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==Phylogenetics==
==Phylogenetics==
Sequences of Wuhan betacoronavirus show similarities to [[betacoronavirus]]es found in [[bat]]s; however, the virus is genetically distinct from other [[coronavirus]]es such as ''[[Severe acute respiratory syndrome-related coronavirus]]'' (SARS) and ''[[Middle East respiratory syndrome-related coronavirus]]'' (MERS).<ref name=":1" /> Like SARS-CoV, it is a member of Beta-CoV lineage B<ref>{{cite web |title=Phylogeny of SARS-like betacoronaviruses |url=https://nextstrain.org/groups/blab/sars-like-cov |website=nextstrain |accessdate=18 January 2020}}</ref><ref>Hui DS, I Azhar E, Madani TA, Ntoumi F, Kock R, Dar O, Ippolito G, Mchugh TD, Memish ZA, Drosten C, Zumla A, Petersen E. The continuing 2019-nCoV epidemic threat of novel coronaviruses to global health - The latest 2019 novel coronavirus outbreak in Wuhan, China. ''Int J Infect Dis''. 2020 Jan 14;91:264-266. {{pmid|31953166}} {{doi|10.1016/j.ijid.2020.01.009}} {{open access}}</ref> (i. e. subgenus ''[[Sarbecovirus]]''<ref name="Wong2019">Antonio C. P. Wong, Xin Li, Susanna K. P. Lau, Patrick C. Y. Woo: [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409556/ Global Epidemiology of Bat Coronaviruses], in: Viruses. 2019 Feb; 11(2): 174, [[doi:10.3390/v11020174]]</ref>).
Sequences of Wuhan betacoronavirus show similarities to [[betacoronavirus]]es found in [[bat]]s; however, the virus is genetically distinct from other [[coronavirus]]es such as ''[[Severe acute respiratory syndrome-related coronavirus]]'' (SARS) and ''[[Middle East respiratory syndrome-related coronavirus]]'' (MERS).<ref name=":1" /> Like SARS-CoV, it is a member of Beta-CoV lineage B<ref>{{cite web |title=Phylogeny of SARS-like betacoronaviruses |url=https://nextstrain.org/groups/blab/sars-like-cov |website=nextstrain |accessdate=18 January 2020}}</ref><ref>Hui DS, I Azhar E, Madani TA, Ntoumi F, Kock R, Dar O, Ippolito G, Mchugh TD, Memish ZA, Drosten C, Zumla A, Petersen E. The continuing 2019-nCoV epidemic threat of novel coronaviruses to global health - The latest 2019 novel coronavirus outbreak in Wuhan, China. ''Int J Infect Dis''. 2020 Jan 14;91:264-266. {{pmid|31953166}} {{doi|10.1016/j.ijid.2020.01.009}} {{open access}}</ref> (i. e. subgenus ''[[Sarbecovirus]]''<ref name="Wong2019">Antonio C. P. Wong, Xin Li, Susanna K. P. Lau, Patrick C. Y. Woo: [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409556/ Global Epidemiology of Bat Coronaviruses], in: Viruses. 2019 Feb; 11(2): 174, [[doi:10.3390/v11020174]]</ref>).
Five genomes of the novel coronavirus have been isolated and reported including BetaCoV/Wuhan/IVDC-HB-01/2019, BetaCoV/Wuhan/IVDC-HB-04/2020, BetaCoV/Wuhan/IVDC-HB-05/2019, BetaCoV/Wuhan/WIV04/2019, and BetaCoV/Wuhan/IPBCAMS-WH-01/2019 from the [[Chinese Center for Disease Control and Prevention|China CDC]], [[Institute of Pathogen Biology]], and [[Wuhan Jinyintan Hospital]].<ref name=":1" /><ref>{{cite web|url=http://virological.org/t/initial-genome-release-of-novel-coronavirus/319|title=Initial genome release of novel coronavirus|date=11 January 2020|website=Virological|language=en-US|access-date=12 January 2020}}</ref><ref>{{Cite journal|date=2020-01-17|title=Wuhan seafood market pneumonia virus isolate Wuhan-Hu-1, complete genome|url=http://www.ncbi.nlm.nih.gov/nuccore/MN908947.3|language=en-US|publisher=www.ncbi.nlm.nih.gov}}</ref> Its [[RNA]] sequence is approximately 30 [[Base pair#Length measurements|kb]] in length.<ref name=":1" />
Eighteen<ref>{{Cite web|url=https://nextstrain.org/ncov|title=Genomic epidemiology of novel coronavirus (nCoV) using data generated by Fudan University, China CDC, Chinese Academy of Medical Sciences, Chinese Academy of Sciences, Zhejiang Provincial Center for Disease Control and Prevention and the Thai National Institute of Health shared via GISAID|last=|first=|date=|website=nextstrain.org|url-status=live|archive-url=|archive-date=|access-date=2020-01-22}}</ref> genomes of the novel coronavirus have been isolated and reported including BetaCoV/Wuhan/IVDC-HB-01/2019, BetaCoV/Wuhan/IVDC-HB-04/2020, BetaCoV/Wuhan/IVDC-HB-05/2019, BetaCoV/Wuhan/WIV04/2019, and BetaCoV/Wuhan/IPBCAMS-WH-01/2019 from the [[Chinese Center for Disease Control and Prevention|China CDC]], [[Institute of Pathogen Biology]], and [[Wuhan Jinyintan Hospital]].<ref name=":1" /><ref>{{cite web|url=http://virological.org/t/initial-genome-release-of-novel-coronavirus/319|title=Initial genome release of novel coronavirus|date=11 January 2020|website=Virological|language=en-US|access-date=12 January 2020}}</ref><ref>{{Cite journal|date=2020-01-17|title=Wuhan seafood market pneumonia virus isolate Wuhan-Hu-1, complete genome|url=http://www.ncbi.nlm.nih.gov/nuccore/MN908947.3|language=en-US|publisher=www.ncbi.nlm.nih.gov}}</ref> Its [[RNA]] sequence is approximately 30 [[Base pair#Length measurements|kb]] in length.<ref name=":1" />


