Oncocytoma
From Wikipedia, the free encyclopedia
| Oncocytoma | |
| Classification and external resources | |
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|---|---|
| Micrograph of a renal oncocytoma. H&E stain. | |
| ICD-O: | M8290/0 |
| DiseasesDB | 31956 |
| eMedicine | med/1045 |
| MeSH | D018249 |
An oncocytoma is a tumor made up of oncocytes, a special kind of cells. [1] [2]
Contents |
[edit] Presentation
An oncocytoma is an epithelial tumor composed of oncocytes, large eosinophilic cells having small, round, benign-appearing nuclei with large nucleoli.
Oncocytoma can arise in a number of organs.
[edit] Renal oncocytoma
[edit] Salivary gland oncocytoma
The salivary gland oncocytoma is a well-circumscribed, benign neoplastic growth also called an oxyphilic adenoma. It comprises about 1% of all salivary gland tumors. The histopathology is marked by sheets of large swollen polyhedral epithelial oncocytes, which are granular acidophilic parotid cells with centrally located nuclei. The granules are created by the mitochondria.
[edit] Symptoms
Salivary gland oncocytomas are most common in ages 70-80, females, the parotid gland (85-90%), and are firm, slowly growing, painless masses of < 4 cm. They may be bilateral.
[edit] Thyroid oncocytoma
Thyroid oncocytomas can be benign (adenomas) or malignant (carcinomas). Grossly, oncocytic adenomas are encapsulated, solid nodules with a characteristic brown cut surface. The gross appearance of a minimally invasive oncocytic carcinoma is indistinguishable to that of an adenoma, while widely invasive oncocytic carcinomas are obviously invasive macroscopically and display pervasive vascular invasion with multifocal involvement of the thyroid gland. There are no reliable cytologic features which distinguish oncocytic adenomas from carcinomas and the only criteria for a diagnosis of malignancy is the identification of transcapsular and/or vascular invasion.
[edit] Symptoms
Patients with thyroid oncocytomas present with a thyroid nodule, usually with normal thyroid function. If the tumor is big or invasive, there may be other symptoms such as difficulty swallowing or talking.
[edit] See also
[edit] Additional images
 Micrograph of a renal oncocytoma. H&E stain. |
 Micrograph of a renal oncocytoma. H&E stain. |
[edit] References
- ^ Coburn V, Radfar A, Snook D, Mahalingam M (2007). "Cutaneous oncocytoma - a report of three cases and review of the literature". J. Cutan. Pathol. 34 (4): 355–9. doi:. PMID 17381809. http://www.blackwell-synergy.com/openurl?genre=article&sid=nlm:pubmed&issn=0303-6987&date=2007&volume=34&issue=4&spage=355.
- ^ "Atlas of Genetics and Cytogenetics in Oncology and Haematology - Thyroid:oncocytic tumors". http://atlasgeneticsoncology.org/Tumors/OncocytThyroidID5068.html. Retrieved on 2009-02-01.
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