Log page index: User:ProteinBoxBot/PBB_Log_Index
Protein Status Quick Log - Date: 21:04, 9 November 2007 (UTC)[edit]
Proteins without matches (18)[edit]
Proteins with a High Potential Match (7)[edit]
Created (11)[edit]
Manual Inspection (Page not found) (14)[edit]
Protein Status Grid - Date: 21:04, 9 November 2007 (UTC)[edit]
Vebose Log - Date: 21:04, 9 November 2007 (UTC)[edit]
- INFO: Beginning work on ABCG1... {November 9, 2007 12:50:48 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 12:51:43 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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| update_protein_box = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = ATP-binding cassette, sub-family G (WHITE), member 1
| HGNCid = 73
| Symbol = ABCG1
| AltSymbols =; ABC8; MGC34313; WHITE1
| OMIM = 603076
| ECnumber =
| Homologene = 21022
| MGIid = 107704
| GeneAtlas_image1 = PBB_GE_ABCG1_204567_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_ABCG1_211113_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0015196 |text = L-tryptophan transmembrane transporter activity}} {{GNF_GO|id=GO:0015216 |text = purine nucleotide transmembrane transporter activity}} {{GNF_GO|id=GO:0015646 |text = transmembrane transporter activity}} {{GNF_GO|id=GO:0016887 |text = ATPase activity}} {{GNF_GO|id=GO:0042626 |text = ATPase activity, coupled to transmembrane movement of substances}} {{GNF_GO|id=GO:0046983 |text = protein dimerization activity}}
| Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006869 |text = lipid transport}} {{GNF_GO|id=GO:0008203 |text = cholesterol metabolic process}} {{GNF_GO|id=GO:0009720 |text = detection of hormone stimulus}} {{GNF_GO|id=GO:0010033 |text = response to organic substance}} {{GNF_GO|id=GO:0042632 |text = cholesterol homeostasis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 9619
| Hs_Ensembl = ENSG00000160179
| Hs_RefseqProtein = NP_004906
| Hs_RefseqmRNA = NM_004915
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 21
| Hs_GenLoc_start = 42509335
| Hs_GenLoc_end = 42590421
| Hs_Uniprot = P45844
| Mm_EntrezGene = 11307
| Mm_Ensembl = ENSMUSG00000024030
| Mm_RefseqmRNA = NM_009593
| Mm_RefseqProtein = NP_033723
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 17
| Mm_GenLoc_start = 30784710
| Mm_GenLoc_end = 30842784
| Mm_Uniprot = Q0VDW9
}}
}}
'''ATP-binding cassette, sub-family G (WHITE), member 1''', also known as '''ABCG1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. It is involved in macrophage cholesterol and phospholipids transport, and may regulate cellular lipid homeostasis in other cell types. Several alternative splice variants have been identified.<ref>{{cite web | title = Entrez Gene: ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9619| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Schmitz G, Langmann T, Heimerl S |title=Role of ABCG1 and other ABCG family members in lipid metabolism. |journal=J. Lipid Res. |volume=42 |issue= 10 |pages= 1513-20 |year= 2002 |pmid= 11590207 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on BUB1B... {November 9, 2007 10:17:40 AM PST}
- CREATE: Found no pages, creating new page. {November 9, 2007 10:18:19 AM PST}
- CREATED: Created new protein page: BUB1B {November 9, 2007 10:18:26 AM PST}
- INFO: Beginning work on CCL7... {November 9, 2007 10:24:55 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein CCL7 image.jpg {November 9, 2007 10:25:26 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 10:26:23 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_CCL7_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1bo0.
