Jeunet and Caro's first feature film was Delicatessen (1991), a melancholy comedy set in a famine-plagued post-apocalyptic world, in which an apartment building above a delicatessen is ruled by a butcher who kills people in order to feed his tenants.
The success of The City of Lost Children led to an invitation to direct the fourth movie in the Alien series, Alien Resurrection (1997). Jeunet directed Amélie, starring Audrey Tautou.Amélie was happier in tone than his earlier films and added romantic and comedic elements. This story, about a woman who takes pleasure in doing good deeds but has trouble finding love herself, was a huge critical and commercial success worldwide and was nominated for several Academy Awards. For this film, Jeunet also gained a European Film Award for Best Director.
Jeunet has also directed numerous commercials including a 2'25" film for Chanel N° 5 featuring his frequent collaborator Audrey Tautou.
According to the official site for Jeunet, financing is in place for his next project: TS Spivet, the adaptation of Reif Larsen’s book: The Selected Works of T.S. Spivet. The film is to be shot in English on location in Canada and the US in 3D for a release in 2013.