==See also==
==See also==

Revision as of 19:47, 22 January 2020

Novel coronavirus (2019-nCoV)
Virus classification Edit this classification
(unranked): Virus
Realm: Riboviria
Kingdom: Orthornavirae
Phylum: Pisuviricota
Class: Pisoniviricetes
Order: Nidovirales
Family: Coronaviridae
Genus: Betacoronavirus
Subgenus: Sarbecovirus
Virus:
Novel coronavirus (2019-nCoV)
SARS-CoV-2 is located in China
SARS-CoV-2
Wuhan, China, the primary location of the only recorded outbreak
Synonyms
  • Wuhan seafood market pneumonia virus
  • Wuhan pneumonia
  • Wuhan coronavirus
Genomic information
NCBI genome IDMN908947
Genome size30473 bases
Year of completion2020

Novel coronavirus, denoted 2019-nCoV by the WHO[1][2] and also known as Wuhan coronavirus, Wuhan flu, Wuhan seafood market pneumonia virus and Wuhan pneumonia,[3] is a positive-sense, single-stranded RNA coronavirus first reported in 2019. The virus was genomically sequenced after nucleic acid testing on a positive patient sample in a patient with pneumonia during the 2019–2020 Wuhan pneumonia outbreak.[4][5][6]

On 20 January 2020, human-to-human transmission was confirmed in Guangdong province, China, according to Zhong Nanshan, head of the health commission team investigating the outbreak.[7] No specific treatment for the new virus is currently available, but existing anti-virals could be repurposed.[8]

The virus has spread to Bangkok, Tokyo, South Korea, Beijing, Shanghai, Guangdong Province, Taiwan, and the U.S. state of Washington.[9] There have been 17 fatalities, mostly in and around Wuhan and 541 known cases.[10][11][12][13]

Phylogenetics

Sequences of Wuhan betacoronavirus show similarities to betacoronaviruses found in bats; however, the virus is genetically distinct from other coronaviruses such as Severe acute respiratory syndrome-related coronavirus (SARS) and Middle East respiratory syndrome-related coronavirus (MERS).[6] Like SARS-CoV, it is a member of Beta-CoV lineage B[14][15] (i. e. subgenus Sarbecovirus[16]). Eighteen[17] genomes of the novel coronavirus have been isolated and reported including BetaCoV/Wuhan/IVDC-HB-01/2019, BetaCoV/Wuhan/IVDC-HB-04/2020, BetaCoV/Wuhan/IVDC-HB-05/2019, BetaCoV/Wuhan/WIV04/2019, and BetaCoV/Wuhan/IPBCAMS-WH-01/2019 from the China CDC, Institute of Pathogen Biology, and Wuhan Jinyintan Hospital.[6][18][19] Its RNA sequence is approximately 30 kb in length.[6]