| PDB = {{PDB2|1bo0}}, {{PDB2|1ncv}}
| Name = Chemokine (C-C motif) ligand 7
| HGNCid = 10634
| Symbol = CCL7
| AltSymbols =; FIC; MARC; MCP-3; MCP3; MGC138463; MGC138465; NC28; SCYA6; SCYA7
| OMIM = 158106
| ECnumber =
| Homologene = 4568
| MGIid = 99512
| GeneAtlas_image1 = PBB_GE_CCL7_208075_s_at_tn.png
| Function = {{GNF_GO|id=GO:0008009 |text = chemokine activity}} {{GNF_GO|id=GO:0008201 |text = heparin binding}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005615 |text = extracellular space}}
| Process = {{GNF_GO|id=GO:0006874 |text = cellular calcium ion homeostasis}} {{GNF_GO|id=GO:0006935 |text = chemotaxis}} {{GNF_GO|id=GO:0006954 |text = inflammatory response}} {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}} {{GNF_GO|id=GO:0019735 |text = antimicrobial humoral response}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6354
| Hs_Ensembl = ENSG00000108688
| Hs_RefseqProtein = NP_006264
| Hs_RefseqmRNA = NM_006273
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 17
| Hs_GenLoc_start = 29621354
| Hs_GenLoc_end = 29623373
| Hs_Uniprot = P80098
| Mm_EntrezGene = 20306
| Mm_Ensembl = ENSMUSG00000035373
| Mm_RefseqmRNA = NM_013654
| Mm_RefseqProtein = NP_038682
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 81861909
| Mm_GenLoc_end = 81863714
| Mm_Uniprot = Q5SVU0
}}
}}
'''Chemokine (C-C motif) ligand 7''', also known as '''CCL7''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes monocyte chemotactic protein 3, a secreted chemokine which attracts macrophages during inflammation and metastasis. It is a member of the C-C subfamily of chemokines which are characterized by having two adjacent cysteine residues. The protein is an in vivo substrate of matrix metalloproteinase 2, an enzyme which degrades components of the extracellular matrix. This gene is part of a cluster of C-C chemokine family members on chromosome 17q.<ref>{{cite web | title = Entrez Gene: CCL7 chemokine (C-C motif) ligand 7| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6354| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Menten P, Wuyts A, Van Damme J |title=Monocyte chemotactic protein-3. |journal=Eur. Cytokine Netw. |volume=12 |issue= 4 |pages= 554-60 |year= 2002 |pmid= 11781181 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CD163... {November 9, 2007 12:49:41 PM PST}
- CREATE: Found no pages, creating new page. {November 9, 2007 12:50:38 PM PST}
- CREATED: Created new protein page: CD163 {November 9, 2007 12:50:48 PM PST}
- INFO: Beginning work on CFB... {November 9, 2007 10:16:30 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein CFB image.jpg {November 9, 2007 10:17:19 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 10:17:40 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_CFB_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1dle.
| PDB = {{PDB2|1dle}}, {{PDB2|1q0p}}, {{PDB2|1rrk}}, {{PDB2|1rs0}}, {{PDB2|1rtk}}, {{PDB2|2ok5}}
| Name = Complement factor B
| HGNCid = 1037
| Symbol = CFB
| AltSymbols =; BF; BFD; CFAB; GBG; H2-Bf; PBF2
| OMIM = 138470
| ECnumber =
| Homologene = 1292
| MGIid = 105975
| GeneAtlas_image1 = PBB_GE_CFB_202357_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_CFB_211920_at_tn.png
| Function = {{GNF_GO|id=GO:0001848 |text = complement binding}} {{GNF_GO|id=GO:0003812 |text = alternative-complement-pathway C3/C5 convertase activity}} {{GNF_GO|id=GO:0004252 |text = serine-type endopeptidase activity}} {{GNF_GO|id=GO:0008233 |text = peptidase activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}}
| Process = {{GNF_GO|id=GO:0006508 |text = proteolysis}} {{GNF_GO|id=GO:0006956 |text = complement activation}} {{GNF_GO|id=GO:0006957 |text = complement activation, alternative pathway}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 629
| Hs_Ensembl = ENSG00000166285
| Hs_RefseqProtein = NP_001701
| Hs_RefseqmRNA = NM_001710
| Hs_GenLoc_db =
| Hs_GenLoc_chr = c6_COX
| Hs_GenLoc_start = 32048579
| Hs_GenLoc_end = 32054666
| Hs_Uniprot = P00751
| Mm_EntrezGene = 14962
| Mm_Ensembl = ENSMUSG00000024371
| Mm_RefseqmRNA = NM_008198
| Mm_RefseqProtein = NP_032224
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 17
| Mm_GenLoc_start = 34464437
| Mm_GenLoc_end = 34470273
| Mm_Uniprot = Q3U925
}}
}}
'''Complement factor B''', also known as '''CFB''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. This cluster includes several genes involved in regulation of the immune reaction. The polyadenylation site of this gene is 421 bp from the 5' end of the gene for complement component 2.<ref>{{cite web | title = Entrez Gene: CFB complement factor B| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=629| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Campbell RD |title=The molecular genetics and polymorphism of C2 and factor B. |journal=Br. Med. Bull. |volume=43 |issue= 1 |pages= 37-49 |year= 1988 |pmid= 3315100 |doi= }}
