Calico cat: Difference between revisions
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==Genetics== |
==Genetics== |
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The beginning of serious study of calico cats seems to have occurred |
The beginning of serious study of calico cats seems to have occurred around 1948 when [[Murray L. Barr|Murray Barr]] and his graduate student E.G. Bertram noticed dark, drumstick-shaped masses inside the nuclei of nerve cells of female cats, but not in male cats. These dark masses became known as [[Barr body|Barr bodies]].<ref name=travis2000>John Travis. "Silence of the Xs". ''Science News''. '''158''' (6): 92–94. 5 August 2000.</ref> In 1959, Japanese cell biologist Susumu Ohno determined the Barr bodies were [[X chromosome]]s.<ref name=travis2000/> In 1960, [[Mary F. Lyon|Mary Lyon]] proposed the concept of [[X inactivation|X-inactivation]]: one of the two X chromosomes inside a female [[mammal]] shuts off.<ref name=travis2000/> She observed this in the coat color patterns in mice.<ref>Gilbert, Scott F. "Transcriptional Regulation of an Entire Chromosome: Dosage Compensation." Developmental Biology. Sunderland, Mass.: Sinauer Associates, 2000. Print.</ref> |
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Calico cats are almost always female because the [[X chromosome]] determines the color of the cat and female cats, much like all female mammals, have two X chromosomes, whereas male mammals, including common male cats, have one X and one Y chromosome.<ref name=Mosaicism/><ref name=travis2000/><ref name=Gunter2005>Gunter, Chris. "She Moves in Mysterious Ways". ''Nature'' 17 March 2005.</ref> Since the Y chromosome does not have any color genes, there is no chance he could have both orange and non-orange together. One main exception to this is when, in rare cases, a male has XXY chromosomes (see [[Klinefelter's syndrome]]), in which case the male could have tortoiseshell or calico markings. Most male calico or tortoiseshell cats are [[Sterility (physiology)|sterile]] due to the abnormality of carrying two X chromosomes. Few of these males can breed (1 in 3,000) and are rejected by breeders for studding purposes. "In the case of a calico cat, the feline’s parents passed on different versions of X chromosomes genes related to coat color."<ref name=travis2000/> |
Calico cats are almost always female because the [[X chromosome]] determines the color of the cat and female cats, much like all female mammals, have two X chromosomes, whereas male mammals, including common male cats, have one X and one Y chromosome.<ref name=Mosaicism/><ref name=travis2000/><ref name=Gunter2005>Gunter, Chris. "She Moves in Mysterious Ways". ''Nature'' 17 March 2005.</ref> Since the Y chromosome does not have any color genes, there is no chance he could have both orange and non-orange together. One main exception to this is when, in rare cases, a male has XXY chromosomes (see [[Klinefelter's syndrome]]), in which case the male could have tortoiseshell or calico markings. Most male calico or tortoiseshell cats are [[Sterility (physiology)|sterile]] due to the abnormality of carrying two X chromosomes. Few of these males can breed (1 in 3,000) and are rejected by breeders for studding purposes. "In the case of a calico cat, the feline’s parents passed on different versions of X chromosomes genes related to coat color."<ref name=travis2000/> |
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Revision as of 23:25, 10 July 2012
Calico cats are domestic cats with a spotted or parti-colored coat that is predominantly white, with patches of two other colors (often the two other colors are orange tabby and black). Outside of North America the pattern is more usually called tortoiseshell-and-white. In the province of Quebec, they are unofficially considered a breed by the French-speaking population and called chatte d'Espagne (French for 'Spain's female cat'). Other names include tricolor cat, mi-ke (Japanese for 'triple fur') and lapjeskat (Dutch for 'patches cat'); calicoes with diluted coloration have been called calimanco or clouded tiger.
"Calico" refers only to a color pattern on the fur, not to a breed.[1] It is absent from lists of breeds.[2] Among the breeds whose standards allow calico coloration are the Manx, American Shorthair, British Shorthair, Persian, Japanese Bobtail, Exotic Shorthair and Turkish Van.
