Dopamine beta hydroxylase
Template:PBB Dopamine β-hydroxylase (DBH) is an enzyme that converts dopamine to norepinephrine.
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Norepinephrine. Note extra hydroxyl group.
DBH is a 290 kDa copper-containing oxygenase consisting of four identical subunits, and its activity requires ascorbate as a cofactor.[1] It is the only enzyme involved in the synthesis of small-molecule neurotransmitters that is membrane-bound, making norepinephrine and epinephrine the only transmitters synthesized inside vesicles. It is expressed in noradrenergic nerve terminals of the central and peripheral nervous systems, as well as in chromaffin cells of the adrenal medulla.
DBH is inhibited by disulfiram,[2] tropolone,[3] and, most selectively, by nepicastat.[4]
See also
References
- ^ Rush RA, Geffen LB (1980). "Dopamine beta-hydroxylase in health and disease". Crit Rev Clin Lab Sci. 12 (3): 241–77. doi:10.3109/10408368009108731. PMID 6998654.
- ^ Goldstein M, Anagnoste B, Lauber E, McKeregham MR (1964). "Inhibition of dopamine-beta-hydroxylase by Disulfiram". Life Sci. 3 (7): 763–7. doi:10.1016/0024-3205(64)90031-1. PMID 14203977.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Goldstein M, Lauber E, McKeregham MR (1964). "Inhibition of dopamine-beta-hydroxylase by tropolone and other chelating agents". Biochem Pharmacol. 13 (7): 1103–6. doi:10.1016/0006-2952(64)90109-1. PMID 14201135.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Stanley WC; et al. (1997). "Catecholamine modulatory effects of nepicastat (RS-25560-197), a novel, potent and selective inhibitor of dopamine-beta-hydroxylase". British Journal of Pharmacology. 121 (8): 1803–9. doi:10.1038/sj.bjp.0701315. PMC 1564872. PMID 9283721.
{{cite journal}}: Explicit use of et al. in:|author=(help); Unknown parameter|unused_data=ignored (help)
External links
- GeneReviews/NIH/NCBI/UW entry on Dopamine Beta-Hydroxylase Deficiency
- Dopamine+beta-Hydroxylase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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