*{{cite journal | author=Campbell RD, Bentley DR, Morley BJ |title=The factor B and C2 genes. |journal=Philos. Trans. R. Soc. Lond., B, Biol. Sci. |volume=306 |issue= 1129 |pages= 367-78 |year= 1984 |pmid= 6149579 |doi= }}
*{{cite journal | author=Yu CY |title=Molecular genetics of the human MHC complement gene cluster. |journal=Exp. Clin. Immunogenet. |volume=15 |issue= 4 |pages= 213-30 |year= 1999 |pmid= 10072631 |doi= }}
*{{cite journal | author=Rawal N, Pangburn MK |title=Structure/function of C5 convertases of complement. |journal=Int. Immunopharmacol. |volume=1 |issue= 3 |pages= 415-22 |year= 2001 |pmid= 11367526 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on DIO2... {November 9, 2007 10:19:16 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 10:19:36 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Deiodinase, iodothyronine, type II
| HGNCid = 2884
| Symbol = DIO2
| AltSymbols =; 5DII; D2; SelY; TXDI2
| OMIM = 601413
| ECnumber =
| Homologene = 621
| MGIid = 1338833
| Function = {{GNF_GO|id=GO:0004800 |text = thyroxine 5'-deiodinase activity}} {{GNF_GO|id=GO:0008430 |text = selenium binding}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0001514 |text = selenocysteine incorporation}} {{GNF_GO|id=GO:0006590 |text = thyroid hormone generation}} {{GNF_GO|id=GO:0042446 |text = hormone biosynthetic process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1734
| Hs_Ensembl =
| Hs_RefseqProtein = NP_000784
| Hs_RefseqmRNA = NM_000793
| Hs_GenLoc_db =
| Hs_GenLoc_chr =
| Hs_GenLoc_start =
| Hs_GenLoc_end =
| Hs_Uniprot =
| Mm_EntrezGene = 13371
| Mm_Ensembl = ENSMUSG00000007682
| Mm_RefseqmRNA = NM_010050
| Mm_RefseqProtein = NP_034180
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 12
| Mm_GenLoc_start = 91134815
| Mm_GenLoc_end = 91143674
| Mm_Uniprot = Q05A70
}}
}}
'''Deiodinase, iodothyronine, type II''', also known as '''DIO2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene belongs to the iodothyronine deiodinase family. It activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3,3',5-triiodothyronine (T3). It is highly expressed in the thyroid, and may contribute significantly to the relative increase in thyroidal T3 production in patients with Graves disease and thyroid adenomas. This protein contains selenocysteine (Sec) residues encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in multiple transcript variants encoding different isoforms.<ref>{{cite web | title = Entrez Gene: DIO2 deiodinase, iodothyronine, type II| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1734| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Gereben B, Salvatore D |title=Pretranslational regulation of type 2 deiodinase. |journal=Thyroid |volume=15 |issue= 8 |pages= 855-64 |year= 2006 |pmid= 16131328 |doi= 10.1089/thy.2005.15.855 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on DNM2... {November 9, 2007 10:19:36 AM PST}
- CREATE: Found no pages, creating new page. {November 9, 2007 10:19:57 AM PST}
- CREATED: Created new protein page: DNM2 {November 9, 2007 10:20:05 AM PST}
- INFO: Beginning work on GRB7... {November 9, 2007 10:20:57 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein GRB7 image.jpg {November 9, 2007 10:21:28 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 10:21:36 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_GRB7_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1mw4.
| PDB = {{PDB2|1mw4}}, {{PDB2|1wgr}}
| Name = Growth factor receptor-bound protein 7
| HGNCid = 4567
| Symbol = GRB7
| AltSymbols =;
| OMIM = 601522
| ECnumber =
| Homologene = 3881
| MGIid = 102683
| GeneAtlas_image1 = PBB_GE_GRB7_210761_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005070 |text = SH3/SH2 adaptor activity}}
| Component =
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007173 |text = epidermal growth factor receptor signaling pathway}} {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2886
| Hs_Ensembl = ENSG00000141738
| Hs_RefseqProtein = NP_001025173
| Hs_RefseqmRNA = NM_001030002
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 17
| Hs_GenLoc_start = 35147713
| Hs_GenLoc_end = 35157061
| Hs_Uniprot = Q14451
| Mm_EntrezGene = 14786
| Mm_Ensembl = ENSMUSG00000019312
| Mm_RefseqmRNA = NM_010346
| Mm_RefseqProtein = NP_034476
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 98262929
| Mm_GenLoc_end = 98271460
| Mm_Uniprot = Q3TH55
}}
}}
