Liver receptor homolog-1

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Nuclear receptor subfamily 5, group A, member 2
Protein NR5A2 PDB 1yok.png
PDB rendering based on 1yok.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols NR5A2 ; B1F; B1F2; CPF; FTF; FTZ-F1; FTZ-F1beta; LRH-1; LRH1; hB1F-2
External IDs OMIM604453 MGI1346834 HomoloGene20827 IUPHAR: NR5A2 ChEMBL: 3544 GeneCards: NR5A2 Gene
Orthologs
Species Human Mouse
Entrez 2494 26424
Ensembl ENSG00000116833 ENSMUSG00000026398
UniProt O00482 P45448
RefSeq (mRNA) NM_001276464 NM_001159769
RefSeq (protein) NP_001263393 NP_001153241
Location (UCSC) Chr 1:
200 – 200.15 Mb
Chr 1:
136.84 – 136.96 Mb
PubMed search [1] [2]

The liver receptor homolog-1 (LRH-1) also known as NR5A2 (nuclear receptor subfamily 5, group A, member 2) is a protein that in humans is encoded by the NR5A2 gene.[1][2] LRH-1 is a member of the nuclear receptor family of intracellular transcription factors.

LRH-1 plays a critical role in the regulation of development, cholesterol transport, bile acid homeostasis and steroidogenesis.[3][4][5]

LRH-1 is important for maintaining pluripotence of stem cells during embryonic development.[6]


Interactions[edit]

Liver receptor homolog-1 has been shown to interact with the small heterodimer partner.[7][8]

References[edit]

  1. ^ Bernier D, Thomassin H, Allard D, et al. (1993). "Functional analysis of developmentally regulated chromatin-hypersensitive domains carrying the alpha 1-fetoprotein gene promoter and the albumin/alpha 1-fetoprotein intergenic enhancer". Mol. Cell. Biol. 13 (3): 1619–33. PMC 359474. PMID 7680097. 
  2. ^ Galarneau L, Drouin R, Bélanger L (1998). "Assignment of the fetoprotein transcription factor gene (FTF) to human chromosome band 1q32.11 by in situ hybridization". Cytogenet. Cell Genet. 82 (3–4): 269–70. doi:10.1159/000015116. PMID 9858833. 
  3. ^ Fayard E, Auwerx J, Schoonjans K (2004). "LRH-1: an orphan nuclear receptor involved in development, metabolism and steroidogenesis". Trends Cell Biol. 14 (5): 250–60. doi:10.1016/j.tcb.2004.03.008. PMID 15130581. 
  4. ^ Luo, Y.; Liang, C. P.; Tall, A. R. (2001). "The Orphan Nuclear Receptor LRH-1 Potentiates the Sterol-mediated Induction of the Human CETP Gene by Liver X Receptor". Journal of Biological Chemistry 276 (27): 24767–24773. doi:10.1074/jbc.M100912200. PMID 11331284.  edit
  5. ^ Nitta, M.; Ku, S.; Brown, C.; Okamoto, A. Y.; Shan, B. (1999). "CPF: An orphan nuclear receptor that regulates liver-specific expression of the human cholesterol 7alpha -hydroxylase gene". Proceedings of the National Academy of Sciences 96 (12): 6660–6665. doi:10.1073/pnas.96.12.6660. PMC 21971. PMID 10359768.  edit
  6. ^ Gu, P.; Goodwin, B.; Chung, A. C. -K.; Xu, X.; Wheeler, D. A.; Price, R. R.; Galardi, C.; Peng, L.; Latour, A. M.; Koller, B. H.; Gossen, J.; Kliewer, S. A.; Cooney, A. J. (2005). "Orphan Nuclear Receptor LRH-1 is Required to Maintain Oct4 Expression at the Epiblast Stage of Embryonic Development". Molecular and Cellular Biology 25 (9): 3492–3505. doi:10.1128/MCB.25.9.3492-3505.2005. PMC 1084298. PMID 15831456.  edit
  7. ^ Brendel C, Schoonjans K, Botrugno OA, Treuter E, Auwerx J (September 2002). "The small heterodimer partner interacts with the liver X receptor alpha and represses its transcriptional activity". Mol. Endocrinol. 16 (9): 2065–76. doi:10.1210/me.2001-0194. PMID 12198243. 
  8. ^ Lee YK, Moore DD (January 2002). "Dual mechanisms for repression of the monomeric orphan receptor liver receptor homologous protein-1 by the orphan small heterodimer partner". J. Biol. Chem. 277 (4): 2463–7. doi:10.1074/jbc.M105161200. PMID 11668176. 

Further reading[edit]

External links[edit]