Pseudomonas: Difference between revisions
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===Sensitivity to gallium=== |
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Although gallium has no natural function in biology, gallium ions interact with cellular processes in a manner similar to iron(III). When gallium ions are mistakenly taken up in place of iron(III) by bacteria such as Pseudomonas, the ions interfere with respiration, and the bacteria die. This happens because iron is redox-active, allowing the transfer of electrons during respiration, while gallium is redox-inactive. |
Although gallium has no natural function in biology, gallium ions interact with cellular processes in a manner similar to iron(III). When gallium ions are mistakenly taken up in place of iron(III) by bacteria such as Pseudomonas, the ions interfere with respiration, and the bacteria die. This happens because iron is redox-active, allowing the transfer of electrons during respiration, while gallium is redox-inactive.<ref></ref> |
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==Taxonomy== |
==Taxonomy== |
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Revision as of 09:43, 13 October 2016
Pseudomonas is a genus of Gram-negative, aerobic Gammaproteobacteria, belonging to the family Pseudomonadaceae and containing 191 validly described species.[1] The members of the genus demonstrate a great deal of metabolic diversity and consequently are able to colonize a wide range of niches.[2] Their ease of culture in vitro and availability of an increasing number of Pseudomonas strain genome sequences has made the genus an excellent focus for scientific research; the best studied species include P. aeruginosa in its role as an opportunistic human pathogen, the plant pathogen P. syringae, the soil bacterium P. putida, and the plant growth-promoting P. fluorescens.
Because of their widespread occurrence in water and plant seeds such as dicots, the pseudomonads were observed early in the history of microbiology. The generic name Pseudomonas created for these organisms was defined in rather vague terms by Walter Migula in 1894 and 1900 as a genus of Gram-negative, rod-shaped and polar-flagellated bacteria with some sporulating species,[3][4] the latter statement was later proved incorrect and was due to refractive granules of reserve materials.[5] Despite the vague description, the type species, Pseudomonas pyocyanea (basonym of Pseudomonas aeruginosa), proved the best descriptor.[5]
Classification history
Like most bacterial genera, the pseudomonad[note 1] last common ancestor lived hundreds of millions of years ago. They were initially classified at the end of the 19th century when first identified by Walter Migula. The etymology of the name was not specified at the time and first appeared in the seventh edition of Bergey's Manual of Systematic Bacteriology (the main authority in bacterial nomenclature) as Greek pseudes (ψευδής) "false" and -monas (μονάς/μονάδος) "a single unit", which can mean false unit; however, Migula possibly intended it as false Monas, a nanoflagellated protist[5] (subsequently, the term "monad" was used in the early history of microbiology to denote unicellular organisms). Soon, other species matching Migula's somewhat vague original description were isolated from many natural niches and, at the time, many were assigned to the genus. However, many strains have since been reclassified, based on more recent methodology and use of approaches involving studies of conservative macromolecules.[6]
Recently, 16S rRNA sequence analysis has redefined the taxonomy of many bacterial species.[7] As a result, the genus Pseudomonas includes strains formerly classified in the genera Chryseomonas and Flavimonas.[8] Other strains previously classified in the genus Pseudomonas are now classified in the genera Burkholderia and Ralstonia.[9][10]
In 2000, the complete genome sequence of a Pseudomonas species was determined; more recently, the sequence of other strains has been determined, including P. aeruginosa strains PAO1 (2000), P. putida KT2440 (2002), P. protegens Pf-5 (2005), P. syringae pathovar tomato DC3000 (2003), P. syringae pathovar syringae B728a (2005), P. syringae pathovar phaseolica 1448A (2005), P. fluorescens Pf0-1, and P. entomophila L48.[6]
Characteristics
Members of the genus display these defining characteristics:[11]
- Rod-shaped
- Gram-negative
- One or more polar flagella, providing motility
- Aerobic
- Non-spore forming
- Catalase-positive
- Oxidase-positive
Other characteristics that tend to be associated with Pseudomonas species (with some exceptions) include secretion of pyoverdine, a fluorescent yellow-green siderophore[12] under iron-limiting conditions. Certain Pseudomonas species may also produce additional types of siderophore, such as pyocyanin by Pseudomonas aeruginosa[13] and thioquinolobactin by Pseudomonas fluorescens,.[14] Pseudomonas species also typically give a positive result to the oxidase test, the absence of gas formation from glucose, glucose is oxidised in oxidation/fermentation test using Hugh and Leifson O/F test, beta hemolytic (on blood agar), indole negative, methyl red negative, Voges–Proskauer test negative, and citrate positive.
