Andropause

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Andropause also known as male menopause,[1] is the result of a gradual drop in testosterone which is an androgen. When men get into their early 30s, they begin losing testosterone at a rate of one to two percent a year. According to the U.S. Census Bureau, approximately 4-5 million men have symptoms of low testosterone levels.

The condition "andropause" is currently not recognized by the World Health Organization. When andropause occurs it's considered to be a deficiency state in which the hormone testosterone goes below the normal range for an aging male.

Andropause is caused by the reduction of hormones testosterone and dehydroepiandrosterone in middle-aged men. Testosterone assists the male body in building protein and is crucial for normal sexual drive and stamina. Testosterone also contributes to several metabolic functions including bone formation, and liver function. Adropause is also associated with a decrease in Leydig cells.[2] A steady decline in testosterone levels with age (in both men and women) is well documented.[3]

Symptoms[edit]

Symptoms that are caused by the reduction of male hormone testosterone are:[4]

  • Mood swings
  • Muscle loss[8]
  • Night sweats[8]
  • Weight gain

External causes[edit]

External factors that can[9] cause testosterone levels to fall include certain forms of medication, poor diet, excessive alcohol consumption, illness, lack of sleep, lack of sex, stress or surgery. It can also be a symptom of neuroendocrine dysfunction after a mild traumatic brain injury.[10]

Internal Causes[edit]

Andropause is preceded by a condition called Hypogonadotropic hypogonadism.[11] A downturn in the circulation of testosterone should cause the hypothalamus and pituitary gland to trigger a release of brain hormones that stimulate the testicles to ramp up production of testosterone.[12]

Although, as men age, despite low Testosterone, the levels of gonadotropin-releasing hormone (GnRH) and luteinizing hormone (LH) will not rise. The luteinizing hormone, gonadotropic releasing hormone, and testosterone all are dropping below what’s considered normal. Low GnRH, low LH, low testosterone indicate the syndrome of hypogonadotropic hypogonadism, and it is a downward trend that takes men closer to andropause. This phenomenon typically begins in the early forties.

Eventually, testosterone levels drop to such low levels, the hypothalamus and pituitary kick in and produce high levels of GnRH and LH to compensate. This triggers the production of testosterone, which will generally work for a while, but then will fall again. That’s when men enter andropause. They have a low testosterone and a high LH and GnRH, whereas before they had a low testosterone as well as low LH and GnRH.

This shift in hormonal patterns occurs in all men at some point. The female version, a similar hormonal shift that occurs in women happens in a more narrow age grouping, from early forties to late fifties.[13]

As a "state"[edit]

The impact of low levels of testosterone has been previously reported. In 1944, Heller and Myers[14] identified symptoms of what they labeled the "male climacteric" including loss of libido and potency, nervousness, depression, impaired memory, the inability to concentrate, fatigue, insomnia, hot flushes, and sweating. Heller and Myers found that their subjects had lower than normal levels of testosterone, and that symptoms decreased dramatically when patients were given replacement doses of testosterone.

Andropause has been observed in association also with Alzheimer's disease.[15]

In one study, 98.0% of primary care physicians believed that andropause and osteoporosis risk were related.[16]

The term "symptomatic late onset hypogonadism" (or "SLOH") is sometimes considered to refer to the same condition as the word "andropause".[17][18]

Some researchers prefer the term "androgen deficiency of the aging male" ("ADAM"), to more accurately reflect the fact that the loss of testosterone production is gradual and asymptotic[19] (in contrast to the more abrupt change associated with menopause.[20]) The "D" is sometimes given as "decline" instead of "deficiency". In some contexts, the term "partial androgen deficiency in aging males" ("PADAM") is used instead.[21]

As a disorder[edit]

Proponents[edit]

Proponents of andropause as a distinct condition claim that it is a biological change experienced by men during mid-life, and often compare it to female menopause. Menopause, however, is a complete cessation of reproductive ability caused by the shutting down of the female reproductive system. Andropause is a decline in the male hormone testosterone. This drop in testosterone levels is considered to lead to in some cases erectile dysfunction, diabetes, loss of energy and concentration, depression, and mood swings. While andropause does not cause a man's reproductive system to stop working altogether, many experience symptoms of it impotence.

