. PMID 17322991. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  3. ^ a b c d e f g h i j k Khan AM, Hundal R, Ramaswamy V, Korsten M, Dhuper S (2004). "Acute esophageal necrosis and liver pathology, a rare combination". World J. Gastroenterol. 10 (16): 2457–8. PMID 15285044. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)