Pseudomonas may be the most common nucleator of ice crystals in clouds, thereby being of utmost importance to the formation of snow and rain around the world.[15]
Biofilm formation
All species and strains of Pseudomonas have historically been classified as strict aerobes. Exceptions to this classification have recently been discovered in Pseudomonas biofilms.[16] A significant number of cells can produce exopolysaccharides associated with biofilm formation. Secretion of exopolysaccharides such as alginate makes it difficult for pseudomonads to be phagocytosed by mammalian white blood cells.[17] Exopolysaccharide production also contributes to surface-colonising biofilms that are difficult to remove from food preparation surfaces. Growth of pseudomonads on spoiling foods can generate a "fruity" odor.
Antibiotic resistance
Being Gram-negative bacteria, most Pseudomonas spp. are naturally resistant to penicillin and the majority of related beta-lactam antibiotics, but a number are sensitive to piperacillin, imipenem, ticarcillin, or ciprofloxacin.[17] Aminoglycosides such as tobramycin, gentamicin, and amikacin are other choices for therapy.
This ability to thrive in harsh conditions is a result of their hardy cell walls that contain porins. Their resistance to most antibiotics is attributed to efflux pumps, which pump out some antibiotics before they are able to act.
Pseudomonas aeruginosa is increasingly recognized as an emerging opportunistic pathogen of clinical relevance. One of its most worrying characteristics is its low antibiotic susceptibility.[18] This low susceptibility is attributable to a concerted action of multidrug efflux pumps with chromosomally encoded antibiotic resistance genes (e.g., mexAB-oprM, mexXY, etc.,[19]) and the low permeability of the bacterial cellular envelopes. Besides intrinsic resistance, P. aeruginosa easily develops acquired resistance either by mutation in chromosomally encoded genes or by the horizontal gene transfer of antibiotic resistance determinants. Development of multidrug resistance by P. aeruginosa isolates requires several different genetic events that include acquisition of different mutations and/or horizontal transfer of antibiotic resistance genes. Hypermutation favours the selection of mutation-driven antibiotic resistance in P. aeruginosa strains producing chronic infections, whereas the clustering of several different antibiotic resistance genes in integrons favours the concerted acquisition of antibiotic resistance determinants. Some recent studies have shown phenotypic resistance associated to biofilm formation or to the emergence of small-colony-variants may be important in the response of P. aeruginosa populations to antibiotic treatment.[6]
Sensitivity to gallium
Although gallium has no natural function in biology, gallium ions interact with cellular processes in a manner similar to iron(III). When gallium ions are mistakenly taken up in place of iron(III) by bacteria such as Pseudomonas, the ions interfere with respiration, and the bacteria die. This happens because iron is redox-active, allowing the transfer of electrons during respiration, while gallium is redox-inactive.Cite error: There are <ref> tags on this page without content in them (see the help page).
