During the season, the car turned out to be slower than the McLaren MP4-20 at numerous points, with the win tally being 8-10. Reliability and consistency prevailed in the end, with Fernando Alonso and Giancarlo Fisichella taking the car to the last win and titles for a V10 powered Formula one car, marking the end of an era. This car also claimed Michelin's first (and also second-to-last) title since its return in Formula One, winning the title again with Renault (the R26 2006-spec car) in the 2006 season, the last for the French tyre maker. The R25 was the first constructors championship winning car since 1991 not to have been designed by either Adrian Newey or Rory Byrne.
Over 19 races, it scored 191 points, 8 wins, 15 podiums and was fully out of the points only once in 18 starts (not counting the United States Grand Prix where both Renault drivers, in common with all their fellow Michelin tyre runners, withdrew prior to starting).