'''Growth factor receptor-bound protein 7''', also known as '''GRB7''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with epidermal growth factor receptor (EGFR) and ephrin receptors. The protein plays a role in the integrin signaling pathway and cell migration by binding with focal adhesion kinase (FAK). Alternative splicing results in multiple transcript variants encoding different isoforms, although the full-length natures of only two of the variants have been determined to date.<ref>{{cite web | title = Entrez Gene: GRB7 growth factor receptor-bound protein 7| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2886| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Han DC, Shen TL, Guan JL |title=The Grb7 family proteins: structure, interactions with other signaling molecules and potential cellular functions. |journal=Oncogene |volume=20 |issue= 44 |pages= 6315-21 |year= 2001 |pmid= 11607834 |doi= 10.1038/sj.onc.1204775 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on HDAC5... {November 9, 2007 12:52:43 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 12:53:25 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Histone deacetylase 5
| HGNCid = 14068
| Symbol = HDAC5
| AltSymbols =; FLJ90614; HD5; NY-CO-9
| OMIM = 605315
| ECnumber =
| Homologene = 3995
| MGIid = 1333784
| GeneAtlas_image1 = PBB_GE_HDAC5_202455_at_tn.png
| Function = {{GNF_GO|id=GO:0003714 |text = transcription corepressor activity}} {{GNF_GO|id=GO:0004407 |text = histone deacetylase activity}} {{GNF_GO|id=GO:0008134 |text = transcription factor binding}} {{GNF_GO|id=GO:0016566 |text = specific transcriptional repressor activity}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}}
| Component = {{GNF_GO|id=GO:0000118 |text = histone deacetylase complex}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0016604 |text = nuclear body}}
| Process = {{GNF_GO|id=GO:0000074 |text = regulation of progression through cell cycle}} {{GNF_GO|id=GO:0000122 |text = negative regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0006338 |text = chromatin remodeling}} {{GNF_GO|id=GO:0006342 |text = chromatin silencing}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006954 |text = inflammatory response}} {{GNF_GO|id=GO:0007507 |text = heart development}} {{GNF_GO|id=GO:0030183 |text = B cell differentiation}} {{GNF_GO|id=GO:0045843 |text = negative regulation of striated muscle development}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 10014
| Hs_Ensembl = ENSG00000108840
| Hs_RefseqProtein = NP_001015053
| Hs_RefseqmRNA = NM_001015053
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 17
| Hs_GenLoc_start = 39509647
| Hs_GenLoc_end = 39556540
| Hs_Uniprot = Q9UQL6
| Mm_EntrezGene = 15184
| Mm_Ensembl = ENSMUSG00000008855
| Mm_RefseqmRNA = NM_001077696
| Mm_RefseqProtein = NP_001071164
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 102011839
| Mm_GenLoc_end = 102046214
| Mm_Uniprot = Q3TSM2
}}
}}
'''Histone deacetylase 5''', also known as '''HDAC5''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene.<ref>{{cite web | title = Entrez Gene: HDAC5 histone deacetylase 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10014| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Nakajima D, Okazaki N, Yamakawa H, ''et al.'' |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. |journal=DNA Res. |volume=9 |issue= 3 |pages= 99-106 |year= 2003 |pmid= 12168954 |doi= }}
*{{cite journal | author=Verdin E, Dequiedt F, Kasler HG |title=Class II histone deacetylases: versatile regulators. |journal=Trends Genet. |volume=19 |issue= 5 |pages= 286-93 |year= 2003 |pmid= 12711221 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on HIST1H3B... {November 9, 2007 12:45:30 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein HIST1H3B image.jpg {November 9, 2007 12:45:50 PM PST}
- CREATE: Found no pages, creating new page. {November 9, 2007 12:46:07 PM PST}
- CREATED: Created new protein page: HIST1H3B {November 9, 2007 12:46:14 PM PST}
- INFO: Beginning work on HMGCR... {November 9, 2007 10:21:36 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein HMGCR image.jpg {November 9, 2007 10:22:25 AM PST}
- CREATE: Found no pages, creating new page. {November 9, 2007 10:22:33 AM PST}
- CREATED: Created new protein page: HMGCR {November 9, 2007 10:22:40 AM PST}
- INFO: Beginning work on IKZF1... {November 9, 2007 12:53:25 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 12:54:44 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = IKAROS family zinc finger 1 (Ikaros)
| HGNCid = 13176
| Symbol = IKZF1
| AltSymbols =; IK1; Hs.54452; IKAROS; LYF1; PRO0758; ZNFN1A1; hIk-1
| OMIM = 603023
| ECnumber =
| Homologene = 55948
| MGIid = 1342540
| GeneAtlas_image1 = PBB_GE_IKZF1_205039_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_IKZF1_216901_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007498 |text = mesoderm development}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 10320
| Hs_Ensembl = ENSG00000185811
| Hs_RefseqProtein = NP_006051
| Hs_RefseqmRNA = NM_006060
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 7
| Hs_GenLoc_start = 50314924
| Hs_GenLoc_end = 50438053
| Hs_Uniprot = Q13422
| Mm_EntrezGene = 22778
| Mm_Ensembl = ENSMUSG00000018654
| Mm_RefseqmRNA = NM_001025597
| Mm_RefseqProtein = NP_001020768
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 11585928
| Mm_GenLoc_end = 11672929