See also

Diseases caused by genetically similar viruses:

References

  1. ^ "Surveillance case definitions for human infection with novel coronavirus (nCoV)". www.who.int. Retrieved 21 January 2020.
  2. ^ "Novel coronavirus (2019-nCoV), Wuhan, China". www.cdc.gov. cdc.gov. 10 January 2020. Retrieved 16 January 2020.{{cite web}}: CS1 maint: url-status (link)
  3. ^ Zhang, Y.-Z.; et al. (12 January 2020). "Wuhan seafood market pneumonia virus isolate Wuhan-Hu-1, complete genome". GenBank. Bethesda MD. Retrieved 13 January 2020.
  4. ^ "中国疾病预防控制中心". www.chinacdc.cn. Retrieved 9 January 2020.
  5. ^ "New-type coronavirus causes pneumonia in Wuhan: expert – Xinhua | English.news.cn". www.xinhuanet.com. Retrieved 9 January 2020.
  6. ^ a b c d "CoV2020". platform.gisaid.org. Retrieved 12 January 2020.{{cite web}}: CS1 maint: url-status (link)
  7. ^ "China confirms human-to-human transmission of new coronavirus". CBC News. 20 January 2020. Retrieved 21 January 2020.{{cite news}}: CS1 maint: url-status (link)
  8. ^ "WHO says new China coronavirus could spread, warns hospitals worldwide". Reuters. 14 January 2020. Retrieved 21 January 2020.
  9. ^ "China Virus Spreads to U.S. With Health Officials on High Alert". Bloomberg.com. 21 January 2020. Retrieved 21 January 2020.
  10. ^ "Wuhan virus: China reports fourth death in pneumonia outbreak; 15 medical workers infected". straitstimes. Retrieved 20 January 2020.
  11. ^ "CNBC: CDC confirms first US case of coronavirus that has killed 9 in China". Berkeley Lovelace Jr. Retrieved 22 January 2020.
  12. ^ "China virus death toll rises to nine". 9news.au. Retrieved 22 January 2020.
  13. ^ "Death toll from virus outbreak in China's Hubei reaches 17: State TV". Channelnewsasia. Retrieved 22 January 2020.
  14. ^ "Phylogeny of SARS-like betacoronaviruses". nextstrain. Retrieved 18 January 2020.
  15. ^ Hui DS, I Azhar E, Madani TA, Ntoumi F, Kock R, Dar O, Ippolito G, Mchugh TD, Memish ZA, Drosten C, Zumla A, Petersen E. The continuing 2019-nCoV epidemic threat of novel coronaviruses to global health - The latest 2019 novel coronavirus outbreak in Wuhan, China. Int J Infect Dis. 2020 Jan 14;91:264-266. PMID 31953166 doi:10.1016/j.ijid.2020.01.009 Open access icon
  16. ^ Antonio C. P. Wong, Xin Li, Susanna K. P. Lau, Patrick C. Y. Woo: Global Epidemiology of Bat Coronaviruses, in: Viruses. 2019 Feb; 11(2): 174, doi:10.3390/v11020174
  17. ^ "Genomic epidemiology of novel coronavirus (nCoV) using data generated by Fudan University, China CDC, Chinese Academy of Medical Sciences, Chinese Academy of Sciences, Zhejiang Provincial Center for Disease Control and Prevention and the Thai National Institute of Health shared via GISAID". nextstrain.org. Retrieved 22 January 2020.{{cite web}}: CS1 maint: url-status (link)
  18. ^ "Initial genome release of novel coronavirus". Virological. 11 January 2020. Retrieved 12 January 2020.
  19. ^ "Wuhan seafood market pneumonia virus isolate Wuhan-Hu-1, complete genome". www.ncbi.nlm.nih.gov. 17 January 2020. {{cite journal}}: Cite journal requires |journal= (help)
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