Taxonomy
The studies on the taxonomy of this complicated genus groped their way in the dark while following the classical procedures developed for the description and identification of the organisms involved in sanitary bacteriology during the first decades of the 20th century. This situation sharply changed with the proposal to introduce as the central criterion the similarities in the composition and sequences of macromolecular components of the ribosomal RNA. The new methodology clearly showed the genus Pseudomonas, as classically defined, consists of a conglomerate of genera that could clearly be separated into five so-called rRNA homology groups. Moreover, the taxonomic studies suggested an approach that might prove useful in taxonomic studies of all other prokaryotic groups. A few decades after the proposal of the new genus Pseudomonas by Migula in 1894, the accumulation of species names assigned to the genus reached alarming proportions. The number of species in the current list has contracted more than 90%. In fact, this approximated reduction may be even more dramatic if one considers the present list contains many new names; i.e., relatively few names of the original list survived in the process. The new methodology and the inclusion of approaches based on the studies of conservative macromolecules other than rRNA components constitutes an effective prescription that helped to reduce Pseudomonas nomenclatural hypertrophy to a manageable size.[6]
Pathogenicity
Animal pathogens
Infectious species include P. aeruginosa, P. oryzihabitans, and P. plecoglossicida. P. aeruginosa flourishes in hospital environments, and is a particular problem in this environment, since it is the second-most common infection in hospitalized patients (nosocomial infections)[citation needed]. This pathogenesis may in part be due to the proteins secreted by P. aeruginosa. The bacterium possesses a wide range of secretion systems, which export numerous proteins relevant to the pathogenesis of clinical strains.[20]
Plant pathogens
P. syringae is a prolific plant pathogen. It exists as over 50 different pathovars, many of which demonstrate a high degree of host-plant specificity. Numerous other Pseudomonas species can act as plant pathogens, notably all of the other members of the P. syringae subgroup, but P. syringae is the most widespread and best-studied.
Although not strictly a plant pathogen, P. tolaasii can be a major agricultural problem, as it can cause bacterial blotch of cultivated mushrooms.[21] Similarly, P. agarici can cause drippy gill in cultivated mushrooms.[22]
Use as biocontrol agents
Since the mid-1980s, certain members of the Pseudomonas genus have been applied to cereal seeds or applied directly to soils as a way of preventing the growth or establishment of crop pathogens. This practice is generically referred to as biocontrol. The biocontrol properties of P. fluorescens and P. protegens strains (CHA0 or Pf-5 for example) are currently best-understood, although it is not clear exactly how the plant growth-promoting properties of P. fluorescens are achieved. Theories include: the bacteria might induce systemic resistance in the host plant, so it can better resist attack by a true pathogen; the bacteria might outcompete other (pathogenic) soil microbes, e.g. by siderophores giving a competitive advantage at scavenging for iron; the bacteria might produce compounds antagonistic to other soil microbes, such as phenazine-type antibiotics or hydrogen cyanide. Experimental evidence supports all of these theories.[23]
Other notable Pseudomonas species with biocontrol properties include P. chlororaphis, which produces a phenazine-type antibiotic active agent against certain fungal plant pathogens,[24] and the closely related species P. aurantiaca, which produces di-2,4-diacetylfluoroglucylmethane, a compound antibiotically active against Gram-positive organisms.[25]
Use as bioremediation agents
Some members of the genus are able to metabolise chemical pollutants in the environment, and as a result, can be used for bioremediation. Notable species demonstrated as suitable for use as bioremediation agents include:
- P. alcaligenes, which can degrade polycyclic aromatic hydrocarbons.[26]
- P. mendocina, which is able to degrade toluene.[27]
- P. pseudoalcaligenes, which is able to use cyanide as a nitrogen source.[28]
- P. resinovorans, which can degrade carbazole.[29]
- P. veronii, which has been shown to degrade a variety of simple aromatic organic compounds.[30][31]
- P. putida, which has the ability to degrade organic solvents such as toluene.[32] At least one strain of this bacterium is able to convert morphine in aqueous solution into the stronger and somewhat expensive to manufacture drug hydromorphone (Dilaudid).
- Strain KC of P. stutzeri, which is able to degrade carbon tetrachloride.[33]
Food spoilage agents
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As a result of their metabolic diversity, ability to grow at low temperatures, and ubiquitous nature, many Pseudomonas species can cause food spoilage. Notable examples include dairy spoilage by P. fragi,[34] mustiness in eggs caused by P. taetrolens and P. mudicolens,[35] and P. lundensis, which causes spoilage of milk, cheese, meat, and fish.[36]
Species previously classified in the genus
Recently, 16S rRNA sequence analysis redefined the taxonomy of many bacterial species previously classified as being in the Pseudomonas genus.[7] Species that moved from the Pseudomonas genus are listed below; clicking on a species will show its new classification. The term 'pseudomonad' does not apply strictly to just the Pseudomonas genus, and can be used to also include previous members such as the genera Burkholderia and Ralstonia.