| Mm_Uniprot = Q5GGW4
}}
}}
'''IKAROS family zinc finger 1 (Ikaros)''', also known as '''IKZF1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Tonnelle C, Calmels B, Maroc C, ''et al.'' |title=Ikaros gene expression and leukemia. |journal=Leuk. Lymphoma |volume=43 |issue= 1 |pages= 29-35 |year= 2003 |pmid= 11908734 |doi= }}
*{{cite journal | author=Westman BJ, Mackay JP, Gell D |title=Ikaros: a key regulator of haematopoiesis. |journal=Int. J. Biochem. Cell Biol. |volume=34 |issue= 10 |pages= 1304-7 |year= 2002 |pmid= 12127581 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on IL1R2... {November 9, 2007 12:44:21 PM PST}
- CREATE: Found no pages, creating new page. {November 9, 2007 12:45:20 PM PST}
- CREATED: Created new protein page: IL1R2 {November 9, 2007 12:45:30 PM PST}
- INFO: Beginning work on MBD2... {November 9, 2007 12:46:56 PM PST}
- CREATE: Found no pages, creating new page. {November 9, 2007 12:48:13 PM PST}
- CREATED: Created new protein page: MBD2 {November 9, 2007 12:48:26 PM PST}
- INFO: Beginning work on MTA1... {November 9, 2007 12:48:27 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein MTA1 image.jpg {November 9, 2007 12:49:25 PM PST}
- CREATE: Found no pages, creating new page. {November 9, 2007 12:49:33 PM PST}
- CREATED: Created new protein page: MTA1 {November 9, 2007 12:49:41 PM PST}
- INFO: Beginning work on NKX2-5... {November 9, 2007 10:18:26 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 10:19:16 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = NK2 transcription factor related, locus 5 (Drosophila)
| HGNCid = 2488
| Symbol = NKX2-5
| AltSymbols =; CSX; CSX1; NKX2.5; NKX2E
| OMIM = 600584
| ECnumber =
| Homologene = 3230
| MGIid = 97350
| GeneAtlas_image1 = PBB_GE_NKX2-5_206578_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0016564 |text = transcription repressor activity}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}} {{GNF_GO|id=GO:0046982 |text = protein heterodimerization activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005667 |text = transcription factor complex}}
| Process = {{GNF_GO|id=GO:0000122 |text = negative regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0001947 |text = heart looping}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0007512 |text = adult heart development}} {{GNF_GO|id=GO:0035050 |text = embryonic heart tube development}} {{GNF_GO|id=GO:0045944 |text = positive regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0048738 |text = cardiac muscle development}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1482
| Hs_Ensembl = ENSG00000183072
| Hs_RefseqProtein = NP_004378
| Hs_RefseqmRNA = NM_004387
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 5
| Hs_GenLoc_start = 172591744
| Hs_GenLoc_end = 172594868
| Hs_Uniprot = P52952
| Mm_EntrezGene = 18091
| Mm_Ensembl = ENSMUSG00000015579
| Mm_RefseqmRNA = NM_008700
| Mm_RefseqProtein = NP_032726
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 17
| Mm_GenLoc_start = 26566254
| Mm_GenLoc_end = 26569154
| Mm_Uniprot = Q3UQU2
}}
}}
'''NK2 transcription factor related, locus 5 (Drosophila)''', also known as '''NKX2-5''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Homeobox-containing genes play critical roles in regulating tissue-specific gene expression essential for tissue differentiation, as well as determining the temporal and spatial patterns of development (Shiojima et al., 1995). It has been demonstrated that a Drosophila homeobox-containing gene called 'tinman' is expressed in the developing dorsal vessel and in the equivalent of the vertebrate heart. Mutations in tinman result in loss of heart formation in the embryo, suggesting that tinman is essential for Drosophila heart formation. Furthermore, abundant expression of Csx, the presumptive mouse homolog of tinman, is observed only in the heart from the time of cardiac differentiation. CSX, the human homolog of murine Csx, has a homeodomain sequence identical to that of Csx and is expressed only in the heart, again suggesting that CSX plays an important role in human heart formation.[supplied by OMIM]<ref>{{cite web | title = Entrez Gene: NKX2-5 NK2 transcription factor related, locus 5 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1482| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Harvey RP, Lai D, Elliott D, ''et al.'' |title=Homeodomain factor Nkx2-5 in heart development and disease. |journal=Cold Spring Harb. Symp. Quant. Biol. |volume=67 |issue= |pages= 107-14 |year= 2003 |pmid= 12858530 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on NR5A2... {November 9, 2007 10:20:05 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein NR5A2 image.jpg {November 9, 2007 10:20:20 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 10:20:57 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_NR5A2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1yok.
