MTA1

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This article is about proteins. For the Islamic TV channel, see MTA 1.
Metastasis associated 1
Protein MTA1 PDB 2crg.png
PDB rendering based on 2crg.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbol MTA1
External IDs OMIM603526 MGI2150037 HomoloGene3442 GeneCards: MTA1 Gene
RNA expression pattern
PBB GE MTA1 202247 s at tn.png
PBB GE MTA1 211783 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 9112 116870
Ensembl ENSG00000182979 ENSMUSG00000021144
UniProt Q13330 Q8K4B0
RefSeq (mRNA) NM_001203258 NM_054081
RefSeq (protein) NP_001190187 NP_473422
Location (UCSC) Chr 14:
105.89 – 105.94 Mb
Chr 12:
113.1 – 113.14 Mb
PubMed search [1] [2]

Metastasis-associated protein MTA1 is a protein that in humans is encoded by the MTA1 gene.[1][2]

Function[edit]

This gene encodes a protein that was identified in a screen for genes expressed in metastatic cells, specifically, mammary adenocarcinoma cell lines. Expression of this gene has been correlated with the metastatic potential of at least two types of carcinomas although it is also expressed in many normal tissues. The role it plays in metastasis is unclear. It was initially thought to be the 70kD component of a nucleosome remodeling deacetylase complex, NuRD, but it is more likely that this component is a different but very similar protein. These two proteins are so closely related, though, that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. The profile and activity of this gene product suggest that it is involved in regulating transcription and that this may be accomplished by chromatin remodeling.[3]

Interactions[edit]

MTA1 has been shown to interact with:

MTA1 has also been shown to inhibit SMAD7 at the transcriptional level.[9]

References[edit]

  1. ^ Toh Y, Pencil SD, Nicolson GL (Sep 1994). "A novel candidate metastasis-associated gene, mta1, differentially expressed in highly metastatic mammary adenocarcinoma cell lines. cDNA cloning, expression, and protein analyses". The Journal of Biological Chemistry 269 (37): 22958–63. PMID 8083195. 
  2. ^ Toh Y, Pencil SD, Nicolson GL (Jun 1995). "Analysis of the complete sequence of the novel metastasis-associated candidate gene, mta1, differentially expressed in mammary adenocarcinoma and breast cancer cell lines". Gene 159 (1): 97–104. doi:10.1016/0378-1119(94)00410-T. PMID 7607577. 
  3. ^ "Entrez Gene: MTA1 metastasis associated 1". 
  4. ^ a b c Mazumdar A, Wang RA, Mishra SK, Adam L, Bagheri-Yarmand R, Mandal M et al. (Jan 2001). "Transcriptional repression of oestrogen receptor by metastasis-associated protein 1 corepressor". Nature Cell Biology 3 (1): 30–7. doi:10.1038/35050532. PMID 11146623. 
  5. ^ Kumar R, Wang RA, Mazumdar A, Talukder AH, Mandal M, Yang Z et al. (Aug 2002). "A naturally occurring MTA1 variant sequesters oestrogen receptor-alpha in the cytoplasm". Nature 418 (6898): 654–7. doi:10.1038/nature00889. PMID 12167865. 
  6. ^ a b c Yao YL, Yang WM (Oct 2003). "The metastasis-associated proteins 1 and 2 form distinct protein complexes with histone deacetylase activity". The Journal of Biological Chemistry 278 (43): 42560–8. doi:10.1074/jbc.M302955200. PMID 12920132. 
  7. ^ Hakimi MA, Dong Y, Lane WS, Speicher DW, Shiekhattar R (Feb 2003). "A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes". The Journal of Biological Chemistry 278 (9): 7234–9. doi:10.1074/jbc.M208992200. PMID 12493763. 
  8. ^ Talukder AH, Mishra SK, Mandal M, Balasenthil S, Mehta S, Sahin AA et al. (Mar 2003). "MTA1 interacts with MAT1, a cyclin-dependent kinase-activating kinase complex ring finger factor, and regulates estrogen receptor transactivation functions". The Journal of Biological Chemistry 278 (13): 11676–85. doi:10.1074/jbc.M209570200. PMID 12527756. 
  9. ^ Salot S, Gude R (Jan 2013). "MTA1-mediated transcriptional repression of SMAD7 in breast cancer cell lines". European Journal of Cancer 49 (2). doi:10.1016/j.ejca.2012.06.019. PMID 22841502. 