Because genetic determination of some coat colors in cats is linked to the X chromosome, calicoes are nearly always female.[1][3]
History
Historical migration
As calico cats are not a breed, but a color pattern on the fur which occurs in a non-predictive manner, there is no true historical background concerning calico cats. However, the existence of patches in calico cats was traced to a certain degree by Neil Todd in a study determining the migration of domesticated cats along trade routes in Europe and Northern Africa. The proportion of cats having the orange mutant gene found in calicoes was traced to the port cities along the Mediterranean in France and Italy, originating from Egypt.[4]
Genetics
The beginning of serious study of calico cats seems to have occurred around 1948 when Murray Barr and his graduate student E.G. Bertram noticed dark, drumstick-shaped masses inside the nuclei of nerve cells of female cats, but not in male cats. These dark masses became known as Barr bodies.[5] In 1959, Japanese cell biologist Susumu Ohno determined the Barr bodies were X chromosomes.[5] In 1960, Mary Lyon proposed the concept of X-inactivation: one of the two X chromosomes inside a female mammal shuts off.[5] She observed this in the coat color patterns in mice.[6]
Calico cats are almost always female because the X chromosome determines the color of the cat and female cats, much like all female mammals, have two X chromosomes, whereas male mammals, including common male cats, have one X and one Y chromosome.[1][5][7] Since the Y chromosome does not have any color genes, there is no chance he could have both orange and non-orange together. One main exception to this is when, in rare cases, a male has XXY chromosomes (see Klinefelter's syndrome), in which case the male could have tortoiseshell or calico markings. Most male calico or tortoiseshell cats are sterile due to the abnormality of carrying two X chromosomes. Few of these males can breed (1 in 3,000) and are rejected by breeders for studding purposes. "In the case of a calico cat, the feline’s parents passed on different versions of X chromosomes genes related to coat color."[5] The color of calico or tortoiseshell cats is determined by the X chromosome(s). Tortoiseshell and calico cats are almost always female because of X chromosome inactivation.[8][9]
As Sue Hubble stated in her book Shrinking the Cat: Genetic Engineering before We Knew about Genes, "The mutation that gives male cats a ginger-colored coat and females ginger, tortoiseshell, or calico coats produced a particularly telling map. The orange mutant gene is found only on the X, or female, chromosome. As with humans, female cats have paired sex chromosomes, XX, and male cats have XY sex chromosomes. The female cat, therefore, can have the orange mutant gene on one X chromosome and the genes for a black or white coat on the other, and those can affect or modify the orange mutant gene. If that is the case, those several genes will be expressed in a blotchy coat of the tortoiseshell or calico kind. But the male, with his single X chromosome, has only one of that particular coat-color gene: he can be not-ginger or he can be ginger (although some modifier genes can add a bit of white here and there), but unless he has a chromosomal abnormality he cannot be a calico cat."[4]
It is currently impossible to reproduce the fur patterns of calico cats by cloning. "This is due to an effect called x-linked inactivation which involves the random inactivation of one of the X chromosomes. Since all female mammals have two X chromosomes, one might wonder if this phenomenon could have a more widespread impact on cloning in the future."[10]
Calico cats may have already provided findings relating to physiological differences between male and female mammals. This insight may be one day broadened to the fields of psychology, psychiatry, sociology, biology and medicine as more information becomes available regarding the complete effect of random X-inactivation in female mammal.[5][7][11]
Folklore
Cats of this coloration are believed to bring good luck in the folklore of many cultures.[12] In the United States, these are sometimes referred to as money cats.[13] The Japanese Maneki Neko figurine is almost always a calico cat.
See also
- Bicolor cat
- Point (coat color)
- Tabby cat
- Maltese cat
- Deaf white cat
- Cat coat genetics
- Tortoiseshell cat
- The Cat Who Went to Heaven
References
- ^ a b c Robinson, Richard. "Mosaicism". Genetics. New York: Macmillan Reference USA, 2003. 76-80.
- ^ Marilyn Menotti-Raymond, Victor A. David, Solveig M. Pflueger, Kerstin Lindblad-Toh, Claire M. Wade, Stephen J. O’Briena, Warren E. Johnson. “Patterns of molecular genetic variation among cat breeds.” Science Direct. 17 August 2007. Web. <[1][dead link]>.
- ^ "Encyclopædia Britannica. Encyclopædia Britannica Online". Encyclopædia Britannica. Retrieved 6 June 2010.
{{cite web}}:|chapter=ignored (help) - ^ a b Hubbell, Sue. Shrinking the Cat: Genetic Engineering before We Knew about Genes. Boston: Houghton Mifflin, 2001.
- ^ a b c d e f John Travis. "Silence of the Xs". Science News. 158 (6): 92–94. 5 August 2000.
- ^ Gilbert, Scott F. "Transcriptional Regulation of an Entire Chromosome: Dosage Compensation." Developmental Biology. Sunderland, Mass.: Sinauer Associates, 2000. Print.
- ^ a b Gunter, Chris. "She Moves in Mysterious Ways". Nature 17 March 2005.
- ^ Lyon, M.F. (2001). "Tortoiseshell coloring". In Brenner, Sydney (ed.). Encyclopedia of Genetics. Amsterdam: Elsevier. pp. 1970–1971. doi:10.1006/rwgn.2001.1296.
- ^ "X Inactivation". Howard Hughes Medical Institute, 5 October 2009. Accessed 22 May 2010.
- ^ Tsernoglou, Penelope Ann. "To Clone or Not to Clone: A Look at Why Cloning Fluffy and Fido Might Not Be in the Best Interests of Society and May Inevitably Pave the Way for Human Cloning." 25 April 2004. Web. 24 April 2010. <http://www.law.msu.edu>.
- ^ Pearson-White, Sonia. "Mammalian Genetics: X/imprinting". The University of Virginia. 2004. Accessed 23 May 2010.
- ^ Hartwell, Sarah (1995). "Feline Folktails - Cats in Folklore and Superstition". Retrieved 22 January 2009.
- ^ Finegan, Edward; Rickford, John (2004). "Language in the USA: Themes for the Twenty-first Century". Cambridge University Press. Retrieved 22 January 2009.