| PDB = {{PDB2|1yok}}, {{PDB2|1yuc}}, {{PDB2|1zdu}}, {{PDB2|2a66}}, {{PDB2|2ff0}}
| Name = Nuclear receptor subfamily 5, group A, member 2
| HGNCid = 7984
| Symbol = NR5A2
| AltSymbols =; B1F; B1F2; CPF; FTF; FTZ-F1; FTZ-F1beta; LRH-1; hB1F; hB1F-2
| OMIM = 604453
| ECnumber =
| Homologene = 20827
| MGIid = 1346834
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003705 |text = RNA polymerase II transcription factor activity, enhancer binding}} {{GNF_GO|id=GO:0003707 |text = steroid hormone receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0008289 |text = lipid binding}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006366 |text = transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0008206 |text = bile acid metabolic process}} {{GNF_GO|id=GO:0009653 |text = anatomical structure morphogenesis}} {{GNF_GO|id=GO:0009790 |text = embryonic development}} {{GNF_GO|id=GO:0042592 |text = homeostatic process}} {{GNF_GO|id=GO:0042632 |text = cholesterol homeostasis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2494
| Hs_Ensembl = ENSG00000116833
| Hs_RefseqProtein = NP_003813
| Hs_RefseqmRNA = NM_003822
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 198263353
| Hs_GenLoc_end = 198413175
| Hs_Uniprot = O00482
| Mm_EntrezGene = 26424
| Mm_Ensembl = ENSMUSG00000026398
| Mm_RefseqmRNA = XM_990082
| Mm_RefseqProtein = XP_995176
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 1
| Mm_GenLoc_start = 138660687
| Mm_GenLoc_end = 138776859
| Mm_Uniprot = Q1WLP7
}}
}}
'''Nuclear receptor subfamily 5, group A, member 2''', also known as '''NR5A2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on PSIP1... {November 9, 2007 12:54:44 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein PSIP1 image.jpg {November 9, 2007 12:56:01 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 12:56:28 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_PSIP1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1z9e.
| PDB = {{PDB2|1z9e}}, {{PDB2|2b4j}}
| Name = PC4 and SFRS1 interacting protein 1
| HGNCid = 9527
| Symbol = PSIP1
| AltSymbols =; p75; p52; DFS70; LEDGF; MGC74712; PAIP; PSIP2
| OMIM = 603620
| ECnumber =
| Homologene = 13242
| MGIid = 2142116
| GeneAtlas_image1 = PBB_GE_PSIP1_210758_at_tn.png
| GeneAtlas_image2 = PBB_GE_PSIP1_205961_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_PSIP1_209337_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 11168
| Hs_Ensembl = ENSG00000164985
| Hs_RefseqProtein = NP_066967
| Hs_RefseqmRNA = NM_021144
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 9
| Hs_GenLoc_start = 15454064
| Hs_GenLoc_end = 15501017
| Hs_Uniprot = O75475
| Mm_EntrezGene = 101739
| Mm_Ensembl = ENSMUSG00000028484
| Mm_RefseqmRNA = NM_133948
| Mm_RefseqProtein = NP_598709
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 4
| Mm_GenLoc_start = 82926911
| Mm_GenLoc_end = 82957621
| Mm_Uniprot = Q05CD2
}}
}}
'''PC4 and SFRS1 interacting protein 1''', also known as '''PSIP1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Van Maele B, Debyser Z |title=HIV-1 integration: an interplay between HIV-1 integrase, cellular and viral proteins. |journal=AIDS reviews |volume=7 |issue= 1 |pages= 26-43 |year= 2005 |pmid= 15875659 |doi= }}
*{{cite journal | author=Van Maele B, Busschots K, Vandekerckhove L, ''et al.'' |title=Cellular co-factors of HIV-1 integration. |journal=Trends Biochem. Sci. |volume=31 |issue= 2 |pages= 98-105 |year= 2006 |pmid= 16403635 |doi= 10.1016/j.tibs.2005.12.002 }}
*{{cite journal | author=Freed EO, Mouland AJ |title=The cell biology of HIV-1 and other retroviruses. |journal=Retrovirology |volume=3 |issue= |pages= 77 |year= 2006 |pmid= 17083721 |doi= 10.1186/1742-4690-3-77 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on RBX1... {November 9, 2007 12:51:44 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein RBX1 image.jpg {November 9, 2007 12:52:13 PM PST}
- CREATE: Found no pages, creating new page. {November 9, 2007 12:52:34 PM PST}
- CREATED: Created new protein page: RBX1 {November 9, 2007 12:52:43 PM PST}
- INFO: Beginning work on REST... {November 9, 2007 10:22:40 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 10:23:37 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = RE1-silencing transcription factor
| HGNCid = 9966
| Symbol = REST
| AltSymbols =; NRSF; XBR
| OMIM = 600571
| ECnumber =
| Homologene = 4099
| MGIid = 104897
| GeneAtlas_image1 = PBB_GE_REST_212920_at_tn.png
| GeneAtlas_image2 = PBB_GE_REST_204535_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003676 |text = nucleic acid binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016564 |text = transcription repressor activity}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5978