"Age also significantly affects circulating testosterone concentrations. Until puberty, children do not experience an acute increase in testosterone from a bout of resistance exercise; after puberty some acute increases in testosterone from resistance exercise can be found in boys but not in girls. Aging beyond 35–40 years is associated with a 1–3% decline per year in circulating testosterone concentration in men."[22] The theory is that andropause is caused by a very gradual testosterone deficiency and an increase in sex hormone-binding globulin (SHBG) that occurs from age 40 onward. By contrast, women have a more rapid onset of menopause at an average age of 51. Testosterone declines 10% every decade after age 30 (1% per year).

What is known as premature andropause is theorized to occur in males who experience excessive female hormone stimulation through workplace exposure to estrogen. Men who work in the pharmaceutical industry, plastics factories, near incinerators, and on farms that use pesticides are high-risk for early andropause.[citation needed]

Proponents claim that by their mid-50s, about 30 percent of men experience andropause. It is thought that about 5 million American men do not produce adequate testosterone, which leads to early andropause. In Australia, about 1 in every 200 men under the age of 60 and about 1 in every 10 men over 60 have low testosterone. Regardless of location, the most likely males to develop early andropause are those with diabetes, hypertension, and genetic disorders that produce hypogonadism, including Klinefelter's, Wilson-Turner, and Androgen insensitivity syndromes.

Much of the current popular interest in the concept of andropause has been fueled by the book Male Menopause, written by Jed Diamond, a lay person.[23] According to Diamond's view, andropause is a change of life in middle-aged men, which has hormonal, physical, psychological, interpersonal, social, sexual, and spiritual aspects. Diamond claims that this change occurs in all men, generally between the ages of 40 and 55, though it can occur as early as 35 or as late as 65. The term "male menopause" may be a misnomer, as unlike women, men's reproductive systems do not cease to work completely in mid-life; some men continue to father children late into their lives (at age 90 or older[24]). But Diamond claims that, in terms of other life impacts, women’s and men’s experience are somewhat similar phenomena.[25][26][27]

The concept of andropause is perhaps more widely accepted in Australia and some parts of Europe than it is in the United States.[28]

Opponents[edit]

Many clinicians believe that andropause is not a valid concept. Men can continue to reproduce into old age; their reproductive systems do not stop working completely in midlife, and therefore they do not exhibit the sudden and dramatic drops in hormone levels characteristic of women going through menopause.

Other clinicians have the opinion that andropause is simply synonymous with hypogonadism or unusually low testosterone levels.[27] There is opposition to the concept of andropause in Europe as well as the U.S.[29]

Some clinicians argue that many of the cited symptoms are not specific enough to warrant describing a new condition. For example, people who are overweight may be misguided into treating a new illness rather than addressing the lifestyle that led to their being overweight. Similarly, energy levels vary from person to person, and for people who are generally inactive, energy levels will automatically be lower overall.

While it is true that active and otherwise healthy men could in theory develop andropause-like symptoms, how common and widespread the phenomenon is, and whether genetics, lifestyle, environment, or a combination of factors are responsible, is not yet known.

Hormone replacement therapy[edit]

Testosterone levels (T-levels) decline gradually as humans age. Unlike females going through menopause, the decline in testosterone in men is gradual, and there is variation among individuals.[30] After reaching 80 years of age, the rate of testosterone secretion decreases about 50% for men.[30]

The clinical significance of this decrease is debated. There is disagreement between doctors about when and how to treat men with decreasing T-levels. The American Society of Andrology's position states testosterone replacement therapy is recommended when both clinical symptoms and signs of androgen deficiency (male equivalent of menopause) and decreased testosterone levels are present in aging men.[31]