α proteobacteria: P. abikonensis, P. aminovorans, P. azotocolligans, P. carboxydohydrogena, P. carboxidovorans, P. compransoris, P. diminuta, P. echinoides, P. extorquens, P. lindneri, P. mesophilica, P. paucimobilis, P. radiora, P. rhodos, P. riboflavina, P. rosea, P. vesicularis.
β proteobacteria: P. acidovorans, P. alliicola, P. antimicrobica, P. avenae, P. butanovorae, P. caryophylli, P. cattleyae, P. cepacia, P. cocovenenans, P. delafieldii, P. facilis, P. flava, P. gladioli, P. glathei, P. glumae, P. graminis, P. huttiensis, P. indigofera, P. lanceolata, P. lemoignei, P. mallei, P. mephitica, P. mixta, P. palleronii, P. phenazinium, P. pickettii, P. plantarii, P. pseudoflava, P. pseudomallei, P. pyrrocinia, P. rubrilineans, P. rubrisubalbicans, P. saccharophila, P. solanacearum, P. spinosa, P. syzygii, P. taeniospiralis, P. terrigena, P. testosteroni.
γ-β proteobacteria: P. beteli, P. boreopolis, P. cissicola, P. geniculata, P. hibiscicola, P. maltophilia, P. pictorum.
γ proteobacteria: P. beijerinckii, P. diminuta, P. doudoroffii, P. elongata, P. flectens, P. halodurans, P. halophila, P. iners, P. marina, P. nautica, P. nigrifaciens, P. pavonacea,[37] P. piscicida, P. stanieri.
δ proteobacteria: P. formicans.
Bacteriophage
There are a number of bacteriophage that infect Pseudomonas, e.g.
- Pseudomonas phage Φ6
- Pseudomonas aeruginosa phage EL [38]
- Pseudomonas aeruginosa phage ΦKMV [39]
- Pseudomonas aeruginosa phage LKD16 [40]
- Pseudomonas aeruginosa phage LKA1 [40]
- Pseudomonas aeruginosa phage LUZ19
- Pseudomonas aeruginosa phage ΦKZ [38]
See also
- culture collection for a list of culture collections
Footnotes
- ^ To aid in the flow of the prose in English, genus names can be "trivialised" to form a vernacular name to refer to a member of the genus: for the genus Pseudomonas it is "pseudomonad" (plural: "pseudomonads"), a variant on the non-nominative cases in the Greek declension of monas, monada.[41] For historical reasons, members of several genera that were formerly classified as Pseudomonas species can be referred to as pseudomonads, while the term "fluorescent pseudomonad" refers strictly to current members of the genus Pseudomonas, as these produce pyoverdin, a fluorescent siderophore.[2] The latter term, fluorescent pseudomonad, is distinct from the term P. fluorescens group, which is used to distinguish a subset of members of the Pseudomonas sensu stricto and not as a whole
References
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- ^ a b Madigan M; Martinko J, eds. (2005). Brock Biology of Microorganisms (11th ed.). Prentice Hall. ISBN 0-13-144329-1.
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- ^ Migula, W. (1900) System der Bakterien, Vol. 2. Jena, Germany: Gustav Fischer.
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- ^ a b c d Cornelis P, ed. (2008). Pseudomonas: Genomics and Molecular Biology (1st ed.). Caister Academic Press. ISBN 1-904455-19-0.
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- ^ Yabuuchi, E.; Kosako, Y.; Oyaizu, H.; Yano, I.; Hotta, H.; Hashimoto, Y.; Ezaki, T.; Arakawa, M. (1992). "Proposal of Burkholderia gen. Nov. And transfer of seven species of the genus Pseudomonas homology group II to the new genus, with the type species Burkholderia cepacia (Palleroni and Holmes 1981) comb. Nov". Microbiology and immunology. 36 (12): 1251–1275. doi:10.1111/j.1348-0421.1992.tb02129.x. PMID 1283774.
- ^ Yabuuchi, E.; Kosako, Y.; Yano, I.; Hotta, H.; Nishiuchi, Y. (1995). "Transfer of two Burkholderia and an Alcaligenes species to Ralstonia gen. Nov.: Proposal of Ralstonia pickettii (Ralston, Palleroni and Doudoroff 1973) comb. Nov., Ralstonia solanacearum (Smith 1896) comb. Nov. And Ralstonia eutropha (Davis 1969) comb. Nov". Microbiology and immunology. 39 (11): 897–904. doi:10.1111/j.1348-0421.1995.tb03275.x. PMID 8657018.