| Hs_Ensembl = ENSG00000084093
| Hs_RefseqProtein = NP_005603
| Hs_RefseqmRNA = NM_005612
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 4
| Hs_GenLoc_start = 57468832
| Hs_GenLoc_end = 57496767
| Hs_Uniprot = Q13127
| Mm_EntrezGene = 19712
| Mm_Ensembl = ENSMUSG00000029249
| Mm_RefseqmRNA = NM_011263
| Mm_RefseqProtein = NP_035393
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 5
| Mm_GenLoc_start = 78342716
| Mm_GenLoc_end = 78357759
| Mm_Uniprot = A0JNY8
}}
}}
'''RE1-silencing transcription factor''', also known as '''REST''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a transcriptional repressor which represses neuronal genes in non-neuronal tissues. It is a member of the Kruppel-type zinc finger transcription factor family. It represses transcription by binding a DNA sequence element called the neuron-restrictive silencer element. The protein is also found in undifferentiated neuronal progenitor cells, and it is thought that this repressor may act as a master negative regular of neurogenesis. Alternatively spliced transcript variants have been described; however, their full length nature has not been determined.<ref>{{cite web | title = Entrez Gene: REST RE1-silencing transcription factor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5978| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on RPL5... {November 9, 2007 10:23:37 AM PST}
- CREATE: Found no pages, creating new page. {November 9, 2007 10:24:47 AM PST}
- CREATED: Created new protein page: RPL5 {November 9, 2007 10:24:55 AM PST}
- INFO: Beginning work on TMSB4X... {November 9, 2007 10:26:23 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 12:42:19 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Thymosin, beta 4, X-linked
| HGNCid = 11881
| Symbol = TMSB4X
| AltSymbols =; FX; PTMB4; TB4X; TMSB4
| OMIM = 300159
| ECnumber =
| Homologene =
| MGIid =
| GeneAtlas_image1 = PBB_GE_TMSB4X_216438_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003779 |text = actin binding}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005856 |text = cytoskeleton}}
| Process = {{GNF_GO|id=GO:0007010 |text = cytoskeleton organization and biogenesis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 7114
| Hs_Ensembl = ENSG00000205542
| Hs_RefseqProtein = NP_066932
| Hs_RefseqmRNA = NM_021109
| Hs_GenLoc_db =
| Hs_GenLoc_chr = X
| Hs_GenLoc_start = 12903148
| Hs_GenLoc_end = 12905267
| Hs_Uniprot = P62328
| Mm_EntrezGene =
| Mm_Ensembl =
| Mm_RefseqmRNA =
| Mm_RefseqProtein =
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Thymosin, beta 4, X-linked''', also known as '''TMSB4X''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes an actin sequestering protein which plays a role in regulation of actin polymerization. The protein is also involved in cell proliferation, migration, and differentiation. This gene escapes X inactivation and has a homolog on chromosome Y.<ref>{{cite web | title = Entrez Gene: TMSB4X thymosin, beta 4, X-linked| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7114| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Huff T, Müller CS, Otto AM, ''et al.'' |title=beta-Thymosins, small acidic peptides with multiple functions. |journal=Int. J. Biochem. Cell Biol. |volume=33 |issue= 3 |pages= 205-20 |year= 2001 |pmid= 11311852 |doi= }}
*{{cite journal | author=Bubb MR |title=Thymosin beta 4 interactions. |journal=Vitam. Horm. |volume=66 |issue= |pages= 297-316 |year= 2003 |pmid= 12852258 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on TNFSF14... {November 9, 2007 12:46:14 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 12:46:56 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Tumor necrosis factor (ligand) superfamily, member 14
| HGNCid = 11930
| Symbol = TNFSF14
| AltSymbols =; TR2; CD258; HVEML; LIGHT; LTg
| OMIM = 604520
| ECnumber =
| Homologene = 2822
| MGIid = 1355317
| GeneAtlas_image1 = PBB_GE_TNFSF14_207907_at_tn.png
| Function = {{GNF_GO|id=GO:0005125 |text = cytokine activity}} {{GNF_GO|id=GO:0005164 |text = tumor necrosis factor receptor binding}} {{GNF_GO|id=GO:0043027 |text = caspase inhibitor activity}}
| Component = {{GNF_GO|id=GO:0005615 |text = extracellular space}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006917 |text = induction of apoptosis}} {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0008588 |text = release of cytoplasmic sequestered NF-kappaB}} {{GNF_GO|id=GO:0043029 |text = T cell homeostasis}} {{GNF_GO|id=GO:0050798 |text = activated T cell proliferation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 8740