Experts said the study, published in the September 12, 2013 issue of the New England Journal of Medicine,[32] deepens researchers' understanding of the hormonal shifts that occur as men age. Additionally, The American Association of Clinical Endocrinologists defines hypogonadism as a testosterone level that is below the lower limit of normal for young adult control subjects[33] Previously, age-related decreases in free testosterone were once accepted as normal.[34] Currently, they are not considered normal. [35] Patients with borderline testosterone levels warrant a clinical trial of testosterone according to some endocrinologists in 2003.[36] Researchers are skeptical about the simplicity of ads about "low T" and testosterone supplements and their impact on men.[citation needed] Instead, researchers conclude there is no black-and-white cutoff for "low" or "suboptimal" testosterone. Different symptoms show up at different testosterone thresholds: Muscle mass and strength do not decline until testosterone drops quite low (significantly below normal levels) whereas libido may dampen with relatively small decreases in the hormone. [37] According to Joel Finkelstein, associate director of the Bone Density Center at Massachusetts General Hospital in Boston, men’s functioning is not impaired solely by a loss of testosterone, but by a loss of estrogen as well.[38]

Agreement on the threshold of testosterone values below which a man would be considered hypogonadal has not been reached (currently, there are no standards as to when to treat women). Testosterone can be measured as "free" (that is, bioavailable and unbound) or, more commonly, "total" (including the percentage that is chemically bound and unavailable). In the United States, male total testosterone levels below 300 ng/dl from a morning serum sample (most accurate measurement) are generally considered low.[citation needed] To confirm the low levels of testosterone, doctors recommend repeating the measurement of morning total testosterone.[citation needed] Identification of inadequate testosterone in an aging male by symptoms alone can be difficult, especially because many different factors can be involved.

Testosterone supplemental therapy is available in the form of topical gels, patches, and injections and can cost up to $300 a month.[39] Researchers at the Boston University School of Medicine, recommend testosterone therapy for men with androgen deficiencies who have low testosterone levels[40] Therapy allows men to maintain sex characteristics, which can improve their sexual function.[41] Testosterone supplemental therapy can also increase a sense of well being, muscle mass and strength, and bone density in men.[42]

Adverse effects[edit]

Adverse effects of testosterone supplementation may include increased cardiovascular events (including strokes and heart attacks) and deaths based on three peer-reviewed studies involving men taking FDA-approved testosterone-replacement.[43] In addition, an increase of 30% in deaths and heart attacks in older men has been reported.[44] Due to an increased incidence of adverse cardiovascular events compared to a placebo group, a Testosterone in Older Men with Mobility Limitations (TOM) trial (a National Institute of Aging randomized trial) was halted early by the Data Safety and Monitoring Committee.[45] On January 31, 2014, reports of strokes, heart attacks, and deaths in men taking FDA-approved testosterone-replacement led the Food and Drug Administration (FDA) to announce that it would be investigating the issue.[46] Later, in September 2014, the FDA announced, as a result of the "potential for adverse cardiovascular outcomes", a review of the appropriateness and safety of Testosterone Replacement Therapy (TRT).[47][48][49]

Other adverse effects of testosterone supplementation may include increased hematocrit (which may require venipuncture in order to treat), exacerbation of sleep apnea and acceleration of pre-existing prostate cancer growth in individuals having undergone androgen deprivation.[50] Adverse effects may also include minor side-effects such as acne and oily skin as well as significant hair loss and/or thinning of the hair which may be prevented with 5-alpha reductase inhibitors ordinarily used for the treatment of benign prostatic hyperplasia such as finasteride or dutasteride.[51]

Exogenous testosterone may also cause suppression of spermatogenesis, leading to, in some cases, infertility.[52] It is recommended that physicians screen for prostate cancer with a digital rectal exam and prostate-specific antigen (PSA) level before starting therapy, and monitor hematocrit and PSA levels closely during therapy.[53]

In popular culture[edit]

In the 154th episode of the animated television series King of the Hill ("The Incredible Hank"), Hank is diagnosed with irritable male syndrome, and is prescribed testosterone.[54]

In the 98th episode of the series "Yes, Dear" ("Jimmy Has Changed"), Jimmy is diagnosed with andropause after coming down with a case of the sweats and a decreased interest in sex.[55]

See also[edit]

References[edit]

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  55. ^ "Episode plot "Jimmy has changed"". IMDb. Retrieved 30 August 2014. 

External links[edit]