- ^ Krieg, Noel (1984). Bergey's Manual of Systematic Bacteriology, Volume 1. Baltimore: Williams & Wilkins. ISBN 0-683-04108-8.
- ^ Meyer JM; Geoffroy VA; Baida N; Gardan, L.; et al. (2002). "Siderophore typing, a powerful tool for the identification of fluorescent and nonfluorescent pseudomonads". Appl. Environ. Microbiol. 68 (6): 2745–2753. doi:10.1128/AEM.68.6.2745-2753.2002. PMC 123936. PMID 12039729.
- ^ Lau GW; Hassett DJ; Ran H; Kong F (2004). "The role of pyocyanin in Pseudomonas aeruginosa infection". Trends in molecular medicine. 10 (12): 599–606. doi:10.1016/j.molmed.2004.10.002. PMID 15567330.
- ^ Matthijs S; Tehrani KA; Laus G; Jackson RW; et al. (2007). "Thioquinolobactin, a Pseudomonas siderophore with antifungal and anti-Pythium activity". Environ. Microbiol. 9 (2): 425–434. doi:10.1111/j.1462-2920.2006.01154.x. PMID 17222140.
- ^ Biello, David (February 28, 2008) Do Microbes Make Snow? Scientific American
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- ^ Hardie (2009). "The Secreted Proteins of Pseudomonas aeruginosa: Their Export Machineries, and How They Contribute to Pathogenesis". Bacterial Secreted Proteins: Secretory Mechanisms and Role in Pathogenesis. Caister Academic Press. ISBN 978-1-904455-42-4.
- ^ Brodey CL; Rainey PB; Tester M; Johnstone K (1991). "Bacterial blotch disease of the cultivated mushroom is caused by an ion channel forming lipodepsipeptide toxin". Molecular Plant–Microbe Interaction. 1 (4): 407–11. doi:10.1094/MPMI-4-407.
- ^ Young JM (1970). "Drippy gill: a bacterial disease of cultivated mushrooms caused by Pseudomonas agarici n. sp". NZ J Agric Res. 13 (4): 977–90. doi:10.1080/00288233.1970.10430530.
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- ^ Chin-A-Woeng TF; Bloemberg, Guido V.; Mulders, Ine H. M.; Dekkers, Linda C.; et al. (2000). "Root colonization by phenazine-1-carboxamide-producing bacterium Pseudomonas chlororaphis PCL1391 is essential for biocontrol of tomato foot and root rot". Mol Plant Microbe Interact. 13 (12): 1340–1345. doi:10.1094/MPMI.2000.13.12.1340. PMID 11106026.
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- ^ Yen KM; Karl MR; Blatt LM; Simon, MJ; et al. (1991). "Cloning and characterization of a Pseudomonas mendocina KR1 gene cluster encoding toluene-4-monooxygenase". J. Bacteriol. 173 (17): 5315–27. PMC 208241. PMID 1885512.
- ^ Huertas MJ; Luque-Almagro VM; Martínez-Luque M; Blasco, R.; et al. (2006). "Cyanide metabolism of Pseudomonas pseudoalcaligenes CECT5344: role of siderophores". Biochem. Soc. Trans. 34 (Pt 1): 152–5. doi:10.1042/BST0340152. PMID 16417508.
- ^ Nojiri H; Maeda K; Sekiguchi H; Urata, Masaaki; et al. (2002). "Organization and transcriptional characterization of catechol degradation genes involved in carbazole degradation by Pseudomonas resinovorans strain CA10". Biosci. Biotechnol. Biochem. 66 (4): 897–901. doi:10.1271/bbb.66.897. PMID 12036072.
- ^ Nam; Chang, YS; Hong, HB; Lee, YE (2003). "A novel catabolic activity of Pseudomonas veronii in biotransformation of pentachlorophenol". Applied Microbiology and Biotechnology. 62 (2–3): 284–290. doi:10.1007/s00253-003-1255-1. PMID 12883877.