| Hs_Ensembl = ENSG00000125735
| Hs_RefseqProtein = NP_003798
| Hs_RefseqmRNA = NM_003807
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 19
| Hs_GenLoc_start = 6615568
| Hs_GenLoc_end = 6621599
| Hs_Uniprot = O43557
| Mm_EntrezGene = 50930
| Mm_Ensembl = ENSMUSG00000005824
| Mm_RefseqmRNA = NM_019418
| Mm_RefseqProtein = NP_062291
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 17
| Mm_GenLoc_start = 56874827
| Mm_GenLoc_end = 56879512
| Mm_Uniprot = Q059Y9
}}
}}
'''Tumor necrosis factor (ligand) superfamily, member 14''', also known as '''TNFSF14''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF14, which is a member of the tumor necrosis factor receptor superfamily, and which is also known as a herpesvirus entry mediator (HVEM). This protein may function as a costimulatory factor for the activation of lymphoid cells and as a deterrent to infection by herpesvirus. This protein has been shown to stimulate the proliferation of T cells, and trigger apoptosis of various tumor cells. This protein is also reported to prevent tumor necrosis factor alpha mediated apoptosis in primary hepatocyte. Two alternatively spliced transcript variant encoding distinct isoforms have been reported.<ref>{{cite web | title = Entrez Gene: TNFSF14 tumor necrosis factor (ligand) superfamily, member 14| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8740| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Yang D, Zhai Y, Zhang M |title=LIGHT, a new member of the TNF superfamily. |journal=J. Biol. Regul. Homeost. Agents |volume=16 |issue= 3 |pages= 206-10 |year= 2003 |pmid= 12456019 |doi= }}
*{{cite journal | author=Bénichou S, Benmerah A |title=[The HIV nef and the Kaposi-sarcoma-associated virus K3/K5 proteins: "parasites"of the endocytosis pathway] |journal=Med Sci (Paris) |volume=19 |issue= 1 |pages= 100-6 |year= 2003 |pmid= 12836198 |doi= }}
*{{cite journal | author=Anderson JL, Hope TJ |title=HIV accessory proteins and surviving the host cell. |journal=Current HIV/AIDS reports |volume=1 |issue= 1 |pages= 47-53 |year= 2005 |pmid= 16091223 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on U2AF1... {November 9, 2007 12:42:19 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein U2AF1 image.jpg {November 9, 2007 12:42:55 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 12:43:17 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_U2AF1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1jmt.
| PDB = {{PDB2|1jmt}}
| Name = U2 small nuclear RNA auxiliary factor 1
| HGNCid = 12453
| Symbol = U2AF1
| AltSymbols =; DKFZp313J1712; FP793; RN; RNU2AF1; U2AF35; U2AFBP
| OMIM = 191317
| ECnumber =
| Homologene = 14345
| MGIid = 98884
| GeneAtlas_image1 = PBB_GE_U2AF1_202858_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003723 |text = RNA binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005681 |text = spliceosome}} {{GNF_GO|id=GO:0015030 |text = Cajal body}}
| Process = {{GNF_GO|id=GO:0000398 |text = nuclear mRNA splicing, via spliceosome}} {{GNF_GO|id=GO:0008380 |text = RNA splicing}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 7307
| Hs_Ensembl = ENSG00000160201
| Hs_RefseqProtein = NP_001020374
| Hs_RefseqmRNA = NM_001025203
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 21
| Hs_GenLoc_start = 43386136
| Hs_GenLoc_end = 43400757
| Hs_Uniprot = Q01081
| Mm_EntrezGene = 108121
| Mm_Ensembl = ENSMUSG00000061613
| Mm_RefseqmRNA = NM_024187
| Mm_RefseqProtein = NP_077149
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 17
| Mm_GenLoc_start = 31375793
| Mm_GenLoc_end = 31387432
| Mm_Uniprot = Q14C24
}}
}}
'''U2 small nuclear RNA auxiliary factor 1''', also known as '''U2AF1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene belongs to the splicing factor SR family of genes. U2 auxiliary factor, comprising a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. This gene encodes the small subunit which plays a critical role in both constitutive and enhancer-dependent RNA splicing by directly mediating interactions between the large subunit and proteins bound to the enhancers. Alternatively spliced transcript variants encoding different isoforms have been identified.<ref>{{cite web | title = Entrez Gene: U2AF1 U2 small nuclear RNA auxiliary factor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7307| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on XRCC3... {November 9, 2007 12:43:17 PM PST}
- CREATE: Found no pages, creating new page. {November 9, 2007 12:44:12 PM PST}
- CREATED: Created new protein page: XRCC3 {November 9, 2007 12:44:21 PM PST}
end log.
