After a tie against LSU to open the season, Alabama then defeated both Howard and Millsaps before they dueled Tennessee to a scoreless tie in the fourth week. The Crimson Tide then defeated Kentucky before they suffered their only regular season loss against Georgia. Alabama then closed the season with wins over both Ole Miss and Mississippi State and secured a position in the Sugar Bowl where they lost to Duke.
The 1944 squad marked the return of football at Alabama after a one-year hiatus for the 1943 season due to the effects of World War II. However as the war effort was ongoing at that time, the 1944 team was composed of players who were either too young and/or physically unable to enlist in the military. As the squad was generally smaller than both previous Alabama squads and than many they competed against, coach Thomas called this and the 1945 team the "War Babies."
In what marked the return of Alabama football for the first time since the 1942 season, the Crimson Tide met LSU for the first time since 1930 and left Baton Rouge with a 27–27 tie to open the season. LSU scored first on a 76-yard, Elwyn Rowan touchdown run in the first minute of play for a 7–0 Tigers' lead. Alabama tied the game at 7–7 by the end of the quarter when Lowell Tew scored on a two-yard run to cap a drive that started from the LSU ten-yard line after a Ray Coates fumble was recovered by James Pearl. The Tigers retook a 14–7 lead early in the second quarter when Y. A. Tittle threw a 34-yard touchdown pass to Dan Sandifer. However, the Crimson Tide responded with touchdown runs of 16-yards by Tew and 24-yards by Harry Gilmer for a 21–14 halftime lead.
The Tigers again tied the game in the third when Felix Trapani blocked a John Wade punt and returned it 26-yards for a touchdown. On the kickoff that ensued, Gilmer returned it 95-yards for a touchdown, for a 27–21 lead after a missed extra point by Hugh Morrow. Clyde Lindsey tied the game at 27 for LSU in the fourth after he both blocked and returned an Alabama kick, but Andrew Lay missed the extra point to make the final score 27–27. The tie brought Alabama's all-time record against LSU to 11–3–3.
In the first Legion Field game of the season, Alabama defeated Howard (now Samford University) 63–7 in a game that featured 49, second half points. After a scoreless first quarter, Lowell Tew scored both of the Alabama touchdowns in the second quarter on a 35-yard interception return and on a 21-yard touchdown run for a 14–0 halftime lead. The Crimson Tide then closed the game with four touchdowns in the third and three touchdowns in the fourth quarter. Third-quarter touchdowns were scored by Norwood Hodges and John Hite twice on runs and by Jim Rupich on a blocked punt recovery. Fourth-quarter touchdowns were scored on touchdown passes from George Albright to Lacey West (34 and 55-yards) and to Carlos Izaguirre (49-yards). The victory improved Alabama's all-time record against Howard to 20–0–1, and also marked the final game ever played between the respective schools on the football field.
In the first Denny Stadium game of the season, Alabama shutout the MillsapsMajors 55–0 in a game that featured 42, second half points. The Crimson Tide took a 13–0 halftime lead after touchdown runs of one-yard by Norwood Hodges in the first and four-yards by Jimmy Robertson in the second. They extended their lead to 34–0 at the end of the third with touchdowns scored on a one-yard Hal Self run, a six-yard Harry Gilmer run and on an 11-yard Hodges run. Alabama then concluded with three fourth-quarter touchdowns on a 12-yard Ed Podbielniak run, a short Self run and on a 19-yard John Hite run. The victory improved Alabama's all-time record against Millsaps to 3–0, and also marked the final game ever played between the respective schools on the football field.
Against the Volunteers, Alabama settled for a 0–0 tie before 32,000 fans at Shields-Watkins Field. In a game dominated by both defenses, Tennessee stopped Alabama drives three times from within their own 30-yard line in the fourth quarter to preserve the tie score. The tie brought Alabama's all-time record against Tennessee to 15–8–3.