- ^ Onaca; Kieninger, M; Engesser, KH; Altenbuchner, J (May 2007). "Degradation of alkyl methyl ketones by Pseudomonas veronii". Journal of Bacteriology. 189 (10): 3759–3767. doi:10.1128/JB.01279-06. PMC 1913341. PMID 17351032.
- ^ Marqués S; Ramos JL (1993). "Transcriptional control of the Pseudomonas putida TOL plasmid catabolic pathways". Mol. Microbiol. 9 (5): 923–929. doi:10.1111/j.1365-2958.1993.tb01222.x. PMID 7934920.
- ^ Sepulveda-Torres; Rajendran, N; Dybas, MJ; Criddle, CS (1999). "Generation and initial characterization of Pseudomonas stutzeri KC mutants with impaired ability to degrade carbon tetrachloride". Arch Microbiol. 171 (6): 424–429. doi:10.1007/s002030050729. PMID 10369898.
- ^ Pereira, JN; Morgan, ME (Dec 1957). "Nutrition and physiology of Pseudomonas fragi". J Bacteriol. 74 (6): 710–3. PMC 289995. PMID 13502296.
{{cite journal}}: Unknown parameter|last-author-amp=ignored (|name-list-style=suggested) (help) - ^ Levine, M; Anderson, DQ (Apr 1932). "Two New Species of Bacteria Causing Mustiness in Eggs". J Bacteriol. 23 (4): 337–47. PMC 533329. PMID 16559557.
{{cite journal}}: Unknown parameter|last-author-amp=ignored (|name-list-style=suggested) (help) - ^ Gennari, M; Dragotto, F (Apr 1992). "A study of the incidence of different fluorescent Pseudomonas species and biovars in the microflora of fresh and spoiled meat and fish, raw milk, cheese, soil and water". J Appl Bacteriol. 72 (4): 281–8. doi:10.1111/j.1365-2672.1992.tb01836.x. PMID 1517169.
{{cite journal}}: Unknown parameter|last-author-amp=ignored (|name-list-style=suggested) (help) - ^ Van Landschoot, A.; Rossau, R.; De Ley, J. (1986). "Intra- and Intergeneric Similarities of the Ribosomal Ribonucleic Acid Cistrons of Acinetobacter". International Journal of Systematic Bacteriology. 36 (2): 150. doi:10.1099/00207713-36-2-150.
- ^ a b Hertveldt, K.; Lavigne, R.; Pleteneva, E.; Sernova, N.; Kurochkina, L.; Korchevskii, R.; Robben, J.; Mesyanzhinov, V.; Krylov, V. N.; Volckaert, G. (2005). "Genome Comparison of Pseudomonas aeruginosa Large Phages" (PDF). Journal of Molecular Biology. 354 (3): 536–545. doi:10.1016/j.jmb.2005.08.075. PMID 16256135.
- ^ Lavigne, R.; Noben, J. P.; Hertveldt, K.; Ceyssens, P. J.; Briers, Y.; Dumont, D.; Roucourt, B.; Krylov, V. N.; Mesyanzhinov, V. V.; Robben, J.; Volckaert, G. (2006). "The structural proteome of Pseudomonas aeruginosa bacteriophage KMV". Microbiology. 152 (2): 529–534. doi:10.1099/mic.0.28431-0. PMID 16436440.
{{cite journal}}: CS1 maint: unflagged free DOI (link) - ^ a b Ceyssens, P. -J.; Lavigne, R.; Mattheus, W.; Chibeu, A.; Hertveldt, K.; Mast, J.; Robben, J.; Volckaert, G. (2006). "Genomic Analysis of Pseudomonas aeruginosa Phages LKD16 and LKA1: Establishment of the KMV Subgroup within the T7 Supergroup". Journal of Bacteriology. 188 (19): 6924–6931. doi:10.1128/JB.00831-06. PMC 1595506. PMID 16980495.
- ^ Buchanan, R. E. (1955). "Taxonomy". Annual Review of Microbiology. 9: 1–20. doi:10.1146/annurev.mi.09.100155.000245. PMID 13259458.
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