Further reading[edit]

  • Nicolson GL, Nawa A, Toh Y, Taniguchi S, Nishimori K, Moustafa A (2003). "Tumor metastasis-associated human MTA1 gene and its MTA1 protein product: role in epithelial cancer cell invasion, proliferation and nuclear regulation". Clinical & Experimental Metastasis 20 (1): 19–24. doi:10.1023/A:1022534217769. PMID 12650603. 
  • Xue Y, Wong J, Moreno GT, Young MK, Côté J, Wang W (Dec 1998). "NURD, a novel complex with both ATP-dependent chromatin-remodeling and histone deacetylase activities". Molecular Cell 2 (6): 851–61. doi:10.1016/S1097-2765(00)80299-3. PMID 9885572.  Vancouver style error (help)
  • Zhang Y, Ng HH, Erdjument-Bromage H, Tempst P, Bird A, Reinberg D (Aug 1999). "Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation". Genes & Development 13 (15): 1924–35. doi:10.1101/gad.13.15.1924. PMC 316920. PMID 10444591. 
  • Toh Y, Kuninaka S, Endo K, Oshiro T, Ikeda Y, Nakashima H et al. (Mar 2000). "Molecular analysis of a candidate metastasis-associated gene, MTA1: possible interaction with histone deacetylase 1". Journal of Experimental & Clinical Cancer Research 19 (1): 105–11. PMID 10840944. 
  • Nawa A, Nishimori K, Lin P, Maki Y, Moue K, Sawada H et al. (Aug 2000). "Tumor metastasis-associated human MTA1 gene: its deduced protein sequence, localization, and association with breast cancer cell proliferation using antisense phosphorothioate oligonucleotides". Journal of Cellular Biochemistry 79 (2): 202–12. doi:10.1002/1097-4644(20001101)79:2<202::AID-JCB40>3.0.CO;2-L. PMID 10967548. 
  • Mazumdar A, Wang RA, Mishra SK, Adam L, Bagheri-Yarmand R, Mandal M et al. (Jan 2001). "Transcriptional repression of oestrogen receptor by metastasis-associated protein 1 corepressor". Nature Cell Biology 3 (1): 30–7. doi:10.1038/35050532. PMID 11146623. 
  • Cui Q, Takiguchi S, Matsusue K, Toh Y, Yoshida MA (2001). "Assignment of the human metastasis-associated gene 1 (MTA1) to human chromosome band 14q32.3 by fluorescence in situ hybridization". Cytogenetics and Cell Genetics 93 (1-2): 139–40. doi:10.1159/000056969. PMID 11474200. 
  • Simpson A, Uitto J, Rodeck U, Mahoney MG (Jul 2001). "Differential expression and subcellular distribution of the mouse metastasis-associated proteins Mta1 and Mta3". Gene 273 (1): 29–39. doi:10.1016/S0378-1119(01)00563-7. PMID 11483358. 
  • Sasaki H, Moriyama S, Nakashima Y, Kobayashi Y, Yukiue H, Kaji M et al. (Feb 2002). "Expression of the MTA1 mRNA in advanced lung cancer". Lung Cancer 35 (2): 149–54. doi:10.1016/S0169-5002(01)00329-4. PMID 11804687. 
  • Mahoney MG, Simpson A, Jost M, Noé M, Kari C, Pepe D et al. (Mar 2002). "Metastasis-associated protein (MTA)1 enhances migration, invasion, and anchorage-independent survival of immortalized human keratinocytes". Oncogene 21 (14): 2161–70. doi:10.1038/sj.onc.1205277. PMID 11948399.  Vancouver style error (help)
  • Kumar R, Wang RA, Mazumdar A, Talukder AH, Mandal M, Yang Z et al. (Aug 2002). "A naturally occurring MTA1 variant sequesters oestrogen receptor-alpha in the cytoplasm". Nature 418 (6898): 654–7. doi:10.1038/nature00889. PMID 12167865. 
  • Yan C, Wang H, Toh Y, Boyd DD (Jan 2003). "Repression of 92-kDa type IV collagenase expression by MTA1 is mediated through direct interactions with the promoter via a mechanism, which is both dependent on and independent of histone deacetylation". The Journal of Biological Chemistry 278 (4): 2309–16. doi:10.1074/jbc.M210369200. PMID 12431981. 
  • Hakimi MA, Dong Y, Lane WS, Speicher DW, Shiekhattar R (Feb 2003). "A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes". The Journal of Biological Chemistry 278 (9): 7234–9. doi:10.1074/jbc.M208992200. PMID 12493763. 
  • Talukder AH, Mishra SK, Mandal M, Balasenthil S, Mehta S, Sahin AA et al. (Mar 2003). "MTA1 interacts with MAT1, a cyclin-dependent kinase-activating kinase complex ring finger factor, and regulates estrogen receptor transactivation functions". The Journal of Biological Chemistry 278 (13): 11676–85. doi:10.1074/jbc.M209570200. PMID 12527756. 
  • Mishra SK, Mazumdar A, Vadlamudi RK, Li F, Wang RA, Yu W et al. (May 2003). "MICoA, a novel metastasis-associated protein 1 (MTA1) interacting protein coactivator, regulates estrogen receptor-alpha transactivation functions". The Journal of Biological Chemistry 278 (21): 19209–19. doi:10.1074/jbc.M301968200. PMID 12639951. 
  • Hamatsu T, Rikimaru T, Yamashita Y, Aishima S, Tanaka S, Shirabe K et al. (2003). "The role of MTA1 gene expression in human hepatocellular carcinoma". Oncology Reports 10 (3): 599–604. PMID 12684630. 

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.