At the Cramton Bowl, the Crimson Tide shutout the Wildcats 41–0 for their first conference victory of the season.Harry Gilmer scored the first touchdown for Alabama on a 41-yard run for a 7–0 lead after the first. In the second, Gilmer scored again on a short run and threw touchdown passes to George Albright and Hugh Morrow for a 27–0 halftime lead. John Hite was then responsible for the final two touchdowns of the game with his six-yard pass to Ralph Jones and his 41-yard interception return. The victory improved Alabama's all-time record against Kentucky 21–1–1.
After their victory over Kentucky, Alabama entered the weekly AP Poll for the first time during the season at the No. 19 position. Although the Crimson Tide led 7–0 at halftime, a pair of second half touchdowns gave the Bulldogs the 17–7 victory at Legion Field. Fred Grant scored the only Alabama points of the game with his five-yard touchdown run in the second quarter. Down by a touchdown, Charles Smith tied the game with his three-yard run in the third and Stan Nestorak scored the game-winning touchdown in the fourth with his three-yard run. The loss brought Alabama's all-time record against Georgia to 14–13–3.
In what was the first game played against Ole Miss since the 1933 season, Alabama defeated the Rebels 34–6 tie in Mobile. The Crimson Tide took control early with a three touchdown first quarter on a Fred Grant run, 48-yard Lowell Tew run and a short George Albright run. The Rebels' responded with their only points of the game in the second on a 29-yard Johnnie Bruce touchdown pass to Clyde Hooker to make the halftime score 21–6. After a scoreless third, a pair of fourth-quarter touchdowns were scored on runs by John Hite and Grant to make the final score 34–6. The victory improved Alabama's all-time record against Ole Miss 16–3–2.
On what was homecoming before the largest crowd to date at Denny Stadium, Alabama upset an undefeated Mississippi StateMaroons squad 19–0 in Tuscaloosa. After Harry Gilmer fumbled the opening kickoff to give the Maroons excellent field position, Fred Grant returned an interception 87-yards for a 7–0 lead. The other two Alabama touchdowns were scored on runs by Lowell Tew and Grant. The victory improved Alabama's all-time record against Mississippi State to 21–7–2.
On November 25, University officials announced that Alabama had accepted a bid to play in the 1945 Sugar Bowl against the DukeBlue Devils. In the game, the Crimson Tide were defeated 29–26 before 66,822 fans at Tulane Stadium after Duke score a late, game-winning touchdown. The Blue Devils took an early 7–0 on a 14-yard George Clark run before a pair of one-yard, Norwood Hodges touchdown runs gave the Crimson Tide a 12–7 lead at the end of the first. Alabama extended their lead further to 19–7 after Harry Gilmer threw a 12-yard touchdown pass to Ralph Jones. Duke responded with a pair of short, Tom Davis touchdown runs to take a 10–19 lead into the fourth quarter. In the fourth, Hugh Morrow had a touchdown on a 78-yard interception return; however, the Crimson Tide lost the game after Gilmer took a safety and George Clark scored the game-winning points on a 20-yard run.
On April 8, 1945, the National Football League held its ninth draft. In the draft, Johnny August was selected as the fifth pick in the eighth round (70th overall) by the Cleveland Rams, Jack Aland was selected as the fifth pick in the 13th round (125th overall) by the Cleveland Rams, Hal Self was selected as the second pick in the 14th round (133rd overall) by the Brooklyn Tigers, Bobby Tom Jenkins was selected as the sixth pick in the 17th round (170th overall) by the Washington Redskins, Jim McWhorter was selected as the sixth pick in the 18th round (181st overall) by the Detroit Lions, Norm Mosley was selected as the ninth pick in the 23rd round (239th overall) by the Philadelphia Eagles, Jack Green was selected as the sixth pick in the 25th round (258th overall) by the Chicago Bears, Charley Compton was selected as the fifth pick in the 30th round (312th overall) by the Cleveland Rams, Ken Reese was selected as the fourth pick in the 31st round (322nd overall) by the Philadelphia Eagles and John Staples was selected as the fifth pick in the 32nd round (329th overall) by the New York Giants.