Gem-associated protein 6

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Gem (nuclear organelle) associated protein 6
Protein GEMIN6 PDB 1y96.png
PDB rendering based on 1y96.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols GEMIN6 ; FLJ23459
External IDs OMIM607006 MGI1914492 HomoloGene11711 GeneCards: GEMIN6 Gene
RNA expression pattern
PBB GE GEMIN6 219539 at tn.png
More reference expression data
Species Human Mouse
Entrez 79833 67242
Ensembl ENSG00000152147 ENSMUSG00000055760
UniProt Q8WXD5 Q9CX53
RefSeq (mRNA) NM_024775 NM_026053
RefSeq (protein) NP_079051 NP_080329
Location (UCSC) Chr 2:
38.98 – 39.01 Mb
Chr 17:
80.22 – 80.23 Mb
PubMed search [1] [2]

Gem-associated protein 6 is a protein that in humans is encoded by the GEMIN6 gene.[1][2]

GEMIN6 is part of a large macromolecular complex, localized to both the cytoplasm and the nucleus, that plays a role in the cytoplasmic assembly of small nuclear ribonucleoproteins (snRNPs). Other members of this complex include SMN (MIM 600354), GEMIN2 (SIP1; MIM 602595), GEMIN3 (DDX20; MIM 606168), GEMIN4 (MIM 606969), and GEMIN5 (MIM 607005).[supplied by OMIM][2]


Gem-associated protein 6 has been shown to interact with Gem-associated protein 7.[3][4]


  1. ^ Pellizzoni L, Baccon J, Rappsilber J, Mann M, Dreyfuss G (Feb 2002). "Purification of native survival of motor neurons complexes and identification of Gemin6 as a novel component". J Biol Chem 277 (9): 7540–5. doi:10.1074/jbc.M110141200. PMID 11748230. 
  2. ^ a b "Entrez Gene: GEMIN6 gem (nuclear organelle) associated protein 6". 
  3. ^ Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  4. ^ Baccon, Jennifer; Pellizzoni Livio; Rappsilber Juri; Mann Matthias; Dreyfuss Gideon (Aug 2002). "Identification and characterization of Gemin7, a novel component of the survival of motor neuron complex". J. Biol. Chem. (United States) 277 (35): 31957–62. doi:10.1074/jbc.M203478200. ISSN 0021-9258. PMID 12065586. 

Further reading[edit]